Results 11 to 20 of about 1,636 (167)

Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats

Journal of Pharmacy and Bioallied Sciences, 2015
Background: Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome
R Jayaprakash, V Ramesh, M P Sridhar, C Sasikala   +3 more
doaj   +2 more sources

Mechanisms of hepatoprotective effects of white and black garlic extracts against preneoplastic lesions induced by N-nitrosodiethylamine in rats [PDF]

Journal of HerbMed Pharmacology, 2021
Introduction: Garlic has many pharmacological properties such as antibacterial, anti-inflammatory, and antioxidant activities. This study aimed to investigate the possible mechanisms of the hepatoprotective effect of white garlic extract (WGE) and black ...
Mostafa Abbas Shalaby, Rehab Ali Ghandour, Shimaa Ramadan Imam   +2 more
doaj   +1 more source

N-nitrosodiethylamine induces inflammation of liver in mice

Journal of Basic and Clinical Physiology and Pharmacology, 2021
Abstract Objectives For designing early treatment for liver cancer, it is important to prepare an animal model to evaluate cancer prevention treatment by using inflammation disease. The hepatocarcinogenic N-Nitrosodiethylamine (NDEA) has been reportedly able to produce free radicals that cause ...
Devy Maulidya Cahyani, -, Andang Miatmoko, -, Berlian Sarasitha Hariawan, -, Kusuma Eko Purwantari, -, Retno Sari, -   +4 more
openaire   +3 more sources

INHIBITION OF EXPERIMENTAL CARCINOGENESIS BY THE BIOACTIVE NATURAL PRODUCT BIOBRAN. [PDF]

Journal of Plant Protection and Pathology, 2016
To investigate  the  protective effects of  biobran against N-nitrosodiethyamine (NDEA) and carbon tetrachloride CCl4-induced hepatocarcinogenesis in rats.
Reem Othman, Doaa Ali, Nariman Badr El-Din   +2 more
doaj   +1 more source

Anticancer property of Selaginella bryopteris (L.) Bak. against hepatocellular carcinoma in vitro and in vivo

Phytomedicine Plus, 2022
Background: Hepatocellular carcinoma (HCC) is the most common and leading cause of cancer-related mortality worldwide. It has limited therapeutic options and side effects caused by current treatment methods.
Lal Chand Pal, Arti Gautam, Veena Pande, Ch V Rao   +3 more
doaj   +1 more source

Sustainability in Analytical Chemistry Illustrated by Pharmaceutical Nitrosamine Testing. [PDF]

Electrophoresis
ABSTRACT Following the valsartan scandal in 2018, the testing of drug substances and drug products for N‐nitrosamines has become a critical and mandatory quality control measure. The European Pharmacopoeia chapter 2.5.42 currently describes three analytical methods for this purpose: HPLC–MS/MS, GC–MS, and GC–MS/MS.
Bredendiek F, Schmidtsdorff S, Parr MK.
europepmc   +2 more sources

Salmonella typhimurium TA100 and TA1535 and E. coli WP2 uvrA are highly sensitive to detect the mutagenicity of short Alkyl-N-Nitrosamines in the Bacterial Reverse Mutation Test

Toxicology Reports, 2022
Humans are exposed to low levels of N-nitrosamines via different sources. N-Nitrosamines have recently been detected as impurities in various marketed drugs and they are known mutagenic carcinogens belonging to the cohort of concern as referred to in the
Frank Bringezu, Stephanie Simon
doaj   +1 more source

Degradation of N-Nitrosodiethylamine in aqueous solution by gamma-irradiation

Environmental Technology, 2020
N-Nitrosodiethylamine (NNDEA) is a toxic compound which is affranchised into the medium mostly via industrial wastewater. For the investigation of degradation mechanism of NNDEA, the aqueous solutions of NNDEA were exposed to Advanced Oxidation processes (AOP's) such as gamma-irradiation, ozonation, UV irradiation and UV/Ozone (ozone effect) and UV ...
Masoomeh Mehrnia, Murat Torun, Dilek Şolpan   +2 more
openaire   +3 more sources

Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma

Molecular Cancer, 2010
Background The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field.
Heindryckx Femke, Mertens Koen, Charette Nicolas, Vandeghinste Bert, Casteleyn Christophe, Van Steenkiste Christophe, Slaets Dominique, Libbrecht Louis, Staelens Steven, Starkel Peter, Geerts Anja, Colle Isabelle, Van Vlierberghe Hans   +12 more
doaj   +1 more source

Losartan API and Nitrosamines Impurities-Stability Profile Investigation Using HPLC, LC-MS, and In Silico Assessment. [PDF]

J Sep Sci
ABSTRACT Nitrosamines are potent genotoxic impurities with well reported mutagenic and carcinogenic effects. Their presence has been detected in several pharmaceutical products among them losartan, an angiotensin II receptor blocker. Considering the risks already reported for these impurities, the present study aimed to investigate the influence of ...
Martini PRR, Machioli LF, Santos BPD, Oliveira TF, Paula FR, Paim CS, Mendez ASL.   +6 more
europepmc   +2 more sources