Results 161 to 170 of about 13,659,719 (307)
Angewandte Chemie, EarlyView.A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang +15 more
wiley +2 more sources
Annals of Gastroenterological Surgery, EarlyView.M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe +8 more
wiley +1 more source
Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics
Angewandte Chemie, EarlyView.Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee +4 more
wiley +2 more sources
Congenital disorders of glycosylation. Part I. Defects of protein N-glycosylation [PDF]
, 2013 Glycosylation is the most common chemical process of protein modification and occurs in every living cell. Disturbances of this process may be either congenital or acquired. Congenital disorders of glycosylation (CDG) are a rapidly growing disease family,
Chrostek, Lech +3 more
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Angewandte Chemie, EarlyView.The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang +6 more
wiley +2 more sources
Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.Protein‐binding aptamers remain poorly understood compared to their small‐molecule counterparts. Using green fluorescent protein (GFP) variants as a tractable model system, we show how subtle changes in protein surface composition and divalent metal ions reshape aptamer selection, specificity, and binding.
Stefen Stangherlin +8 more
wiley +2 more sources
A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant
Animal Models and Experimental Medicine, EarlyView.Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund +7 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley +1 more source