Results 51 to 60 of about 1,636 (167)

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, Volume 66, Issue S2, Page 101-120, December 2025.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, Volume 66, Issue S2, Page 121-143, December 2025.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

ASH2L‐K312‐Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma

Advanced Science, Volume 12, Issue 40, October 27, 2025.
In this study, ASH2L‐K312‐lac is identified as a critical driver that promotes the malignant progression of hepatocellular carcinoma (HCC). Furthermore, through a comprehensive series of cell biological and molecular biological experiments, integrated with diverse animal models and systematic application of high‐throughput sequencing technologies, it ...
Hexu Han, Shuai Wang, Lixing Ma, Haimeng Yin, Xinxiang Cheng, YiFan Wang, Suqin Xia, Yi Zhang, Yue Zhang, Rong Zhu, Cuixia Liu, Dakun Zhao, Xiangqian Gu, He Zhu, Yin Yuan   +14 more
wiley   +1 more source

Combined Maternal and Paternal Low‐Dose N‐Nitrosodimethylamine Exposure: Maternal Alterations and Developmental Toxicity in Rats

Birth Defects Research, Volume 117, Issue 10, October 2025.
ABSTRACT Background N‐Nitrosodimethylamine (NDMA) is an organic xenobiotic compound and a well‐established mutagen and carcinogen. Its potential to cause reproductive and developmental toxicity at low, relevant doses is unclear. This study evaluated the effects of combined maternal and paternal NDMA exposure, both preconceptionally and during gestation,
Julia Tavares Alves, Luara Magalhães, Julia Vitoria Francisco de Aquino, Otávio Galassi Vitale, Giovanna Ferrari Rosalem, Giovanna Kugel Marraschi, Reggina Lorena Mellado Castro, Sara Tawany Caetano dos Santos, Livia Trippe Nagaoka, Julia Stein, Hamilton Hisano, Bárbara Campos Jorge, Arielle Cristina Arena   +12 more
wiley   +1 more source

Protective effects of dieckol on N-nitrosodiethylamine induced hepatocarcinogenesis in rats

Biomedicine & Pharmacotherapy, 2016
Dieckol (DEK) is a naturally occuring phlorotannins found in marine brown algae Ecklonia cava which is attributed with various pharmacological properties. This study was aimed to investigate the protective role of DEK on N-Nitrosdiethylamine (NDEA) induced rat hepatocarcinogenesis.
Velayutham, Sadeeshkumar, Arul, Duraikannu, Samuthrapandian, Ravichandran, Wilson Sylvester, Fredrick, Ramar, Sivaperumal, Paulrasu, Kodisundaram   +5 more
openaire   +2 more sources

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Modulatory mechanisms of copperII-albumin complex toward N-nitrosodiethylamine-induced neurotoxicity in mice via regulating oxidative damage, inflammatory, and apoptotic signaling pathways

Ecotoxicology and Environmental Safety
N-nitrosodiethylamine (ND) is an extremely toxic unavoidable environmental contaminant. CopperII-albumin (CuAB) complex, a newly developed Cu complex, showed antioxidant and anti-inflammatory potential.
Obeid Shanab, Laila Mostafa, Ahmed Abdeen, Rania Atia, Ahmed Y. Nassar, Mohammed Youssef, Samah F. Ibrahim, Zainab M. Maher, Florin Imbrea, Liana Fericean, Khaled Ghareeb, Tabinda Hasan, Heba I. Ghamry, Reem T. Atawia, Omar Sadeq, Afaf Abdelkader   +15 more
doaj   +1 more source

Evaluating the Role of Autochthonous Lactic Acid Bacteria and Ripening Conditions on Nitrosamine Inhibition in Sucuk Over Storage Time

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
The autochthonous lactic acid bacteria inhibited NDMA. Differences were noted among strains in terms of acid formation. At the end of ripening, slow ripening yields higher residual nitrite than rapid ripening. ABSTRACT The study determined the effects of lactic acid bacteria (LAB) (LS: Latilactobacillus sakei S15, LP: Lactiplantibacillus plantarum S91,
Selen Sallan, Zeynep Feyza Yılmaz Oral, Yağmur Akyol, Güzin Kaban, Mükerrem Kaya   +4 more
wiley   +1 more source

Effect of Route of Administration on the Carcinogenic Action of Diethylnitrosamine (N-Nitrosodiethylamine) [PDF]

British Journal of Cancer, 1964
Effect of Route of Administration on the Carcinogenic Action of Diethylnitrosamine ( N -Nitrosodiethylamine)
openaire   +2 more sources

Assessment and Risk Analysis of Nitrosamines in Sausages From Northern Iran

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study evaluates nitrosamine levels in chicken and red meat sausages from northern Iran, identifying health risks for consumers. Using high‐performance liquid chromatography (HPLC), significant variations in nitrosamine concentrations were observed, with red meat sausages showing the highest levels.
Mohammad Sadegh Allahkhah, Mohammadhosein Movassaghghazani   +1 more
wiley   +1 more source