Results 31 to 40 of about 1,636 (167)

Chemopreventive effect of omega- 3 fatty acids in N-nitrosodiethylamine Induced hepatocellular carcinoma in rats [PDF]

Benha Veterinary Medical Journal, 2016
Liver cancer, predominantly hepatocellular carcinoma (HCC), represents a complex and fatalmalignancy driven primarily by oxidative stress and inflammation.
Eman Sarhan, Aziza Amin, Tahya Esmeal, Samy Hussein   +3 more
doaj   +1 more source

Phytofabrication of Silver nanoparticles: Novel Drug to overcome hepatocellular ailments

Toxicology Reports, 2018
This study aimed to treat hepatocellular ailments with biologically prepared silver nanoparticle (AgNPs). AgNPs were formulated using Morus alba leaf extract and their synthesis and characterization were determined by UV–visible spectroscopy ...
Asha Singh, Mohd Yaqoob Dar, Beenu Joshi, Bhawna Sharma, Sadhana Shrivastava, Sangeeta Shukla   +5 more
doaj   +1 more source

Metformin Prevents NDEA-Induced Memory Impairments Associated with Attenuating Beta-Amyloid, Tumor Necrosis Factor-Alpha, and Interleukin-6 Levels in the Hippocampus of Rats

Biomolecules, 2023
N-nitrosodiethylamine (NDEA) is a potential carcinogen known to cause liver tumors and chronic inflammation, diabetes, cognitive problems, and signs like Alzheimer’s disease (AD) in animals. This compound is classified as probably carcinogenic to humans.
Teresa Ponce-Lopez, José Antonio González Álvarez Tostado, Fernando Dias, Keren Happuck Montiel Maltez   +3 more
doaj   +1 more source

Development of a sensitive and stable GC-MS/MS method for simultaneous determination of four N-nitrosamine genotoxic impurities in sartan substances

Journal of Analytical Science and Technology, 2021
Recently, N-nitrosamines have been unexpectedly found in generic sartan products. Herein, we developed a sensitive and stable GC-MS/MS method with multiple reactions monitoring mode for the simultaneous determination of four N-nitrosamines in sartan ...
Jie Liu, Bin Xie, Binliang Mai, Qiang Cai, Rujian He, Dong Guo, Zhifeng Zhang, Jun Fan, Weiguang Zhang   +8 more
doaj   +1 more source

Effect of Black Garlic on Microbiological Properties, Lipid Oxidation, Residual Nitrite, Nitrosamine Formation and Sensory Characteristics in a Semi-Dry Fermented Sausage

Foods, 2023
This study was conducted with the aim of determining the effects of different black garlic (BG) levels (1%, 2% and 3%) on quality characteristics of a semi-dry fermented sausage (heat-treated sucuk). In addition, the effect of cooking time (0, 1 or 3 min
Begüm Akansel, Zeynep Feyza Yılmaz Oral, Selen Sallan, Güzin Kaban, Mükerrem Kaya   +4 more
doaj   +1 more source

Regulation of Endoplasmic Reticulum Stress Suppresses Early Pro‐Tumorigenic Events During N‐Nitrosodiethylamine‐Induced Hepatocarcinogenesis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
Schematic illustration of the effect of BIX in attenuating the initiation stage of hepatocarcinogenesis. BIX pre‐treatment mitigated N‐nitrosodiethylamine‐induced ER stress, DNA damage, and downstream pro‐tumorigenic events during the initiation phase. It preserved DNA repair capacity, reduced inflammation and cellular proliferation, thereby inhibiting
Maya P. Shetty, Smita Hegde, Sanjay Bharati   +2 more
wiley   +1 more source

Development and Validation of a Method for the Semi-Quantitative Determination of N-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector

Applied Sciences, 2021
A novel HPLC method with fluorimetric detection was developed for the determination of potentially carcinogenic N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) in active pharmaceutical ingredient enalapril maleate.
Dariusz Boczar, Elżbieta Wyszomirska, Beata Zabrzewska, Anna Chyła, Katarzyna Michalska   +4 more
doaj   +1 more source

A Robust and Universal LC–MS/MS Method for Determination of N‐Nitrosodimethylamine in Pharmaceuticals Using a C30 Column

Journal of Separation Science, Volume 49, Issue 6, June 2026.
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
Byungchan An, Unyong Kim, Sumin Seo, Jiyu Kim, Chohee Jeong, Woojin Jeong, Eunjin Ko, Juhyeon Kim, Hyun‐Deok Cho, Sang Beom Han   +9 more
wiley   +1 more source

Ecotoxicological risk assessment of N-nitrosamines to Selenastrum capricornutum in surface waters: Insights into toxicity mechanisms and environmental Implications

Ecotoxicology and Environmental Safety
N-nitrosamines, one of the most common nitrogen-containing organic compounds in freshwater systems such as rivers or reservoirs, are toxic and carcinogenic to human.
Decai Liu, Litang Qin, Honghu Zeng, Yi Liang, Yanpeng Liang, Yingjie Chen, Huanfang Huang, Wenwen Chen   +7 more
doaj   +1 more source

Protective effects of epicatechin on the oxidation and N-nitrosamine formation of oxidatively stressed myofibrillar protein

International Journal of Food Properties, 2019
The present study investigated the protective effects of the polyphenol epicatechin on the protein structural changes, gel properties and N-nitrosodiethylamine (NDEA) formation of oxidatively stressed myofibrillar protein (MP).
Ling Li, Hui Ji
doaj   +1 more source