Results 31 to 40 of about 182,092 (302)

Research advances of protein N-glycosylation’s biological functions and analytical methods and its role in kidney disease

Linchuang shenzangbing zazhi, 2021
As one of the most important post-translational modifications, glycosylation plays a significant role in the functions of proteins.N-glycosylation exerts critical effects in different biological processes among various forms of glycosylation, whereas ...
任伟夫, 边琪
doaj  

N-glycosylation in the thermoacidophilic archaeon Sulfolobus acidocaldarius involves a short dolichol pyrophosphate carrier [PDF]

, 2016
N-glycosylation is a post-translational modification that occurs across evolution. In the thermoacidophilic archaea Sulfolobus acidocaldarius, glycoproteins are modified by an N-linked tribranched hexasaccharide reminiscent of the N-glycans assembled in ...
Abu-Qarn, Aebi, Albers, Bligh, Brock, Burda, Calo, Chang, Cohen-Rosenzweig, Eichler, Guan, Guan, Guan, Gulik, Hartley, Hartmann, Jarrell, Jones, Kaminski, Kandiba, Kelleher, Kuntz, Larkin, Lechner, Lehrman, Mescher, Meyer, Meyer, Meyer, Nothaft, Palmieri, Peyfoon, Shams-Eldin, Swiezewska, Szymanski, Taguchi, Wagner, Weerapana, Zahringer   +38 more
core   +3 more sources

The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris

Microbial Cell Factories, 2022
Background N-glycosylation is one of the most important post-translational modifications. Many studies have shown that N-glycosylation has a significant effect on the secretion level of heterologous glycoproteins in yeast cells.
Nan Wang, Caifeng Yang, Huakang Peng, Wenfang Guo, Mengqi Wang, Gangqiang Li, Dehu Liu   +6 more
doaj   +1 more source

Attenuation of N-glycosylation causes polarity and adhesion defects in the C. elegans embryo [PDF]

, 2017
The C. elegans early embryo is highly polarized, requiring sequestration of cytoplasmic polarity factors at the plasma membrane. This compartmentalization aids asymmetric distribution of lipids and proteins, which is partially responsible for the fates ...
Spang, Anne, Stevens, Julia
core   +1 more source

Analysis of N-Glycosylation Sites in HIV glycoprotein 160 [PDF]

, 2011
HIV infection is a condition caused by the human immunodeficiency virus. The condition gradually destroys the immune system, which makes it harder for the body to fight infections. HIV presents a complex knot for scientists to unravel.
Rajendra Mandage
core   +2 more sources

High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect

eLife, 2018
Proper brain development relies highly on protein N-glycosylation to sustain neuronal migration, axon guidance and synaptic physiology. Impairing the N-glycosylation pathway at early steps produces broad neurological symptoms identified in congenital ...
Daniel Medina-Cano, Ekin Ucuncu, Lam Son Nguyen, Michael Nicouleau, Joanna Lipecka, Jean-Charles Bizot, Christian Thiel, François Foulquier, Nathalie Lefort, Catherine Faivre-Sarrailh, Laurence Colleaux, Ida Chiara Guerrera, Vincent Cantagrel   +12 more
doaj   +1 more source

Quantitative proteomics analysis reveals important roles of N-glycosylation on ER quality control system for development and pathogenesis in Magnaporthe oryzae.

PLoS Pathogens, 2020
Genetic studies have shown essential functions of N-glycosylation during infection of the plant pathogenic fungi, however, systematic roles of N-glycosylation in fungi is still largely unknown.
Xiao-Lin Chen, Caiyun Liu, Bozeng Tang, Zhiyong Ren, Guo-Liang Wang, Wende Liu   +5 more
doaj   +1 more source

The role of N-glycosylation in folding, trafficking, and functionality of lysosomal protein CLN5. [PDF]

PLoS ONE, 2013
CLN5 is a soluble lysosomal protein with unknown function. Mutations in CLN5 lead to neuronal ceroid lipofuscinosis, a group of inherited neurodegenerative disorders that mainly affect children. CLN5 has eight potential N-glycosylation sites based on the
Akshay Moharir, Sun H Peck, Theodore Budden, Stella Y Lee   +3 more
doaj   +1 more source

Structure analysis of biologically important prokaryotic glycopolymers [PDF]

, 2013
Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria, Ventura, Valeria Victoria   +1 more
core   +1 more source

Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins

Scientific Reports, 2021
Here, we present for the first time, a site-specific N-glycosylation analysis of proteins from a Brazilian Zika virus (ZIKV) strain. The virus was propagated with high yield in an embryo-derived stem cell line (EB66, Valneva SE), and concentrated by g ...
Alexander Pralow, Alexander Nikolay, Arnaud Leon, Yvonne Genzel, Erdmann Rapp, Udo Reichl   +5 more
doaj   +1 more source