Results 31 to 40 of about 155,572 (257)

Changes in protein N-glycosylation during the fruit development and ripening in melting-type peach

Food Materials Research, 2021
The posttranslational modification of proteins with complex carbohydrate moieties (glycosylation) regulates the process of fruit ripening. Exoglycosidases are enzymes that can trim this protein glycosylation and are therefore considered to be important ...
Ting Wang, Xi-Ran Jia, Li Liu, Josef Voglmeir   +3 more
doaj   +1 more source

Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

Beilstein Journal of Organic Chemistry, 2021
Sugar-modified nucleosides have gained considerable attention in the scientific community, either for use as molecular probes or as therapeutic agents. When the methylene group of the ribose ring is replaced with a sulfur atom at the 3’-position, these ...
Umesh P. Aher, Dhananjai Srivastava, Girij P. Singh, Jayashree B. S   +3 more
doaj   +1 more source

Phylogenetic analysis of promoter regions of human Dolichol kinase (DOLK) and orthologous genes using bioinformatics tools

Open Life Sciences, 2023
The Dolichol kinase (DOLK) gene encodes the polytopic DOLK protein associated with the endoplasmic reticulum (ER) N-glycosylation pathway catalyzing the final step in the biosynthesis of dolichol phosphate.
Farooqi Nadia, Rahman Ataur, Ali Yasir, Ali Kishwar, Khan Muhammad Ezaz Hasan, Jones David Aaron, Abdelkarim Mouadh, Ullah Farman, Jalil Fazal   +8 more
doaj   +1 more source

N-glycosylation requirements in neuromuscular synaptogenesis [PDF]

Development, 2013
Neural development requires N-glycosylation regulation of intercellular signaling, but the requirements in synaptogenesis have not been well tested. All complex and hybrid N-glycosylation requires MGAT1 (UDP-GlcNAc:α-3-D-mannoside-β1,2-N-acetylglucosaminyl-transferase I) function, and Mgat1 nulls are the most compromised N-glycosylation condition that ...
William, Parkinson, Mary Lynn, Dear, Emma, Rushton, Kendal, Broadie   +3 more
openaire   +2 more sources

N-linked glycosylation enzymes in the diatom Thalassiosira oceanica exhibit a diel cycle in transcript abundance and favor for NXT-type sites

Scientific Reports, 2021
N-linked glycosylation is a posttranslational modification affecting protein folding and function. The N-linked glycosylation pathway in algae is poorly characterized, and further knowledge is needed to understand the cell biology of algae and the ...
Joerg Behnke, Alejandro M. Cohen, Julie LaRoche   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein

Journal of Virology
Porcine epidemic diarrhea virus (PEDV), a highly pathogenic enteric coronavirus, has caused significant economic losses worldwide in recent years.
Huixin Zhu, Jinxiu Lou, Zhen Yang, Juan Bai, Ping Jiang, Xianwei Wang, Xing Liu   +6 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen

mBio, 2019
In eukaryotes, glycosylation plays a role in proteome stability, protein quality control, and modulating protein function; however, similar studies in bacteria are lacking.
Sherif Abouelhadid, Simon J. North, Paul Hitchen, Prerna Vohra, Cosmin Chintoan-Uta, Mark Stevens, Anne Dell, Jon Cuccui, Brendan W. Wren   +8 more
doaj   +1 more source

The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization

Viruses, 2020
Tetherin is an interferon-inducible type II transmembrane glycoprotein which inhibits the release of viruses, including retroviruses, through a “physical tethering” model.
Bowen Bai, Xue-Feng Wang, Mengmeng Zhang, Lei Na, Xiangmin Zhang, Haili Zhang, Zhibiao Yang, Xiaojun Wang   +7 more
doaj   +1 more source