Results 61 to 70 of about 26,600 (182)

Severe Pediatric MOGAD‐Associated ADEM With Persistent Neurological Morbidity and Later‐Onset Epilepsy of Uncertain Etiology: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This report describes a 7‐year‐old boy with MOGAD presenting as severe ADEM with fever, encephalopathy, seizures, markedly elevated intracranial pressure, diffuse multifocal MRI abnormalities, and serum MOG‐IgG positivity. He required intravenous corticosteroids, plasma exchange, IVIG, and tocilizumab, followed by rehabilitation and ...
Desiree‐Anne Ramsaran, Garrett Gianneschi, Janet Elgallab   +2 more
wiley   +1 more source

PorA typing of Neisseria meningitidis isolates from Iranian children for vaccine design

Vaccine Research, 2018
Introduction: As the causative agent of meningitis, Neisseria meningitidis has different serogroups. The purpose of this study was to investigate the molecular properties of N. meningitidis strains among Iranian cases. Methods: 450 samples were collected
P Afrough, M Vosogh, MR Asadi Karam, A Behrouzi, G Mardani, SD Siadat   +5 more
doaj  

CRISPR‐Cas9 in Cancer Therapy: Overcoming Delivery Barriers and Off‐Target Effects for Clinical Translation

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims CRISPR‐Cas9 gene editing has transformed molecular biology and has great potential as a therapeutic tool for cancer and many other human diseases. This perspective review elaborates on the recent advances in CRISPR‐Cas9 technology and its application as an innovative cancer treatment. Additionally, this perspective outlines
Md Mohiuddin, Md Al Mamun Ahsan
wiley   +1 more source

Origin of Neisseria meningitidis clonal complex 4821

Emerging Microbes and Infections
Neisseria meningitidis (N. meningitidis) is the causative agent of human invasive meningococcal disease (IMD). Clonal complex (CC) 4821 is a unique genetic cluster of N.
Zhizhou Tan, Lin Xu, Jie Che, Juan Xu, Li Xu, Hairui Wang, Maojun Zhang, Biao Kan, Jianguo Xu, Zhujun Shao   +9 more
doaj   +1 more source

Antimicrobial-Resistant Clonal Complex 11 Neisseria meningitidis–Associated Urethritis Cluster, Thailand

Emerging Infectious Diseases
Sexually transmitted infections clinics in Bangkok, Thailand, reported increasing numbers of men with Neisseria meningitidis–associated urethritis during 2017–2023.
John C. Cartee, Thitima Cherdtrakulkiat, Sandeep J. Joseph, Rossaphorn Kittiyaowamarn, Natnaree Girdthep, Pongsathorn Sangprasert, Porntip Paopang, Thidathip Wongsurawat, Piroon Jenjaroenpun, Perapon Nitayanon, Rebekah Frankson, Silvina Masciotra, Teodora Wi, Ismael Maatouk, Ellen N. Kersh, Andrey S. Borisov, Chanwit Tribuddharat   +16 more
doaj   +1 more source

Overwhelming Post‐Splenectomy Sepsis From Capnocytophaga canimorsus

International Journal of Laboratory Hematology, EarlyView.
Maitlyn Hsia, Maud Ahmad, Cyrus C. Hsia, Benjamin Chin‐Yee   +3 more
wiley   +1 more source

Untersuchung von Anti‐Glykan‐Antikörpern und Erforschung ihres medizinischen Potenzials mithilfe synthetischer Glykane

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

α-2,3-Sialyltransferase Expression Level Impacts the Kinetics of Lipooligosaccharide Sialylation, Complement Resistance, and the Ability of Neisseria gonorrhoeae to Colonize the Murine Genital Tract

mBio, 2015
Neisseria meningitidis and Neisseria gonorrhoeae modify the terminal lacto-N-neotetraose moiety of their lipooligosaccharide (LOS) with sialic acid. N.
Lisa A. Lewis, Sunita Gulati, Elizabeth Burrowes, Bo Zheng, Sanjay Ram, Peter A. Rice   +5 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent

Journal of Immunology Research, 2019
Meningococcal disease such as sepsis and meningitidis is hallmarked by an excessive inflammatory response. The causative agent, Neisseria meningitidis, expresses the endotoxin lipooligosaccharide (LOS) that is responsible for activation of immune cells ...
Berhane Asfaw Idosa, Anne Kelly, Susanne Jacobsson, Isak Demirel, Hans Fredlund, Eva Särndahl, Alexander Persson   +6 more
doaj   +1 more source