Results 71 to 80 of about 1,636 (167)

Ability of Allium cepa L. root tips and Tradescantia pallida var. purpurea in N-nitrosodiethylamine genotoxicity and mutagenicity evaluation

Anais da Academia Brasileira de Ciências, 2010
N-nitroso compounds, such as N-nitrosodiethylamine (NDEA), can be formed by the reaction of secundary amines with nitrosating agents, and are suspected to be involved in tumors in humans.
Claudia R. de Rainho, Andréa Kaezer, Claudia A.F. Aiub, Israel Felzenszwalb   +3 more
doaj   +1 more source

Author Correction: Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma. [PDF]

Sci Rep, 2022
Younis NS, Ghanim AMH, Saber S.
europepmc   +1 more source

Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.

Experimental oncology, 2007
Aim: To study the effect of silymarin on the levels of tumor markers and MDA (malondialdehyde) ??? DNA adduct formation during N-nitrosodiethylamine induced hepatocellular carcinoma in male Wistar albino rats. Methods: The levels of AFP, CEA and activities of liver marker enzymes in serum, MDA-DNA immunohistochemistry were done according to standard ...
Ramakrishnan, G., Augustine, T.A., Jagan, S., Vinodhkumar, R., Devaki, T.   +4 more
openaire   +2 more sources

Influence of ethanolic extract of Allium sativum on TP53 gene and its anticancer potential in N-Nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in male albino rats. [PDF]

Iran J Basic Med Sci, 2022
Ogar GO, Minari JB, Bello AJ, Chiwetalu J, Omogunwa OE, Oshikoya OS, Otaru MT, Anyanele CA.   +7 more
europepmc   +1 more source

Four functional genotoxic marker genes (Bax, Btg2, Ccng1, and Cdkn1a) discriminate genotoxic hepatocarcinogens from non-genotoxic hepatocarcinogens and non-genotoxic non-hepatocarcinogens in rat public toxicogenomics data, Open TG-GATEs

Genes and Environment
Background Previously, Japanese Environmental Mutagen and Genome Society/Mammalian Mutagenicity Study Group/Toxicogenomics Study Group (JEMS/MMS toxicogenomic study group) proposed 12 genotoxic marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15 ...
Chie Furihata, Takayoshi Suzuki
doaj   +1 more source

Inhibition by Phyllanthus amarus of Hepatocarcinogenesis Induced by N-Nitrosodiethylamine.

Journal of Clinical Biochemistry and Nutrition, 1998
The extract of Phyllanthus amarus (Syn. P. niruri) was found to be a potent inhibitor of the hepatocarcinogenesis induced by N-nitrosodiethylamine (NDEA). None of the P. amarus extract-treated animals developed any tumors even 32 weeks after the NDEA administration, whereas all of the animals died due to tumor burden in the control group.
JOY, K.L., KUTTAN, Ramadasan
openaire   +2 more sources

Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer

Cell Reports
Summary: The integrated stress response (ISR) is activated in response to intrinsic and extrinsic stimuli, playing a role in tumor progression and drug resistance.
Hongmiao Dai, Bo Wu, Yingwei Ge, Yang Hao, Lijie Zhou, Ruolin Hong, Jinhao Zhang, Wenli Jiang, Yuting Zhang, Hongchang Li, Lingqiang Zhang   +10 more
doaj   +1 more source

Quantification, antioxidant, in-silico molecular docking and anti-hepatocellular carcinoma activity of Sepia ink polysaccharides prepared from Sepia pharaonis

Future Journal of Pharmaceutical Sciences
Background Sepia pharaonis, a marine cuttlefish, contains bioactive compounds such as posterior salivary gland toxin with medicinal potential, though its pharmacological effects are largely unknown. This research is one of the first comprehensive studies
Sandhanam Kuppusamy, Bedanta Bhattacharjee, Abarnadevika Alagiri, Sumithra Mohan, Ram Kumar Sahu, Abhishek Bhattacharjee, Chitra Vellapandian   +6 more
doaj   +1 more source

N-nitrosamines in karst groundwaters in southwestern China: Risks and implications for drinking water safety

Emerging Contaminants
Groundwater is a vital drinking water source for populations in remote karst regions. However, the highly developed karst tube systems facilitate the infiltration of surface wastewater containing N-nitrosamines, raising concerns about groundwater safety.
Xiongwei Gu, Liwei Xu, Xin Huang, Yingjie Chen, Yan Li, Yuanyu Shan, Xiaoyu Yan, Zhaojue Liu, Honghu Zeng, Wenwen Chen, Huanfang Huang   +10 more
doaj   +1 more source

Dexmedetomidine protects against N-Nitrosodiethylamine induced acute hepatic damage by modulating autophagy and apoptosis through SIRT1

Anesthesiology and Perioperative Science
Purpose Dexmedetomidine (DEX) has been extensively studied for its protective effects on multiple organs, primarily attributed to its anti-inflammatory and anti-apoptotic properties.
Ruixin Wu, Sailan Tang, Aoxue Xu, Qi Xue, Shuwen He, Qizhi Liao, Chanjuan Chen, Dachen Zhou, Xianwen Hu, Nianliang Zhang, Gang Li, Ye Zhang, Chunxia Huang   +12 more
doaj   +1 more source