Results 81 to 90 of about 13,188 (213)

N-nitrosamine (TRGS 552)

NIPPON GOMU KYOKAISHI, 2010
TRGS 552 in Germany regulates certain N-nitrosamine compounds in rubber articles.N-nitrosamines are carcinogenic substances produced by reaction between nitrogen oxides and amines.Amines for the rubber industry has been used as a raw material such as rubber accelerator, is essential for rubber materials.N-nitrosamines are not regulated in Japan, but ...
openaire   +2 more sources

CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer [PDF]

, 2012
We investigated a possible association between alcoholism, cigarette smoking, obesity and CYP2E1 RsaI and 96-bp insertion genetic polymorphisms with risk for colorectal cancer (CRC). Patients with CRC (70 women and 61 men) were matched for gender and age
Barao, Katia, Felipe, Aledson Vitor, Forones, Nora Manoukian, Pimenta, Celia Aparecida Marques, Silva, Tiago Donizetti da   +4 more
core   +2 more sources

Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation

iMetaOmics, Volume 3, Issue 1, March 2026.
This review elucidates the critical crosstalk between the urobiome and bladder cancer (BCa), mapping the landscape from ecological dysbiosis to clinical translation. We synthesize emerging evidence on microbial signatures that distinguish BCa patients, exploring key carcinogenic mechanisms including chronic inflammation, genotoxicity, and the gut ...
Haoxiang Xu, Zhibiao Li, Lin Yang, Jun Zheng, Weijia Li, Rulin Liao, Wenxue Huang, Boyuan Sun, Zhuohang Li, Cunzhen Ma, Xunguo Yang, Zongwei Wang, Jie Zhao, Bisheng Cheng, Peng Wu   +14 more
wiley   +1 more source

N-nitrosamine risk assessment in pharmaceuticals: Where are we from a regulatory point of view in 2025?

Journal of Pharmaceutical and Biomedical Analysis Open
N-nitrosamines have been a concern for decades due to their potential mutagenicity and widespread occurrence across various matrices. While evidence suggests carcinogenicity in animals, their potential carcinogenicity in humans has prompted their initial
Yue Zhang, Joëlle Widart, Eric Ziemons, Philippe Hubert, Cédric Hubert   +4 more
doaj   +1 more source

Cytochrome P450 2E1 variable number tandem repeat polymorphisms and health risks: A genotype-phenotype study in cancers associated with drinking and/or smoking [PDF]

, 2012
Cytochrome P450 2E1 (CYP2E1) is one of the main enzymes involved in the oxidation of ethanol and in the transformation of a number of potentially dangerous compounds. It has various polymorphic sites, one of which is a variable number tandem repeat (VNTR)
CARADONNA, Fabio, CATANZARO, Irene, GIACALONE, Antonio Mario, MONTALTO, Giuseppe, NASELLI, Flores, SAVERINI, Marghereth   +5 more
core   +1 more source

Reduced Nitrates/Nitrites and Natural Additives in Organic Fermented Dry‐Cured Sausages: Effects on Microbiological Safety, Quality, and Consumer Acceptance

Journal of Food Science, Volume 91, Issue 3, March 2026.
ABSTRACT This study examines hydroxytyrosol (HXT), a natural antioxidant, as a partial substitute for curing agents in fermented dry‐cured organic sausages. Increasing health concerns regarding nitrates/nitrites, along with EU efforts to reduce their use, highlight the need for alternatives.
Immaculada Argemí‐Armengol, Guillermo Ripoll, Daniel Villalba, Javier Álvarez‐Rodriguez   +3 more
wiley   +1 more source

Influence of tobacco smoke on the pharmacokinetics of citalopram and its enantiomers [PDF]

, 2012
The purpose of this study was to evaluate the influence of tobacco smoke on the pharmacokinetics of citalopram (CIT) and desmethylcitalopram (DCIT) and its enantiomers on an animal model.
Florek, Ewa, Jawień, Wojciech, Kulza, Maksymilian, Majcherczyk, Jagoda, Piekoszewski, Wojciech, Seńczuk-Przybyłowska, Monika   +5 more
core  

Heat‐Not‐Burn Tobacco Aerosols Induce Immune Dysregulation and Barrier Disruption Comparable to Conventional Cigarettes

Allergy, Volume 81, Issue 3, Page 781-795, March 2026.
Comparative analysis between cigarette smokers and HnB users revealed similar inflammatory lung function parameters and immunophenotypic patterns. Cigarette smoke and HnB aerosol had an impact on ECM through divergent downstream pathways. Exposed to Cigarette smoke and HnB aerosol caused comparative TJ weakening in the epithelial barrier.
Dilara Karaguzel, Alicja Walewska, Basak Ezgi Sarac, Marlena Tynecka, Kinga Bondarczuk, Agnieszka Tarasik, Dariusz Kisiel, Karolina Partyk, Damian Pogodziński, Bartosz Hanczaruk, Alicja Toczydlowska, Cagla Bicakci, Doga Oztabak, Magdalena Niemira, Adam Kretowski, Marlena Dubatowka, Natalia Ogrodnik, Malgorzata Chlabicz, Pawel Sowa, Karol Kaminski, Marcin Moniuszko, Andrzej Eljaszewicz, Cagatay Karaaslan   +22 more
wiley   +1 more source

Characteristics of Se'i (Rotenesse Smoked Meat) Treated with Coconut Shell Liquid Smoked and Citrus Aurantifolia Extract [PDF]

, 2015
The objective of this study was to investigate the effect of Citrus aurantifolia extract (CAE), coconut shell liquid smoke (CSLS) and the combination of CAE and CSLS (CACS) on se'i characteristics.
Deno Ratu, M.R, Jelantik, I. G. (I), Lalel, H. J. (H), Malelak, G. E. (Gemini), Sipahelut, G. M. (G)   +4 more
core  

Quercetin Enhances Gastric Nitric Oxide Formation and Potentiates the Antihypertensive Effects of Oral Nitrite Administration

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Oral nitrite supplementation enhances nitric oxide (NO) bioavailability and lowers blood pressure. Quercetin may facilitate the reduction of nitrite to NO. However, the combined effects of nitrite and Quercetin on gastric NO formation and blood pressure have not been explored.
Mila Silva‐Cunha, Sandra O. Conde‐Tella, Macário A. Rebelo, Isadora L. M. Kemmer, Ana K. Lima‐Silva, Ediléia de S. P. Caetano, Jose E. Tanus‐Santos   +6 more
wiley   +1 more source