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Integrin α5β1 and Its N-Glycosylation
2014Integrins are transmembrane heterodimeric proteins sensing the cell microenvironment and modulating numerous signaling pathways. Changes in integrin function and expression between normal and tumor cells support involvement of specific integrins in tumor progression and aggressiveness.
Jianguo Gu +3 more
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N-glycosylation Engineering of Biopharmaceutical Expression Systems
Current Molecular Medicine, 2009N-glycosylation, the enzymatic coupling of oligosaccharides to specific asparagine residues of nascent polypeptide chains, is one of the most widespread post-translational modifications. Following transfer of an N-glycan precursor in the ER, this structure is further modified by a number of glycosidases and glyco-syltransferases in the ER and the Golgi
P P, Jacobs, N, Callewaert
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Scanning N-glycosylation mutagenesis of membrane proteins
Methods, 2007N-Glycosylation of eukaryotic membrane proteins is a co-translational event that occurs in the lumen of the endoplasmic reticulum (ER). This process is catalyzed by a membrane-associated oligosaccharyl transferase (OST) complex that transfers a preformed oligosaccharide (Glc(3)Man(9)GlcNAc(2)-) to an asparagine (Asn) side-chain acceptor located within ...
Joanne C, Cheung +1 more
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The N-glycosylation pattern of Caenorhabditis elegans
Carbohydrate Research, 2008Determining the exact nature of N-glycosylation in Caenorhabditis elegans, a nematode worm and genetic model organism, has proved to have been an unexpected challenge in recent years; a wide range of modifications of its N-linked oligosaccharides have been proposed on the basis of structural and genomic analysis. Particularly mass spectrometric studies
Katharina, Paschinger +3 more
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N-Glycosylation in progression of skin cancer
Medical Oncology, 2019Skin cancer can be classified as cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Due to the high level of morbidity and mortality, skin cancer has become a global public health issue worldwide while the pathogenesis of skin cancer is still unclear.
Ling Tang +7 more
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