Results 31 to 40 of about 13,650,971 (300)

Approaching the secrets of N-glycosylation in Aspergillus fumigatus [PDF]

, 2010
The mannosyltransferase Och1 is the key enzyme for synthesis of elaborated protein N-glycans in yeast. In filamentous fungi genes implicated in outer chain formation are present, but their function is unclear.
Engel Jakob, Echtenacher, Bernd, Bernd Echtenacher, Ilse Jacobsen, Kotz, Andrea, Routier Françoise H., Wagener, Johannes, Routier, Françoise H., Engel, Jakob, Kotz Andrea, Ebel Frank, Frank Ebel, Jacobsen Ilse, Françoise H Routier, Wagener Johannes, Heesemann, Jürgen, Johannes Wagener, Nielsen, Kirsten, Echtenacher Bernd, Jakob Engel, Ebel, Frank, Jürgen Heesemann, Heesemann Jürgen, Andrea Kotz, Françoise H. Routier, Jacobsen, Ilse   +25 more
core   +2 more sources

LINC00173 promotes Wilms’ tumor progression through MGAT1-mediated MUC3A N-glycosylation

, 2022
Recent studies have unveiled that LINC00173 promotes small cell lung cancer progression. However, LINC00173 has not been studied in Wilms’ tumor (WT).
Qingliang Zhu (12484975), Deming Zhan (12484978), Haoliang Xue (6033464), Yongguo Yang (11021152), Yankun Chong (12484981), Peng Zhu (277243)   +5 more
core   +1 more source

The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris

Microbial Cell Factories, 2022
Background N-glycosylation is one of the most important post-translational modifications. Many studies have shown that N-glycosylation has a significant effect on the secretion level of heterologous glycoproteins in yeast cells.
Nan Wang, Caifeng Yang, Huakang Peng, Wenfang Guo, Mengqi Wang, Gangqiang Li, Dehu Liu   +6 more
doaj   +1 more source

High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect

eLife, 2018
Proper brain development relies highly on protein N-glycosylation to sustain neuronal migration, axon guidance and synaptic physiology. Impairing the N-glycosylation pathway at early steps produces broad neurological symptoms identified in congenital ...
Daniel Medina-Cano, Ekin Ucuncu, Lam Son Nguyen, Michael Nicouleau, Joanna Lipecka, Jean-Charles Bizot, Christian Thiel, François Foulquier, Nathalie Lefort, Catherine Faivre-Sarrailh, Laurence Colleaux, Ida Chiara Guerrera, Vincent Cantagrel   +12 more
doaj   +1 more source

Quantitative proteomics analysis reveals important roles of N-glycosylation on ER quality control system for development and pathogenesis in Magnaporthe oryzae.

PLoS Pathogens, 2020
Genetic studies have shown essential functions of N-glycosylation during infection of the plant pathogenic fungi, however, systematic roles of N-glycosylation in fungi is still largely unknown.
Xiao-Lin Chen, Caiyun Liu, Bozeng Tang, Zhiyong Ren, Guo-Liang Wang, Wende Liu   +5 more
doaj   +1 more source

Impact of Yeast Glycosylation Pathway on Cell Integrity and Morphology, Glycosylation, Stefana Petrescu (Ed.), ISBN: 978-953-51-0771-2, InTech, Available from: http://www.intechopen.com/books/glycosylation/impact-of-yeast-glycosylation-pathway-on-cell-integrity-and-morphology [PDF]

, 2012
Protein glycosylation is a multi step reaction, well conserved in the eukaryotic cells. In N-glycosylation reactions dolichyl phosphate (DolP) serves as a lipid acceptor of sugar residues forming DolPPGlcNAc2Man9Glc3.
Palamarczyk, Grazyna, Juchimiuk, Mateusz, Pasikowska, Monika, Janik, Anna, Orłowski, Jacek, Kruszewska, Joanna S.   +5 more
core   +1 more source

The role of N-glycosylation in folding, trafficking, and functionality of lysosomal protein CLN5. [PDF]

PLoS ONE, 2013
CLN5 is a soluble lysosomal protein with unknown function. Mutations in CLN5 lead to neuronal ceroid lipofuscinosis, a group of inherited neurodegenerative disorders that mainly affect children. CLN5 has eight potential N-glycosylation sites based on the
Akshay Moharir, Sun H Peck, Theodore Budden, Stella Y Lee   +3 more
doaj   +1 more source

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]

, 2009
We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Huet, Guillemette, Stechly, Laurence, André, Sabine, Seuningen, Isabelle Van, van Seuningen, Isabelle, Gabius, Hans-Joachim, Morelle, Willy, Michalski, Jean-Claude, Porchet, Nicole   +8 more
core   +1 more source

Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins

Scientific Reports, 2021
Here, we present for the first time, a site-specific N-glycosylation analysis of proteins from a Brazilian Zika virus (ZIKV) strain. The virus was propagated with high yield in an embryo-derived stem cell line (EB66, Valneva SE), and concentrated by g ...
Alexander Pralow, Alexander Nikolay, Arnaud Leon, Yvonne Genzel, Erdmann Rapp, Udo Reichl   +5 more
doaj   +1 more source

Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues

Frontiers in Immunology, 2021
Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain.
Xingang Li, Xingang Li, Hao Wang, Hao Wang, Yahong Zhu, Weijie Cao, Weijie Cao, Manshu Song, Manshu Song, Youxin Wang, Haifeng Hou, Minglin Lang, Xiuhua Guo, Xuerui Tan, Jingdong J. Han, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Wei Wang   +19 more
doaj   +1 more source