Results 61 to 70 of about 45,542 (259)

Safety and Effectiveness of Sutimlimab in Cold Agglutinin Disease: A Real‐World International Experience

American Journal of Hematology, EarlyView.
ABSTRACT Sutimlimab is a monoclonal antibody against complement fraction C1s approved for the treatment of hemolytic anemia due to cold agglutinin disease (CAD). Here, we analyzed and report the largest international CAD cohort of sutimlimab‐treated patients ever reported to highlight its safety and effectiveness in the real‐world setting. We accrued a
Bruno Fattizzo, Elisa Sambruna, Yoshitaka Miyakawa, Marc Michel, Carlo Visco, Michael Fillitz, George Kannourakis, Maria Bruna Greve, Moritz Kleemiss, Johan Cid, Andrea Patriarca, Laura Pavan, Arbana Dizdari, Nilla Maschio, Antonella Sau, Cinzia Bitetti, Riccardo Mario Colombo, Luigi Curreli, Dorela Lame, Uros Markovic, Fabrizio Pappagallo, Giacinto Luca Pedone, Davide Rapezzi, Vincenzo Sammartano, Nicola Tumedei, Antonio Giovanni Solimando, Jalink Marit, Luana Fianchi, Jahanzaib Khwaja, Antonio De Vivo, Francesco Lanza, Fabrizio Vianello, Esther N. Oliva, Catherine Broome, Francesco Passamonti, Ulrich Jaeger, Bernd Jilma, Guillaume Moulis, Wilma Barcellini   +38 more
wiley   +1 more source

Establishment of a PCR based method for detection of Neisseria meningitidis DNA: DUS as a marker for meningococcal carriage [PDF]

, 2016
Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de CoimbraNeisseria meningitidis is the main causative agent of meningitis and ...
Neves, Jessica Aguiar
core  

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis

Frontiers in Cellular and Infection Microbiology, 2022
Neisseria meningitidis is a gram-negative diplococcus and a transient commensal of the human nasopharynx. It shares and competes for this niche with a number of other Neisseria species including N. lactamica, N. cinerea and N. mucosa.
August Mikucki, Nicolie R. McCluskey, Nicolie R. McCluskey, Charlene M. Kahler   +3 more
doaj   +1 more source

Greater Cochlear Damage in Otogenic Versus Meningogenic Meningitis: Hearing Rehabilitation Implications

The Laryngoscope, EarlyView.
Otogenic route of meningitis was associated with greater cochlear hair cell loss in comparison with the meningogenic one in this otopathology study. Neuronal depletion has been traditionally implicated in failed hearing rehabilitation of post‐meningitis deafness.
Matheus Pedrosa Tavares, Henrique Furlan Pauna, Rafael da Costa Monsanto, Nevra Keskin‐Yilmaz, Breno Lima de Almeida, Norma de Oliveira Penido   +5 more
wiley   +1 more source

Genetic diversity of Neisseria meningitidis serogroup C ST-4821 in China based on multiple-locus variable number tandem repeat analysis. [PDF]

PLoS ONE, 2014
Neisseria meningitidis sequence type (ST)-4821 was first reported in China in 2003, and a new hyper-virulent lineage has been designated as the ST-4821 complex. A large number of N.
Xiaoying Shan, Ji Zhang, Haijian Zhou, Bingqing Zhu, Li Xu, Zhujun Shao, Baofa Jiang   +6 more
doaj   +1 more source

Parental Socio‐Economic Factors and the Risk of Invasive Bacterial Infections in Children: A Register‐Based Finnish Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Little is known about how socio‐economic factors influence severe childhood bacterial infections. We explored whether parental socio‐economic status correlates with the risk of invasive bacterial infections in the offspring. Methods Data on children < 16 years with community‐acquired blood or cerebrospinal fluid culture–positive bacterial ...
Kyrönlahti Anniina, Hermunen Teemu, Nieminen Tea, Koivisto Karoliina, Rantanen Matti, Saxén Harri, Madanat‐Harjuoja Laura   +6 more
wiley   +1 more source

Epidemiological characteristics of invasive meningococcal disease and carriage prevalence of Neisseria meningitidis in the Xinjiang Uygur Autonomous Region, China, 2004–2023: a retrospective study [PDF]

PeerJ
Objective The Xinjiang Uygur Autonomous Region (Xinjiang) currently exhibits the high incidence rates of invasive meningococcal disease (IMD) in China.
Halimubieke Nazhaerbieke, Wenhui Fu, Zhaoguo Lan, Yesitai Muheiyati, Tian Tian, Caipilima Wuqierjiafu, Na Xie   +6 more
doaj   +2 more sources

Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 Ȃ resolution [PDF]

, 2006
Copyright @ 2006 International Union of CrystallographyThe PII signal transduction proteins GlnB and GlnK are implicated in the regulation of nitrogen assimilation in Escherichia coli and other enteric bacteria.
Alderton, D, Berrow, NS, Nichols, CE, Owens, RJ, Sainsbury, S, Saunders, NJ, Stammers, DK   +6 more
core   +1 more source

Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cells. [PDF]

PLoS Pathogens, 2014
The interaction with brain endothelial cells is central to the pathogenicity of Neisseria meningitidis infections. Here, we show that N. meningitidis causes transient activation of acid sphingomyelinase (ASM) followed by ceramide release in brain ...
Alexander Simonis, Sabrina Hebling, Erich Gulbins, Sibylle Schneider-Schaulies, Alexandra Schubert-Unkmeir   +4 more
doaj   +1 more source