Results 251 to 260 of about 111,646 (306)
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Deramciclane inhibits N-methyl-D-aspartate receptor function
Brain Research Bulletin, 2000Effects of the novel anxiolytic drug deramciclane on excitatory amino acid release and transmembrane Ca(2+) ion flux processes were compared in rat cerebrocortical homogenates containing resealed plasmalemma fragments and nerve endings. Deramciclane (10 microM) significantly inhibited [(3)H]D-aspartate release and transmembrane Ca(2+) flux to N-methyl ...
I, Kovács +3 more
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Molecular Pharmacology, 1989
Five structural features important for activation of the glycine recognition site on N-methyl-D-aspartate (NMDA) receptors were identified by structure-activity studies of more than 60 glycine analogues in voltage-clamped Xenopus oocytes injected with ...
C. McBain +3 more
semanticscholar +1 more source
Five structural features important for activation of the glycine recognition site on N-methyl-D-aspartate (NMDA) receptors were identified by structure-activity studies of more than 60 glycine analogues in voltage-clamped Xenopus oocytes injected with ...
C. McBain +3 more
semanticscholar +1 more source
The promise of N-methyl-d-aspartate receptor antagonists in fibromyalgia
Rheumatic Disease Clinics of North America, 2002There is strong evidence that intravenous administration of ketamine following a standardized protocol could be used as a diagnostic test for a central sensitization in the central nervous system in patients with FM. The combination of a weak opioid and an NMDA-receptor antagonist with few side effects is presently a promise for treatment of pain in a ...
Karl G, Henriksson, Jan, Sörensen
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Proteolysis of the N-Methyl-d-Aspartate Receptor by Calpain in Situ
The Journal of Pharmacology and Experimental Therapeutics, 2002N-Methyl-D-aspartate (NMDA) receptors are calcium-permeable glutamate receptors that play putative roles in learning, memory, and excitotoxicity. NMDA receptor-mediated calcium entry can activate the calcium-dependent protease calpain, leading to substrate degradation. The major NMDA receptor 2 (NR2) subunits of the receptor are in vitro substrates for
Rodney P, Guttmann +5 more
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Modeling of N-Methyl-D-Aspartate Receptors
2019Several reduced kinetic models for N-methyl-D-aspartate receptors were derived in order to suit different experimental protocols. Their simultaneous application allows for a step-wise estimation of parameters of a conventional model that is otherwise overparameterized with respect to the existing data.
Denis Shchepakin +2 more
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Opiate physical dependence and N-methyl-d-aspartate receptors
European Journal of Pharmacology, 2004The present review focused the involvement of N-methyl-D-aspartate (NMDA) receptors in morphine physical dependence. The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are ...
Yukihiro, Noda, Toshitaka, Nabeshima
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Excitotoxicity and N‐methyl‐D‐Aspartate receptors
Drug Development Research, 1989AbstractA great deal of new information has been generated over the past decade in the excitatory amino acid (EAA) field. Not only have endogenous EAA such as glutamate and aspartate become recognized as the leading neurotransmitter candidates at the majority of excitatory synapses in the mammalian central nervous system, but it is becoming ...
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Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.
Science, 1984R. Simon +3 more
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Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors.
Journal of Neurophysiology, 1998S. Vicini +7 more
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Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors.
Brain Research, 1984E. W. Harris, A. Ganong, C. Cotman
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