Results 21 to 30 of about 111,646 (306)

Enhancement of spinal dorsal horn neuron N-methyl-D-aspartate receptor phosphorylation as the mechanism of remifentanil-induced hyperalgesia: Roles of protein kinase C and calcium/calmodulin-dependent protein kinase II

Molecular Pain, 2017
Background Modulation of N-methyl-D-aspartate receptor subunits NR1 and NR2 through phosphorylation mediates opioid-induced hyperalgesia, and activations of protein kinase C and extracellular signal-regulated kinase 1/2 potentiate while activation of ...
Sisi Li, Jie Zeng, Xiaoxiao Wan, Ying Yao, Yujia Wu, Nan Zhao, Cong Yu, Zhengyuan Xia   +7 more
doaj   +1 more source

Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors.

Neuron, 1998
Ca2+ influx through N-methyl-D-aspartate (NMDA) receptors activates signal transduction pathways critical for many forms of synaptic plasticity in the brain.
Su Zhang, M. Ehlers, Jeffery P Bernhardt, Ching Tien Su, R. Huganir   +4 more
semanticscholar   +1 more source

Neuron-derived D-Serine Release Provides a Novel Means to Activate N-Methyl-D-aspartate Receptors*

Journal of Biological Chemistry, 2006
d-Serine is a coagonist of N-methyl-d-aspartate (NMDA) receptors that occurs at high levels in the brain. Biosynthesis of d-serine is carried out by serine racemase, which converts l-to d-serine.
Elena Kartvelishvily, M. Shleper, L. Balan, E. Dumin, Herman Wolosker   +4 more
semanticscholar   +1 more source

Anti-N-Methyl-d-Aspartate Receptor Encephalitis

Pediatrics & Neonatology, 2011
Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a treatment-responsive encephalitis associated with anti-NMDA receptor antibodies, which bind to the NR1/NR2 heteromers of the NMDA receptors. It is a highly characteristic syndrome evolving in five stages: the prodromal phase (viral infection-like symptoms), psychotic phase, unresponsive phase,
Te-Yu Hung, Ning-Hui Foo, Ming-Chi Lai
openaire   +3 more sources

Polyglutamine-expanded Huntingtin Promotes Sensitization of N-Methyl-d-aspartate Receptors via Post-synaptic Density 95*

Journal of Biological Chemistry, 2001
Increased glutamate-mediated excitotoxicity seems to play an important role in the pathogenesis of Huntington's disease (Tabrizi, S. J., Cleeter, M. W., Xuereb, J., Taaman, J. W., Cooper, J. M., and Schapira, A. H. (1999)Ann. Neurol. 45, 25–32). However,
Y. Sun, Anneli Savanenin, P. Reddy, Y. Liu   +3 more
semanticscholar   +1 more source

Development and characterization of functional antibodies targeting NMDA receptors

Nature Communications, 2022
Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders.
Nami Tajima, Noriko Simorowski, Remy A. Yovanno, Michael C. Regan, Kevin Michalski, Ricardo Gómez, Albert Y. Lau, Hiro Furukawa   +7 more
doaj   +1 more source

Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke

Brain, Behavior, & Immunity - Health, 2023
Background: Anti-NMDA-receptor GluN1 antibodies (NMDAR1-abs) are present in an autoimmune encephalitis with severe neuropsychiatric symptoms. We aimed to estimate the impact of serum NMDAR1-abs on depressive symptoms years after first-ever ischemic ...
Pia S. Sperber, Pimrapat Gebert, Leonie H.A. Broersen, Anna Kufner, Shufan Huo, Sophie K. Piper, Bianca Teegen, Peter U. Heuschmann, Harald Prüss, Matthias Endres, Thomas G. Liman, Bob Siegerink   +11 more
doaj   +1 more source

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors

Journal of Pharmacological Sciences, 2022
N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine).
Tomohiko Irie, Yuta Yanase, Yosuke Demizu, Makoto Usami, Ruri Kikura-Hanajiri   +4 more
doaj   +1 more source

Cyclic AMP-dependent Protein Kinase and Protein Kinase C Phosphorylate N-Methyl-d-aspartate Receptors at Different Sites*

Journal of Biological Chemistry, 1997
Ca2+ influx throughN-methyl-d-aspartate (NMDA)-type glutamate receptors plays a pivotal role in synaptic plasticity during brain development as well as in mature brain.
Soren Leonard, J. Hell
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source