Results 61 to 70 of about 1,636 (167)

USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53

Cell Proliferation, Volume 58, Issue 5, May 2025.
Our findings demonstrated that USP33 deubiquitinates p53 and regulates its stability, and moreover, DNA damage can stabilise p53 through enhancing its association with USP33, leading to strong DNA damage response (DDR). However, USP33 deficiency results in defective DDR, facilitating DEN‐induced hepatocarcinogenesis in hepatocyte‐specific USP33 KO mice.
Yuqi Zhu, Zixiang Chen, Kaifeng Niu, Mengge Li, Yuchun Deng, Ji Zhang, Di Wei, Jiaqi Wang, YongLiang Zhao   +8 more
wiley   +1 more source

Nutritional Composition, Phytochemical Profile, Extraction Methods of Bioactive Components, and Health Benefits of Terminalia Arjuna Bark

eFood, Volume 6, Issue 2, April 2025.
The plant's bark is rich in polyphenols, particularly gallic acid and ellagic acid derivatives, which are powerful antioxidants. These antioxidants can protect cells from oxidative stress and may help prevent degenerative diseases. Additionally, Terminalia arjuna contains triterpenoids like arjunolic acid and arjunic acid, which have various ...
Hafsa Tahir, Muhammad Nadeem Akhtar, Ashok Kumar Bishoyi, Gaurav Sanghvi, Musarrat Rasheed, Muhammad Afzaal, Ali Imran, Farhan Saeed, Neeraj Khare, Faiyaz Ahmed, Oshin Sahni, Huda Ateeq, Fakhar Islam, Abdela Befa Kinki   +13 more
wiley   +1 more source

Protective role of Methanol extract of Phyllanthus Polyphyllus against N-nitrosodiethylamine induced liver tumor in rat

Bangladesh Journal of Pharmacology, 2010
The protective role of methanol extract of Phyllanthus polyphyllus was evaluated in N-nitrosodiethylamine-induced experimental liver tumor in male Wistar albino rats.
Naina Mohamed Pakkir Maideen, Ravichandiran Velayutham and Gobinath Manavalan
doaj  

Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints

Environmental and Molecular Mutagenesis, Volume 66, Issue 4, Page 172-184, April 2025.
ABSTRACT The benchmark dose (BMD) approach constitutes the most effective and pragmatic strategy for the derivation of a point of departure (PoD) for comparative potency analysis, risk assessment, and regulatory decision‐making. There is considerable controversy regarding the most appropriate benchmark response (BMR) for genotoxicity endpoints.
Paul A. White, Guangchao Chen, Nikolai Chepelev, Madison A. Bell, Lauren R. Gallant, George E. Johnson, Andreas Zeller, Marc A. Beal, Alexandra S. Long   +8 more
wiley   +1 more source

Pomegranate juice recuperates N’-Nitrosodiethylamine-induced kidney injury: evidence from biochemical and histological approaches

Journal of Basic and Applied Zoology
Background Pomegranate is considered as one of the oldest elixirs having various properties. Renal fibrosis is a preliminary sign of pathological degradation in most ailments related to kidney.
Hadiya Husain, Riaz Ahmad
doaj   +1 more source

The effectiveness of ursolic acid niosomes with chitosan coating for prevention of liver damage in mice induced by n-nitrosodiethylamine. [PDF]

Sci Rep, 2022
Miatmoko A, Faradisa AA, Jauhari AA, Hariawan BS, Cahyani DM, Plumeriastuti H, Sari R, Hendradi E.   +7 more
europepmc   +1 more source

AFFINITY OF LIGNIN PREPARATIONS TOWARDS GENOTOXIC COMPOUNDS

BioResources, 2009
The carcinogenicity and mutagenicity of chemicals may be modulated by other chemicals, including those prepared by organic synthesis. Consid-ering the several drawbacks of synthetic compounds vis-a-vis the human organism, the lignin biomass component was
Božena Košíková, Elena Sláviková, Juraj Lábaj   +2 more
doaj  

Valine supplement recuperates N′-nitrosodiethylamine-induced liver injury in rodents via reducing oxidative stress and restoring lobular architecture

Journal of Basic and Applied Zoology
Background N΄-Nitrosodiethylamine (NDEA) generates hepatotoxicity and, can induce mutations and cancers. NDEA potentially induces liver fibrosis and tumors in rodents which imitates human disease.
Akbar Hussain, Mohd Danish, Riaz Ahmad
doaj   +1 more source

L-Theanine-Treated Adipose-Derived Mesenchymal Stem Cells Alleviate the Cytotoxicity Induced by N-Nitrosodiethylamine in Liver. [PDF]

Tissue Eng Regen Med, 2022
Lai YJ, Sung YT, Lai YA, Chen LN, Chen TS, Chien CT.   +5 more
europepmc   +1 more source

Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status. [PDF]

Asian Pac J Cancer Prev, 2022
Salama OA, Moawed FS, Moustafa EM, Kandil EI.   +3 more
europepmc   +1 more source