Results 181 to 190 of about 13,626,059 (252)

Chemoenzymatic Synthesis of Asymmetric <i>N</i>-Glycans in Aqueous Solution via Sulfate and Phosphate Orthogonal Protection. [PDF]

J Am Chem Soc
Chen P, Li R, Zeng YF, Tseng TH, Krasnova L, Wong CH.   +5 more
europepmc   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Oxidative Release of Natural Glycans (ORNG): Preparation of Truncated N-glycans for Engineering Glycoproteins. [PDF]

Chemistry
Zhang Q, Azzam T, Lasanajak Y, Sundberg EJ, Song X.   +4 more
europepmc   +1 more source

Parkinson's Disease-Associated Remodeling of Synaptic <i>N</i>-Glycans in the Human Prefrontal Cortex. [PDF]

J Proteome Res
Adeniyi M, Fowowe M, Oluokun O, Sahioun S, Sandilya V, Daramola O, Bennett AI, Mechref Y.   +7 more
europepmc   +1 more source

Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims GNE myopathy (GNEM) is a rare, autosomal recessive disorder caused by mutations in the UDP‐N‐acetylglucosamine (GlcNAc) 2‐epimerase/N‐acetylmannosamine (ManNAc) kinase (GNE) gene, which encodes a required enzyme for sialic acid (SA) biosynthesis.
Kristina M. Sattler, Brian J. Paleo, Mackenzie N. Roth, Kara E. Bradley, Megan N. Winkler, Wakako Yoshioka, Ichizo Nishino, Christoph Lepper, Kelly E. Crowe   +8 more
wiley   +1 more source

A plant cell-based platform for the expression of complex proteins with fucose-reduced sialylated N-glycans. [PDF]

Plant Biotechnol J
Dianatkhah S, Kogelmann B, Melnik S, Eminger F, Kallolimath S, Sun L, Sumesgutner D, Traxlmayr MW, Sack M, Stoger E, Steinkellner H.   +10 more
europepmc   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

PNGaseF-Generated N-Glycans Adduct onto Peptides in the Gas Phase. [PDF]

J Am Soc Mass Spectrom
Rangel-Angarita V, Chongsaritsinsuk J, Mahoney KE, Kim LM, Chen RJ, Appah-Sampong AA, Tran IP, Steigmeyer AD, Hollenhorst MA, Malaker SA.   +9 more
europepmc   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Isomeric diversity of GlcNAc(Man₃GlcNAc₂) and GlcNAc₂(Man₃GlcNAc₂) N-glycans in multicellular eukaryotes. [PDF]

Sci Rep
Lin YT, Tsai MH, Yen CC, Chen JL, Liew CY, Huang YC, Sung HH, Chien CT, Ni CK.   +8 more
europepmc   +1 more source