Results 231 to 240 of about 111,646 (306)

N-Methyl-D-Aspartate Receptors in the Retina

Molecular Neurobiology, 2006
The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible for mediating the transfer of ...
Yin, Shen, Xiao-Ling, Liu, Xiong-Li, Yang   +2 more
openaire   +2 more sources

The N-Methyl-D-Aspartate Receptor Complex

Journal of Receptor Research, 1988
The effects of agonists of the N-methyl-D-aspartate (NMDA) receptor can be blocked by dissociative anesthetics such as phencyclidine (PCP) in a non-competitive manner. This finding together with the fact that ligand binding to the PCP receptor is dependent on the presence of L-glutamate has led to the suggestion that there may exist an NMDA/PCP ...
M, Williams, P A, Loo, D E, Murphy, A F, Braunwalder, M F, Jarvis, M A, Sills   +5 more
openaire   +2 more sources

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

Pharmacological Reviews, 1998
Since the finding by [Johnson and Ascher (1987)][1] demonstrating that glycine enhances electrophysiological responses mediated by N-methyl-d-aspartate (NMDA)b-sensitive glutamatergic receptors, considerable interest has been devoted to this topic (for ...
W. Danysz, C. Parsons
semanticscholar   +1 more source

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

Journal of Pharmacology and Experimental Therapeutics, 1997
The interaction of Ro 25-6981 with N-methyl-D-aspartate (NMDA) receptors was characterized by a variety of different tests in vitro. Ro 25-6981 inhibited 3H-MK-801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0.003 microM ...
G. Fischer, V. Mutel, G. Trube, P. Malherbe, J. Kew, E. Mohacsi, M. Heitz, J. Kemp   +7 more
semanticscholar   +1 more source

Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells.

Molecular Pharmacology, 1995
The pharmacological properties of two recombinant human N-methyl-D-aspartate (NMDA) receptor subtypes, comprising either NR1a/NR2A or NR1a/NR2B subunits permanently transfected into mouse L(tk-) cells, have been compared using whole-cell voltage-clamp ...
T. Priestley, P. Laughton, J. Myers, B. L. Bourdelles, J. Kerby, P. Whiting   +5 more
semanticscholar   +1 more source

N-methyl-D-aspartate receptors and Alzheimer's disease

Neurobiology of Aging, 1989
The results of several studies now suggest that the density of N-methyl-D-aspartate (NMDA) receptors is maintained in many Alzheimer's disease (AD) cases, although loss of these receptors can occur in specific regions as a consequence of severe neuronal loss.
C W, Cotman, J W, Geddes, R J, Bridges, D T, Monaghan   +3 more
openaire   +2 more sources

Assembly of N-methyl-d-aspartate (NMDA) receptors

Biochemical Society Transactions, 2003
The N-methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different subunits to both the function and pharmacology of the NMDAR, the precise subunit stoichiometry of the receptor and the regions of the subunits governing ...
R A J, McIlhinney, E, Philipps, B, Le Bourdelles, S, Grimwood, K, Wafford, S, Sandhu, P, Whiting   +6 more
openaire   +2 more sources

The pharmacology of tacrine at N -methyl- d -aspartate receptors

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017
The mechanism of tacrine as a precognitive drug has been considered to be complex and not fully understood. It has been reported to involve a wide spectrum of targets involving cholinergic, gabaergic, nitrinergic and glutamatergic pathways. Here, we review the effect of tacrine and its derivatives on the NMDA receptors (NMDAR) with a focus on the ...
Martin Horak, Kristina Holubova, Eugenie Nepovimova, Jan Krusek, Martina Kaniakova, Jan Korabecny, Ladislav Vyklicky, Kamil Kuca, Ales Stuchlik, Jan Ricny, Karel Vales, Ondrej Soukup   +11 more
openaire   +2 more sources

Anti-N-Methyl-d-Aspartate Receptor Encephalitis

The American Journal of the Medical Sciences, 2013
A case of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis with an atypical finding of transient increased intracranial pressure is reported. Anti-NMDAR encephalitis is an underrecognized, novel and treatable form of encephalitis being increasingly identified as an explanation of encephalitis in young adults.
Sian Y, Lim, Ragesh, Panikkath, Charoen, Mankongpaisarnrung, Ebtesam, Islam, Zachary, Mulkey, Kenneth, Nugent   +5 more
openaire   +2 more sources

Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.

Journal of Pharmacology and Experimental Therapeutics, 1992
The chiral forms of ketamine were applied as probes for N-methyl-D-aspartate receptor-mediated neurotransmission in humans. Both enantiomers, in clinically relevant concentrations, displaced [3H]dizocilpine (MK 801) from specific binding sites ...
I. Øye, O. Paulsen, A. Maurset
semanticscholar   +1 more source