Results 141 to 150 of about 13,659,719 (307)

An overview of protein N-glycosylation diversity in microalgae

Microalgae are unicellular photosynthetic eukaryotic organisms that arose from distinct endosymbiotic events yielding a wide phylogenetic diversity. In contrast, a single lineage of green algae charophytes gives rise to all land plants. A large number of
Rivet, Elodie, Lupette, Josselin, Patrice Lerouge, van Bockstaele-Fuentes, Julia, Muriel Bardor, Nesrine Gargouch, Gargouch, Nesrine, Lerouge, Patrice, Bardor, Muriel, Mati-Baouche, Narimane, Elodie Rivet, Julia van Bockstaele-Fuentes, Josselin Lupette, Narimane Mati-Baouche   +13 more
core   +1 more source

Site-specific N- and O-glycosylation analysis of atacicept

, 2019
The Fc-fusion protein atacicept is currently under clinical investigation for its biotherapeutic application in autoimmune diseases owing to its ability to bind the two cytokines B-Lymphocyte Stimulator (BLyS) and A PRoliferation-Inducing Ligand (APRIL).
Dominguez Vega, Elena, Hipgrave Ederveen, Agnes, L, Ederveen, A.L.H., Cutillo, F., Palmese, Angelo, Palmese, A., Cutillo, Francesca, Vega, E.D., Stavenhagen, Kathrin, Bierau, H., Bierau, Horst, Ederveen, Agnes L.Hipgrave, Palinsky, Wolf, Palinsky, W., Gahoual, R., Wuhrer, M., Wuhrer, Manfred, Gahoual, Rabah, Stavenhagen, K.   +18 more
core   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Proteomic Analysis of N- and O-linked Glycosylation based on Hydrophilic Interaction Chromatography

, 2013
Proteomic Analysis of N- and O-linked Glycosylation based on Hydrophilic Interaction ...
叶明亮, 王方军, 朱俊, 邹汉法, 程凯   +4 more
core  

Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation

Advanced Science, EarlyView.
Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Tao Lu, Mina Nikolić, Baihao Huang, Deep Punj, Herlinde De Keersmaecker, Thibaut Van Acker, Wenjia Xie, Florian Vanlauwe, Phillip Blondeel, Liesl De Graeve, Félix Sauvage, Ranhua Xiong, Chaobo Huang, Frank Vanhaecke, Kevin Braeckmans, Stefaan C. De Smedt   +15 more
wiley   +1 more source

A Reference Profile of N-Glycosylation for Human Kidney and the Identification of Cell-Cell Interactions between Parietal Epithelial Cells and Capillary Endothelial Cells by Single-Cell Glycosylation-Sequencing

Kidney & Blood Pressure Research
Background: N-glycosylation is one of the most common posttranslational modifications in humans, and these alterations are associated with kidney diseases. Methods: A novel technological approach, single-cell N-acetyllactosamine sequencing (scLacNAc-seq),
Mengyun Xiao, Qiang Yan, Shaodong Luan, Liusheng Lai, Zigan Xu, Yaoshuang Zou, Zhipeng Zeng, Haitao Li, Jing Qiu, Donge Tang, Lianghong Yin, Yong Dai   +11 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Development of a combined chemical and enzymatic approach for the mass spectrometric identification and quantification of aberrant N-glycosylation

, 2012
Direct mass spectrometric analysis of aberrant protein glycosylation is a challenge to the current analytical techniques. Except lectin affinity chromatography, no other glycosylation enrichment techniques are available for analysis of aberrant ...
Song, Chunxia, Wang, Fangjun, Wang, Hongyang, Zou, Hanfa, 邹汉法, Ye, Mingliang, Chen, Rui, Sun, Zhen, Tan, Yexiong   +8 more
core   +1 more source

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source