Results 71 to 80 of about 45,542 (259)

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo. [PDF]

, 2014
Spores of some species of the strictly anaerobic bacteria Clostridium naturally target and partially lyse the hypoxic cores of tumors, which tend to be refractory to conventional therapies. The anti-tumor effect can be augmented by engineering strains to
Dubois, L, Ehsaan, M, Heap, JT, Knox, R, Kubiak, AM, Kuehne, SA, Lambin, P, Mellaert, LV, Minton, NP, Paesmans, K, Theys, J   +10 more
core   +4 more sources

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Genetic characterization of Neisseria meningitidis isolates recovered from patients with invasive meningococcal disease in Lithuania

Frontiers in Cellular and Infection Microbiology
IntroductionNeisseria meningitidis is a gram-negative bacterium responsible for life-threatening invasive infections known as invasive meningococcal disease and is associated with high fatality rates and serious lifelong disabilities among survivors ...
Anželika Slavinska, Magdalena Kowalczyk, Agnė Kirkliauskienė, Greta Vizuje, Paweł Siedlecki, Joana Bikulčienė, Kristina Tamošiūnienė, Aurelija Petrutienė, Nomeda Kuisiene   +8 more
doaj   +1 more source

Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation

mSphere, 2019
Neisseria meningitidis is an inhabitant of the nasopharynx, from which it is transmitted from person to person or disseminates in blood and becomes a harmful pathogen. In this work, we addressed colonization of the nasopharyngeal niche by focusing on the
Mathilde Audry, Catherine Robbe-Masselot, Jean-Philippe Barnier, Benoit Gachet, Bruno Saubaméa, Alain Schmitt, Sophia Schönherr-Hellec, Renaud Léonard, Xavier Nassif, Mathieu Coureuil   +9 more
doaj   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Quantification of Neisseria meningitidis Adherence to Human Epithelial Cells by Colony Counting

Bio-Protocol, 2018
To cause an infection, the human specific pathogen Neisseria meningitides must first colonize the nasopharynx. Upon tight interaction with the mucosal epithelium, N.
Sara Sigurlásdóttir, Sunil Saroj, Olaspers Eriksson, Jens Eriksson, Ann-Beth Jonsson   +4 more
doaj   +1 more source

Identification and characterization of pptA: a gene involved in the phase-variable expression of phosphorylcholine on pili of Neisseria meningitidis [PDF]

, 2003
Pili of pathogenic Neisseria are major virulence factors associated with adhesion, cytotoxicity, twitching motility, autoaggregation, and DNA transformation. Pili are modified posttranslationally by the addition of phosphorylcholine.
Warren, Matthew J., Jennings, Michael P.
core   +1 more source

[Neuraminidase activity of N. meningitidis].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1976
The work was aimed at the study of the neuraminidase activity of meningococci. The optimal conditions for detection of this enzyme in meningococci were chosen preliminarily. In experiments carried out with the observance of these conditions it was shown that meningococci of the main serological groups possessed neuraminidase activity revealed in the ...
G V, Zhuravleva, A A, Demina, A M, Gracheva   +2 more
openaire   +1 more source

Serious Bacterial Infections in Hospitalized Neonates in Eastern Ethiopia: Investigating the Emerging Pathogen Pantoea dispersa Compared With Klebsiella pneumoniae

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Serious bacterial infections (SBIs) are major contributors to neonatal morbidity and mortality in low‐income countries. We describe the aetiology and risk factors for neonatal bacteraemia and in‐hospital mortality in eastern Ethiopia, focusing on Pantoea dispersa, a rarely studied pathogen, and Klebsiella pneumoniae.
Yunus Edris, Faisel A. Hassen, Desalegn A. Ayana, Fami Ahmed, Haleluya Leulseged, Dadi Marami, Jabir Aliye, Belete G. Alem, Zelalem T. Mariam, Gezahang Mengesha, Nega Assefa, Alexander M. Aiken, J. Anthony G. Scott, Lola Madrid   +13 more
wiley   +1 more source

Symptomatic Vaginal Infection by Neisseria meningitidis Resulting in Meningitis with Septic Shock

Clinical Practice and Cases in Emergency Medicine, 2019
The most common infectious etiologies of vaginitis include Gardnerella bacterial vaginosis, candidiasis, and trichomoniasis. A few case reports describe symptomatic infection with Neisseria (N) meningitidis, an organism with potential for causing ...
Ryan Offman, Elissa Boggs, Adam Gwizdala
doaj   +1 more source