Results 21 to 30 of about 155,076 (257)

Variation of the serum N‐glycosylation during the pregnancy of a MPI‐CDG patient

JIMD Reports, 2021
For the first time the glycosylation of a patient with a MPI‐CDG during pregnancy is monitored. MPI‐CDG, is characterised by a deficiency in mannose‐6‐phosphate isomerase (MPI) leading to a reduced pool of glycosylation precursors, impairing the ...
Elodie Lebredonchel, Sandrine Duvet, Claire Douillard, François Foulquier, André Klein   +4 more
doaj   +1 more source

Differential Analysis of N-glycopeptide Abundance and N-glycosylation Site Occupancy for Studying Protein N-glycosylation Dysregulation in Human Disease

Bio-Protocol, 2021
Protein N-glycosylation plays a vital role in diverse cellular processes, and dysregulated N-glycosylation is implicated in a variety of human diseases including neurodegenerative disorders and cancer.
Qi Zhang, Cheng Ma, Lian Li, Lih-Shen Chin   +3 more
doaj   +1 more source

Research advances of protein N-glycosylation’s biological functions and analytical methods and its role in kidney disease

Linchuang shenzangbing zazhi, 2021
As one of the most important post-translational modifications, glycosylation plays a significant role in the functions of proteins.N-glycosylation exerts critical effects in different biological processes among various forms of glycosylation, whereas ...
任伟夫, 边琪
doaj  

The role of N-glycosylation in folding, trafficking, and functionality of lysosomal protein CLN5. [PDF]

PLoS ONE, 2013
CLN5 is a soluble lysosomal protein with unknown function. Mutations in CLN5 lead to neuronal ceroid lipofuscinosis, a group of inherited neurodegenerative disorders that mainly affect children. CLN5 has eight potential N-glycosylation sites based on the
Akshay Moharir, Sun H Peck, Theodore Budden, Stella Y Lee   +3 more
doaj   +1 more source

Role of N-Glycosylation in Human Angiotensinogen [PDF]

Journal of Biological Chemistry, 1998
Human angiotensinogen, the specific substrate of renin, is a heterogeneous glycoprotein constitutively secreted by the liver. Different glycosylation levels may be responsible for its heterogeneity. It contains four putative asparagine-linked glycosylation sites (Asn-X-Ser/Thr). Systematic site-directed mutagenesis (Asn replaced with Gln) of these four
A P, Gimenez-Roqueplo, J, Célérier, G, Lucarelli, P, Corvol, X, Jeunemaitre   +4 more
openaire   +2 more sources

High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect

eLife, 2018
Proper brain development relies highly on protein N-glycosylation to sustain neuronal migration, axon guidance and synaptic physiology. Impairing the N-glycosylation pathway at early steps produces broad neurological symptoms identified in congenital ...
Daniel Medina-Cano, Ekin Ucuncu, Lam Son Nguyen, Michael Nicouleau, Joanna Lipecka, Jean-Charles Bizot, Christian Thiel, François Foulquier, Nathalie Lefort, Catherine Faivre-Sarrailh, Laurence Colleaux, Ida Chiara Guerrera, Vincent Cantagrel   +12 more
doaj   +1 more source

Quantitative proteomics analysis reveals important roles of N-glycosylation on ER quality control system for development and pathogenesis in Magnaporthe oryzae.

PLoS Pathogens, 2020
Genetic studies have shown essential functions of N-glycosylation during infection of the plant pathogenic fungi, however, systematic roles of N-glycosylation in fungi is still largely unknown.
Xiao-Lin Chen, Caiyun Liu, Bozeng Tang, Zhiyong Ren, Guo-Liang Wang, Wende Liu   +5 more
doaj   +1 more source

The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris

Microbial Cell Factories, 2022
Background N-glycosylation is one of the most important post-translational modifications. Many studies have shown that N-glycosylation has a significant effect on the secretion level of heterologous glycoproteins in yeast cells.
Nan Wang, Caifeng Yang, Huakang Peng, Wenfang Guo, Mengqi Wang, Gangqiang Li, Dehu Liu   +6 more
doaj   +1 more source

Human plasma protein N-glycosylation [PDF]

Glycoconjugate Journal, 2015
Glycosylation is the most abundant and complex protein modification, and can have a profound structural and functional effect on the conjugate. The oligosaccharide fraction is recognized to be involved in multiple biological processes, and to affect proteins physical properties, and has consequentially been labeled a critical quality attribute of ...
Clerc, F., Reiding, K.R., Jansen, B.C., Kammeijer, G.S.M., Bondt, A., Wuhrer, M.   +5 more
openaire   +3 more sources

Changes in protein N-glycosylation during the fruit development and ripening in melting-type peach

Food Materials Research, 2021
The posttranslational modification of proteins with complex carbohydrate moieties (glycosylation) regulates the process of fruit ripening. Exoglycosidases are enzymes that can trim this protein glycosylation and are therefore considered to be important ...
Ting Wang, Xi-Ran Jia, Li Liu, Josef Voglmeir   +3 more
doaj   +1 more source