Results 31 to 40 of about 10,564,162 (159)

Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor

British Journal of Pharmacology, Volume 181, Issue 14, Page 2338-2350, July 2024.
Background and Purpose Affinity‐based, selective orthosteric ligands for the muscarinic acetylcholine receptors (mAChRs) are difficult to develop due to high sequence homology across the five subtypes. Selectivity can also be achieved via the selective activation of a particular subtype or signalling pathway.
Ye Jiang, Mahmuda Yeasmin, Arisbel B. Gondin, Arthur Christopoulos, Celine Valant, Wessel A. C. Burger, David M. Thal   +6 more
wiley   +1 more source

PINZOTE de Musa balbisiana y Musa acuminata como Fuente de Fibras para Papel

, 2009
Este trabajo presenta una alternativa de uso industrial del pinzote (centro le oso del racimo de banano) como fuente de fibra para la estructuraci n de papel.
Turrado, Jos�, Sanju�n, Rub�n, Turrado, José, Saucedo, Alma R, Sanjuán, Rubén, Sulbaran, Belkis   +5 more
core   +1 more source

Second Near‐Infrared Activatable Nitric Oxide Releasing Nanoactuators for Photothermal Combinational Modulation of Epileptogenic Focus

Small Structures, Volume 5, Issue 5, May 2024.
A second near‐infrared (NIR‐II) activatable nitric oxide (NO) releasing nanoactuator is designed for modulating epileptogenic focus microenvironment. The nanoactuator exhibits strong photothermal conversion effect and photoinduced NO release to produce heat to kill abnormally discharging nerve cells in epileptogenic focus and downregulate P ...
Jiansheng Liu, Jiajia Li, Yanhui Shi, Anni Zhu, Mengbin Ding, Ningyue Yu, Yongkang Liu, Ping Wang, Jingchao Li, Yu Liu   +9 more
wiley   +1 more source

Muscarinic receptor binding and oxidative enzyme activities in the adult rat superior cervical ganglion: effects of 6-hydroxydopamine and nerve growth factor

, 1983
Administration of 6-hydroxydopamine to adult rats results in changes in the superior cervical ganglion similar to those noted after axotomy; namely, a decrease in muscarinic receptor binding and increases in activities of the oxidative enzymes of the ...
AA Jerkins, FC Kauffman, AM Dombrowski
core   +1 more source

Effect of the closed‐loop hippocampal low‐frequency stimulation on seizure severity, learning, and memory in pilocarpine epilepsy rat model

CNS Neuroscience &Therapeutics, Volume 30, Issue 3, March 2024.
Applying closed‐loop low‐frequency DBS, immediately after seizure detection, reduced the seizure severity, improved memory, and restored the changes in power, coherence, and coupling of the LFP oscillations in the hippocampus and medial prefrontal cortex. These effects assigned the low‐frequency DBS as an effective antiepileptic treatment.
Meysam Zare, Mahmoud Rezaei, Milad Nazari, Nastaran Kosarmadar, Mona Faraz, Victoria Barkley, Amir Shojaei, Mohammad Reza Raoufy, Javad Mirnajafi‐Zadeh   +8 more
wiley   +1 more source

Resolución CSPyGE N° 18/2021. Derogar la Resolución CSPyGE N° 97/2019 y su modificatoria, Resolución CSPyGE N° 02/2021. Aprobar el Régimen de Personal Docente.

, 2021
Fil: Consejo Superior de Programación y Gestión Estratégica (P). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución CSPyGE N° 18/2021. Derogar la Resolución CSPyGE N° 97/2019 y su modificatoria, Resolución CSPyGE N° 02/2021.
Consejo Superior de Programación y Gestión Estratégica (P)
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Pr¿cticas Educativas Abiertas como Factor de Innovaci¿n Educativa [PDF]

, 2012
7 p¿ginasEn el presente texto se hace alusi¿n a la necesidad_x000D_ de generar conocimiento, experiencia y experticia_x000D_ institucional y personal en la comunidad docente e_x000D_ investigadora en Educaci¿n Superior, para apoyar_x000D_ pr¿cticas ...
Chiappe Laverde, Andrés
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A comparison between the effects of scopolamine and methylscopolamine on exploration in rats [PDF]

, 1979
Two experiments compared the effects of equimolar doses (0.6 and 1.2 mg/kg) of scopolamine and its quaternary derivative methylscopolamine, on the behaviour of 50 male and 50 female albino rats in an exploration box comprising novel and familiar halves ...
Horsburgh, Ross James
core   +1 more source

Differential allosteric effects of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate-HCl (TMB-8) on muscarinic receptor subtypes

, 1989
TMB-8, a putative inhibitor of intracellular calcium mobilization, prevents the binding of the muscarinic ligand N-[3H]methylscopolamine. The inhibition was observed in four tissues from guinea pig; cortex, heart, pancreas, and ileum, representing Ml ...
Gordon, Richard K., Richard K. Gordon, Peter K. Chiang, Chiang, Peter K.   +3 more
core   +1 more source

N/A

, 1926
N/AEn los últimos años se ha empezado a notar la preocupación del gobierno por la creación de puesto veterinarios municipales que velan por el estado de salud de las carnes de consumo , la publicación de varis acuerdos tendientes a higienizar las ...
Mejía, Santiago
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