Results 161 to 170 of about 3,818 (198)

A "terminal" case of glycan catabolism: Structural and enzymatic characterization of the sialidases of Clostridium perfringens. [PDF]

J Biol Chem
Medley BJ, Low KE, Irungu JDW, Kipchumba L, Daneshgar P, Liu L, Garber JM, Klassen L, Inglis GD, Boons GJ, Zandberg WF, Abbott DW, Boraston AB.   +12 more
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Dysregulated Sialylation in Cancer: From Immunosuppressive Microenvironment to Siglec-Targeted Therapeutics. [PDF]

Biomolecules
Zhang Y, Gao Z, Zhang Y, Ai S, Li W, Sun L.   +5 more
europepmc   +1 more source

2025: status of cardiac xenotransplantation including preclinical models. [PDF]

Front Transplant
Byrne GW, McGregor CGA.
europepmc   +1 more source

Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model. [PDF]

Transpl Int
Cooper DKC, Mou L, Cleveland JD, Simmons JH, Cleveland DC.   +4 more
europepmc   +1 more source

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Evidence suggesting that deletion of expression of N‐glycolylneuraminic acid (Neu5Gc) in the organ‐source pig is associated with increased antibody‐mediated rejection of kidney transplants in baboons

Xenotransplantation, 2021
Pigs deficient in three glycosyltransferase enzymes (triple‐knockout [TKO] pigs) and expressing “protective” human transgenes are likely sources of organs for transplantation into human recipients. Testing of human sera against red blood cells (RBCs) and
H. Iwase, Abhijit Jagdale, Takayuki Yamamoto, Mohamed H Bikhet, H. Nguyen, M. Ezzelarab, D. Ayares, Douglas J. Anderson, D. Eckhoff, J. Foote, Huma Fatima, H. Schuurman, H. Hara, D. Cooper   +13 more
semanticscholar   +3 more sources

The non-human glycan, N-glycolylneuraminic acid (Neu5Gc), is not expressed in all organs and skeletal muscles of nine animal species.

Food Chemistry, 2020
Red meat-derived sialic acid (Sia), N-glycolylneuraminic acid (Neu5Gc), promotes the risk of carcinoma and inflammation. Expression in skeletal muscle and organs across animal species remains unknown. We measured Neu5Gc in skeletal muscle and organ tissues from nine species using UHPLC and found that: (1) neu5Gc concentration in skeletal muscle was ...
M. Jahan, P. Thomson, P. Wynn, B. Wang
semanticscholar   +3 more sources

Effects of culture conditions on N‐glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells

Biotechnology and Bioengineering, 2010
AbstractCHO cells express glycoproteins containing both the N‐acetylneuraminic acid (Neu5Ac) and minor amounts of the N‐glycolylneuraminic acid (Neu5Gc) forms of sialic acid. As Neu5Gc is not expressed in humans and can be recognized as a foreign epitope, there is the potential for immunogenicity issues for glycoprotein therapeutics.
Michael C. Borys, N. G. Dalal, Nicholas R. Abu-Absi, Sarwat Khattak, Ying Jing, Zizhuo Xing, Z. Li   +6 more
semanticscholar   +3 more sources

PURIFICATION AND IDENTIFICATION OF N-GLYCOLYLNEURAMINIC ACID (Neu5Gc) FROM THE HOLOTHUROIDEA GUMI, CUCUMARIA ECHINATA

Preparative Biochemistry and Biotechnology, 2001
N-Glycolylneuraminic acid (Neu5Gc), precious sialic acid which could not be synthesized by a chemical method, occurrs in the body of holothuroidea, Gumi Cucumaria echinata. Gumi contains 85% of total sialic acid, as Neu5Gc, in the body. Neu5Gc was purified from dry powder of the body using Dowex 1-x8 (HCOO* form) anion exchange chromatography after ...
T. Sumi, I. Sallay, M. Asakawa, S. Park, Masaya Miyazaki, H. Ohba   +5 more
semanticscholar   +3 more sources

Abstract LB407: Enhancing sensitivity and specificity of the CA15-3 (MUC1) breast cancer assay by detection of N-glycolylneuraminic acid (Neu5Gc) using the lectin SubB2M

Cancer Research
The aim of this study was to test the hypothesis that the diagnostic performance (as defined by the classification accuracy, sensitivity and specificity) of CA15-3 to detect breast cancer is increased by detection of the cancer-associated Neu5Gc ...
S. Nikseresht, R. Khanabdali, Lucy Shewell, C. Day, A. M. McCart Reed, M. Jennings, Haarika Haarika, Sunil Sunil, Peter Simpson, R. Nabiee, M. Moore, L. Hinch, G. Rice   +12 more
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Neu5Gc (N-Glycolylneuraminic Acid)

, 2020
Among a group of SAs, NeuAc and NeuGc are two of the most common derivatives. SA biosynthesis begins at the cytosol and the synthesized SA is converted to activated nucleotide saccharide form in the nucleus. The activated SA is delivered to Golgi apparatus for ST reaction. STs add SA residues to the terminal sugars of the glycolipids, especially of the
C. Kim
semanticscholar   +2 more sources