Results 121 to 130 of about 151,535 (246)

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

PROTEIN N-GLYCOSYLATION OF GASTROPODS.

Current topics in biochemical research
Glycosylation plays an important role in several types of recognition processes associated with fertilisation and development, allergies, pathological events and cell death. Whereas the amino acid sequence of a protein is fixed by the DNA, the glycosylation abilities depend on enzymes and substrates currently present in the cell.During the last decades
Erika, Staudacher, Herwig, Stepan, Martin, Gutternigg   +2 more
openaire   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Expanding roles of N-glycosylation in the endoplasmic reticulum. [PDF]

Trends Cell Biol
Ma M, Rohatgi R.
europepmc   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie International Edition, EarlyView.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +1 more source

Iron-Catalyzed Stereospecific Heterocycle N-Glycosylation with Glycal Epoxides. [PDF]

Org Lett
Zhang XW, Zhang D, Jiang Z, Xu H.
europepmc   +1 more source

Mapping the Reactivity of the C═C Bond of Cyclic Enol Ether Derivatives of Sugars: Nucleophilicity Parameters of Glycals

Angewandte Chemie International Edition, EarlyView.
Endo or Exo? The first quantitative kinetic mapping of the nucleophilic reactivity of endo‐ and exo‐glycal compounds highlighted that endo‐glycals are typically 102 times less reactive than their corresponding parent cyclic enol ethers while exo‐glycals are 103 more nucleophilic. This experimental and computational structure–reactivity study highlights
Sophie Rodrigues, Saloua Chelli, Jenny Ha, Lucie Pedussaut, Sami Lakhdar, Raphaël Robiette, Stéphane P. Vincent, Guillaume Berionni   +7 more
wiley   +1 more source

Role of N-glycosylation as a determinant of ATG9A conformations and activity. [PDF]

Protein Sci
Utichi M, Lambrughi M, Marjault HB, Borg CB, Echeverría SE, Maeda K, Taylor NMI, Pedersen AG, Fadda E, Jäättelä M, Papaleo E.   +10 more
europepmc   +1 more source

Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome

Arthritis &Rheumatology, EarlyView.
Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca, Somanathapura K. NaveenKumar, Srilakshmi Yalavarthi, Kavya Sugur, Thalia G. Newman, Claire K. Hoy, Cyrus Sarosh, Jordan K. Schaefer, Ajay Tambralli, Jacqueline A. Madison, Yu Zuo, Fernanda A. Orsi, Michael Holinstat, Jason S. Knight   +13 more
wiley   +1 more source

Structural basis of regulated N-glycosylation at the secretory translocon. [PDF]

Nature
Yamsek M, Ma M, Jha R, Wan Y, Li Q, Zhong F, DeLong K, Ji Z, Rohatgi R, Keenan RJ.   +9 more
europepmc   +1 more source