Results 31 to 40 of about 155,076 (257)
Scientific Reports, 2021 N-linked glycosylation is a posttranslational modification affecting protein folding and function. The N-linked glycosylation pathway in algae is poorly characterized, and further knowledge is needed to understand the cell biology of algae and the ...
Joerg Behnke +2 more
doaj +1 more source
Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins
Scientific Reports, 2021 Here, we present for the first time, a site-specific N-glycosylation analysis of proteins from a Brazilian Zika virus (ZIKV) strain. The virus was propagated with high yield in an embryo-derived stem cell line (EB66, Valneva SE), and concentrated by g ...
Alexander Pralow +5 more
doaj +1 more source
N-glycosylation requirements in neuromuscular synaptogenesis [PDF]
Development, 2013 Neural development requires N-glycosylation regulation of intercellular signaling, but the requirements in synaptogenesis have not been well tested. All complex and hybrid N-glycosylation requires MGAT1 (UDP-GlcNAc:α-3-D-mannoside-β1,2-N-acetylglucosaminyl-transferase I) function, and Mgat1 nulls are the most compromised N-glycosylation condition that ...
William, Parkinson +3 more
openaire +2 more sources
Increased efficiency of Campylobacter jejuni N-oligosaccharyltransferase PglB by structure-guided engineering [PDF]
Open Biology, 2015 Conjugate vaccines belong to the most efficient preventive measures against life-threatening bacterial infections. Functional expression of N-oligosaccharyltransferase (N-OST) PglB of Campylobacter jejuni in Escherichia coli enables a simplified ...
Julian Ihssen +6 more
doaj +1 more source
Quantitative Analyses Reveal Novel Roles for
mBio, 2019 In eukaryotes, glycosylation plays a role in proteome stability, protein quality control, and modulating protein function; however, similar studies in bacteria are lacking.
Sherif Abouelhadid +8 more
doaj +1 more source
N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer
Cell Death and Disease, 2023 KIAA1324 is a transmembrane protein largely reported as a tumor suppressor and favorable prognosis marker in various cancers, including gastric cancer.
Rebecca Yun +9 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The role of N-glycosylation in cancer
Acta Pharmaceutica Sinica BDespite advances in understanding the development and progression of cancer in recent years, there remains a lack of comprehensive characterization of the cancer glycoproteome. Glycoproteins play an important role in medicine and are involved in various human disease conditions including cancer.
Yu Lin, David M. Lubman
openaire +3 more sources
N-Glycosylation in Regulation of the Nervous System [PDF]
, 2014 Protein N-glycosylation can influence the nervous system in a variety of ways by affecting functions of glycoproteins involved in nervous system development and physiology. The importance of N-glycans for different aspects of neural development has been well documented.
Hilary, Scott, Vladislav M, Panin
openaire +2 more sources
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source