Results 51 to 60 of about 182,092 (302)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein

Journal of Virology
Porcine epidemic diarrhea virus (PEDV), a highly pathogenic enteric coronavirus, has caused significant economic losses worldwide in recent years.
Huixin Zhu, Jinxiu Lou, Zhen Yang, Juan Bai, Ping Jiang, Xianwei Wang, Xing Liu   +6 more
doaj   +1 more source

Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen

mBio, 2019
In eukaryotes, glycosylation plays a role in proteome stability, protein quality control, and modulating protein function; however, similar studies in bacteria are lacking.
Sherif Abouelhadid, Simon J. North, Paul Hitchen, Prerna Vohra, Cosmin Chintoan-Uta, Mark Stevens, Anne Dell, Jon Cuccui, Brendan W. Wren   +8 more
doaj   +1 more source

Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi. [PDF]

, 2020
Anaerobic fungi (Neocallimastigomycota) are emerging non-model hosts for biotechnology due to their wealth of biomass-degrading enzymes, yet tools to engineer these fungi have not yet been established.
Albà, Arazoe, Atasoglu, Bach, Beckham, Bezanson, Birdsell, Boch, Bonugli-Santos, Brownlee, Calkins, Camacho, Camiolo, Carlson, Chan, Chen, Cheng, Cheng, Chokhawala, Coker, Deshpande, Diener, Dollhofer, Duarte, Durand, Duret, Fondon, Galtier, Gasiunas, Gentzsch, Gerngross, Glass, Glémin, Greene, Grigoriev, Haitjema, Haitjema, Hamilton, Hanafy, Hartfield, Henske, Hershberg, Hildebrand, Hull, Jiang, Karlin, Kiktev, Kleinstiver, Kleinstiver, Knauer, Knight, Kuyper, Leberer, Li, Liggenstoffer, Liu, Magee, Mertens, Meunier, Morrison, Murphy, Nicholson, Nieuwenhuis, Nørholm, Orpin, Oyola, O’Malley, Podolsky, Raymond, Reichenberger, Ropars, Sadhu, Sammond, Sekowska, Seppälä, Seppälä, Solieri, Solomon, Sonan, Staben, Steensels, Steensels, Sukumaran, Theodorou, UniProt: a worldwide hub of protein knowledge, Videvall, Wang, Wang, Wright, Wu, Ximenes, Youssef, Zetsche   +92 more
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Similarities and Differences in the Glycosylation Mechanisms in Prokaryotes and Eukaryotes

International Journal of Microbiology, 2010
Recent years have witnessed a rapid growth in the number and diversity of prokaryotic proteins shown to carry N- and/or O-glycans, with protein glycosylation now considered as fundamental to the biology of these organisms as it is in eukaryotic systems ...
Anne Dell, Alaa Galadari, Federico Sastre, Paul Hitchen   +3 more
doaj   +1 more source

Label-Free Quantitative Comparison of N-Glycoproteomics between Camel and Cow Milk [PDF]

Shipin Kexue
To understand the differential N-glycoprotein characteristics of camel versus cow milk, we employed label-free quantitative N-glycoproteomics to compare the N-glycoprotein composition and the number of N-glycosylation sites between the two milks and ...
LI Danlei, KONG Xiabing, YU Yue, HU Qian, ZHANG Jiukai, CHEN Ying
doaj   +1 more source

An N-glycoproteomic site-mapping analysis reveals glycoprotein alterations in esophageal squamous cell carcinoma

Journal of Translational Medicine, 2022
Background Aberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in eukaryotes.
Yingzhen Gao, Liuyi Shen, Tianyue Dong, Xin Yang, Heyang Cui, Yanlin Guo, Yanchun Ma, Pengzhou Kong, Xiaolong Cheng, Ling Zhang, Yongping Cui   +10 more
doaj   +1 more source

Hyper-replicative bovine leukemia virus by mutation of an envelope N-linked glycosylation site [PDF]

, 2014
peer reviewedReverse genetics can be used in the bovine leukemia virus (BLV) system to characterize mechanisms of viral persistence and pathogenesis. The question addressed here pertains to the role of glycans bound to the BLV envelope glycoprotein ...
A de Brogniez, AB Bouzar, J-R Jacques, N Gillet, O Pritsch, L Tomé, M Reichert, L Willems   +7 more
core   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source