Results 1 to 10 of about 1,617 (151)

Exacerbation of N-nitrosodiethylamine Induced Hepatotoxicity and DNA Damage in Mice Exposed to Chronic Unpredictable Stress [PDF]

Frontiers in Pharmacology, 2017
Psychological stress contributes to increased susceptibility to a number of diseases including cancer. The present study was designed to assess the effect of chronic unpredictable stress on N-nitrosodiethylamine induced liver toxicity in terms of in vivo
Sabiha Fatima, Athanasios Alexiou, Naheed Banu   +2 more
exaly   +4 more sources

Analysis of N -nitrosodiethylamine by ion chromatography coupled with UV photolysis pretreatment [PDF]

Journal of Food and Drug Analysis, 2016
Nitrosamines such as N-nitrosodiethylamine (NDEA) are commonly detected by spectrophotometry after photolysis and Griess reaction (PG) in food industries for lower cost. Results of this research indicate that NDEA decays rapidly under UV irradiation, and concentrations of the generated NO2- and NO3- ions vary with photolysis conditions.

exaly   +4 more sources

Protective effect of Genistein against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in Swiss albino rats [PDF]

Journal of Pharmaceutical Analysis, 2015
In the present study, we studied the effect of Genistein against the hepatotoxicity induced by N-nitrosodiethylamine (NDEA). NDEA is present in almost all kinds of food stuff and has been reported to be a hepatocarcinogen.
Fahad Ali, Rahul, Falaq Naz, Smita Jyoti, Yasir Hasan Siddique   +4 more
doaj   +2 more sources

Protective Effects of Garlic Oil on Hepatocarcinoma Induced by N-Nitrosodiethylamine in Rats [PDF]

International Journal of Biological Sciences, 2012
To investigate the protective effects and the possible mechanisms of garlic oil (GO) against N-nitrosodiethylamine (NDEA)-induced hepatocarcinoma in rats, Wistar rats were gavaged with GO (20 or 40 mg/kg) for 1 week, and then were gavaged with GO and ...
Cui-Li Zhang, Tao Zeng, Xiu-Lan Zhao, Li-Hua Yu, Zhen-Ping Zhu, Ke-Qin Xie
doaj   +2 more sources

Comprehensive Assessment of Nitrosamine Formation in Meat Products Using UHPLC-HRMS: Analytical Challenges and Potential Dietary Implications [PDF]

Molecules
Nitrosamines (NAs) pose a risk due to their carcinogenic properties, especially in processed and cured meats where nitrites and nitrates are widely used.
Tiziana Nardin, Jakob Franceschini, Francesca Martinelli, Elena Franciosi, Roberto Larcher   +4 more
doaj   +2 more sources

Oral curative therapeutic study of N-nitrosodiethylamine-induced mouse liver damage of chitosan-coated ursolic acid niosomes [PDF]

Scientific Reports
Ursolic acid (UA), classified as a Biopharmaceutics Classification System (BCS) class IV compound, exhibits hepatoprotective, anti-inflammatory, and anticancer activities.
Andang Miatmoko, Ahmad Aziz Jauhari, Amelia Anneke Faradisa, Devy Maulidya Cahyani, Berlian Sarasitha Hariawan, Joni Susanto, Thaigarajan Parumasivam, Esti Hendradi, Retno Sari   +8 more
doaj   +2 more sources

Protective Effect of Prosopis cineraria Against N-Nitrosodiethylamine Induced Liver Tumor by Modulating Membrane Bound Enzymes and Glycoproteins [PDF]

Advanced Pharmaceutical Bulletin, 2012
Purpose: The objective of the present study was to evaluate the protective effect of methanol extract of Prosopis cineraria (MPC) against N-nitrosodiethylamine (DEN, 200mg/kg) induced Phenobarbital promoted experimental liver tumors in male Wistar rats ...
Naina Mohamed Pakkir Maideen, Ravichandiran Velayutham, Gobinath Manavalan   +2 more
doaj   +2 more sources

Analysis and risk assessment of nitrosamines in sartans using GC-MS and Monte Carlo simulation [PDF]

Scientific Reports
The precise detection of nitrosamines at very low levels in various substances is crucial because of their known toxicity and potential to cause genetic mutations.
Fatemeh Shomali, Zahra Talebpour, Ghazaleh Abedi, Nilufar Mousavi, Shiva Mokhtarifar, Marjan Kohandani, Vahideh Mahdavi, Noushin Adib   +7 more
doaj   +2 more sources

Immunohistochemical, histopathological study and chemoprotective effect of Solanum nigrum in N-nitrosodiethylamine-induced hepatocellular carcinoma in Wistar rats [PDF]

Veterinary World, 2018
Background and Aim: Cancer is a devastating disease with a severe impact on the physical and psychological well-being of patients. Hepatocellular carcinoma (HCC) has been reported in various species of animals including dogs, cats, sheep, and pigs.
G. M. Akshatha, S. K. Raval, G. M. Arpitha, S. H. Raval, D. J. Ghodasara   +4 more
doaj   +2 more sources

Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats. [PDF]

J Cancer Res Clin Oncol, 2010
Chemoprevention is an effective approach to control hepatocarcinogenesis. Bacoside A, the active constituent of Bacopa monniera Linn., is anticipated to play a role in chemoprevention of liver cancer.In the present study, we investigated the chemopreventive effect of bacoside A against N-nitrosodiethylamine-induced hepatocarcinogenesis in an animal ...
Janani P, Sivakumari K, Geetha A, Ravisankar B, Parthasarathy C.   +4 more
europepmc   +3 more sources