Results 21 to 30 of about 10,564,162 (159)

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N\AThis paper explores the integration of Unmanned Aerial Systems (UAS) for 3D terrain mapping and autonomous navigation, emphasizing the fusion of advanced technologies such as multi-camera setups and reinforcement learning (RL).
Baston, George
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Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, Volume 10, Issue S1, Page S53-S86, August 2025.
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou, Hana Kubova, Stéphane Auvin, Massimo Mantegazza, Melissa Barker‐Haliski, Aristea S. Galanopoulou, Christopher A. Reid, Bridgette D. Semple   +7 more
wiley   +1 more source

Seizure Activity and Hypoxia Differentially Regulate Endogenous Neurotrophic Activin A and Neuroglobin Expression in the Immature Mouse Brain

International Journal of Developmental Neuroscience, Volume 85, Issue 5, August 2025.
We investigated the regulatory effects of seizure‐induced excitotoxicity and acute hypoxia on the cytoprotective activin A and Ngb systems in the developing mouse brain. Our results demonstrate the differential regulation of Ngb and activin A as a function of time and type of injury and suggest their potential role as biomarkers of excitotoxic and ...
Clara Becker, Susan Jung, Regina Trollmann   +2 more
wiley   +1 more source

Resolución CSPyGE N° 28/2022. Derogar las Resoluciones CSPyGE N° 14/2022 y N° 15/2020. Convalidar la Resolución Rectoral N° 825/2022.

, 2022
Fil: Consejo Superior de Programación y Gestión Estratégica (P). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución CSPyGE N° 28/2022. Derogar las Resoluciones CSPyGE N° 14/2022 y N° 15/2020.
Consejo Superior de Programación y Gestión Estratégica (P)
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Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Downstream Signaling of Muscarinic M4 Receptors Is Regulated by Receptor Density and Cellular Environment

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeutic applications, this study investigates M4 receptor ...
Madeleine Merz, Charlotte Playle, Monika Palchaudhuri, Oliver Hucke, Ulrike Gross, Daniel Ursu   +5 more
wiley   +1 more source

An extended substrate spectrum of the proton organic cation antiporter and relation to other cation transporters

Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 6, Page 720-742, December 2024.
Abstract Most central nervous system (CNS) active drugs are organic cations, which need carrier proteins for efficient transfer through the blood–brain barrier (BBB). A genetically still unidentified proton organic cation (H+/OC) antiporter is found in several tissues, including endothelial cells of the BBB.
Cauzar Ali Khan, Nicolai Kirsch, Jürgen Brockmöller, Kyra‐Elisa Maria Redeker   +3 more
wiley   +1 more source

New potent muscarinic receptor ligands bearing the 1,4‐dioxane nucleus: Investigation on the nature of the substituent in position 2

Archiv der Pharmazie, Volume 357, Issue 10, October 2024.
The role of different substituents in position 2 of 6,6‐diphenyl‐1,4‐dioxane muscarinic receptor ligands in the affinity for the five muscarinic acetylcholine receptor (mAChR) subtypes was studied. The tertiary amine 9 and its eutomer (S)‐(–)‐9 showed picomolar affinity and biphasic curves for all mAChRs.
Gianfabio Giorgioni, Alessandro Bonifazi, Rosanna Matucci, Federica Matteucci, Alessandro Piergentili, Alessia Piergentili, Wilma Quaglia, Silvia Gervasoni, Giulio Vistoli, Serena Vittorio, Fabio Del Bello   +10 more
wiley   +1 more source

Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied [PDF]

, 2020
Muscarinic MT7 toxin is a highly selective and potent antagonist of the M 1 subtype of muscarinic receptor and acts by binding to an allosteric site. To identify the molecular determinants by which MT7 toxin interacts with this receptor in its free and ...
Catherine Marquer, Carole Fruchart-Gaillard, Enrico Stura, Denis Servent, Gilles Mourier, Nigel J M Birdsall   +5 more
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