Results 101 to 110 of about 28,700 (263)

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

Nature Communications, 2019
Erythropoiesis can be regulated by transcriptional, epigenetic, and post-transcriptional mechanisms. Here the authors report that N6-methyladenosine mRNA methyltransferase complex stimulates erythropoiesis by promoting translation of specific mRNAs.
Daniel A. Kuppers, Sonali Arora, Yiting Lim, Andrea R. Lim, Lucas M. Carter, Philip D. Corrin, Christopher L. Plaisier, Ryan Basom, Jeffrey J. Delrow, Shiyan Wang, Housheng Hansen He, Beverly Torok-Storb, Andrew C. Hsieh, Patrick J. Paddison   +13 more
doaj   +1 more source

Data_Sheet_11_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.ZIP

, 2021
Jingchao Liu (2051245), Jianlong Wang (438075), Meng Wu (191457), Wei Zhang (405), Lingfeng Meng (2576632), Jiawen Wang (350508), Zhengtong Lv (10146227), Haoran Xia (7062632), Yaoguang Zhang (746651), Jianye Wang (453856)   +9 more
openalex   +2 more sources

N6-methyladenosine (m6A) RNA modification as a metabolic switch between plant cell survival and death in leaf senescence [PDF]

, 2023
Elżbieta Rudy, Magda Grabsztunowicz, Magdalena Arasimowicz‐Jelonek, Umesh Kumar Tanwar, Julia Maciorowska, Ewa Sobieszczuk‐Nowicka   +5 more
openalex   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Placental RTN3L‐dependent ER‐Phagy Contributes to Fetal Testicular Dysplasia Upon Environmental Stress

Advanced Science
Prenatal environmental stress damages fetal testicular development, leading to male infertility. However, the precise mechanisms underlying the impact of gestational environmental stress on fetal testicular development require further investigation. This
Ye‐Xin Luo, Hua‐Long Zhu, Bin‐Bin Huang, Cheng‐Fang Sun, Xin‐Xin Zhang, Xin‐Run Wang, Yi‐Fan Hu, Xu‐Dong Zhang, Shen‐Dong Xu, Huan Zhou, Rui Pan, Wei Chang, Zhi Yuan, Yong‐Wei Xiong, Xiao‐Feng Xu, Ling‐Li Zhao, De‐Xiang Xu, Hua Wang   +17 more
doaj   +1 more source

From form to function: m6A methylation links mRNA structure to metabolism [PDF]

, 2022
Reversible N6-methyladenosine (m6A) RNA modification is a posttranscriptional epigenetic modification of the RNA that regulates many key aspects of RNA metabolism and function. In this review, we highlight major recent advances in the field, with special
Darsinou, Marousa, Martinez De La Cruz, Braulio, Riccio, Antonella   +2 more
core  

Ibuprofen promotes p75 neurotrophin receptor expression through modifying promoter methylation and N6-methyladenosine-RNA-methylation in human gastric cancer cells [PDF]

, 2022
Haifeng Jin, Zheng Wu, Bi-Bo Tan, Zhen Liu, Zhanfei Zu, Xiaoyun Wu, Yuwang Bi, Xingmao Hu   +7 more
openalex   +1 more source

RBM15 Mediated m6A Modification of SRSF1 Inhibits Cuproptosis in Non‐Small Cell Lung Cancer by Mediating ATP7B Alternative Splicing

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Inhibition of cuproptosis contributes to the development of non‐small cell lung cancer (NSCLC). The expression of RNA‐binding motif protein 15 (RBM15) is upregulated in NSCLC. Nonetheless, its relationship with cuproptosis remains unclear. This study aimed to explore the role of RBM15 in regulating cuproptosis in NSCLC. A549 cells were treated
Shan‐shan Mao, Dong‐yu Wu, Rong‐hua Cui, Xiao‐zhen Cheng   +3 more
wiley   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source

N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development

Acta Pharmaceutica Sinica B, 2018
N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Yi Niu, Arabella Wan, Ziyou Lin, Xiongbin Lu, Guohui Wan   +4 more
doaj   +1 more source