Results 101 to 110 of about 17,313 (241)

The m6A demethylase FTO promotes C/EBPβ‐LIP translation to perform oncogenic functions in breast cancer cells

The FEBS Journal, EarlyView.
N6‐methyladenosine is a key mRNA modification that regulates transcript turnover, translation, and other aspects of RNA fate. The m6A‐demethylase ‘eraser’ enzyme FTO reverses this modification. While FTO is known to promote oncogenic signaling in triple‐negative breast cancer, its wider role across the genome and specific downstream signaling has yet ...
Hidde R. Zuidhof, Christine Müller, Gertrud Kortman, René Wardenaar, Ekaterina Stepanova, Fabricio Loayza‐Puch, Cornelis F. Calkhoven   +6 more
wiley   +1 more source

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

Molecular Therapy: Nucleic Acids, 2020
N6-Methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) that occurred on the N6 nitrogen of adenosine. However, the roles of m6A in oral squamous cell carcinoma (OSCC) are still elusive.
Wei Zhao, Yameng Cui, Lina Liu, Xiaozhou Ma, Xiaoqian Qi, Yue Wang, Zihao Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +9 more
doaj  

The N6‐methyladenosine reader IGF2BP3 promotes bladder cancer progression through enhancing HSP90AB1 expression

The FEBS Journal, EarlyView.
N6‐methyladenosine (m6A) is a frequently occurring RNA modification that has emerged as an important player in tumour development through post‐transcriptional gene regulation. In this study, we found that IGF2BP3 modulates HSP90AB1 expression in an m6A modification‐dependent manner, activating the PI3K/AKT‐signaling pathway, and thereby promoting the ...
Xiaoqing Chen, Wenli Diao, Xinyue Guo, Wenmin Cao, Yang Yang, Tianlei Xie, Wei Chen, Lin Yang, Qing Zhang, Meng Ding, Hongqian Guo   +10 more
wiley   +1 more source

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells [PDF]

, 2017
Ly Vu, Brian F. Pickering, Yuanming Cheng, Sara Zaccara, Diu Nguyen, Gerard Minuesa, Timothy Chou, Arthur Chow, Yogesh Saletore, Matthew MacKay, Jessica Schulman, Christopher Famulare, Minal Patel, Virginia M. Klimek, Francine E. Garrett-Bakelman, Ari Melnick, Martin Carroll, Christopher E. Mason, Samie R. Jaffrey, Michael G. Kharas   +19 more
openalex   +1 more source

Emerging Orchestrator of Ecological Adaptation: m6A Regulation of Post‐Transcriptional Mechanisms

Molecular Ecology, EarlyView.
ABSTRACT Genetic mechanisms have been at the forefront of our exploration into the substrate of adaptive evolution and phenotypic diversification. However, genetic variation only accounts for a fraction of phenotypic variation. In the last decade, the significance of RNA modification mechanisms has become more apparent in the context of organismal ...
Ehsan Pashay Ahi, Pooja Singh
wiley   +1 more source

Molecular Simulations Matching Denaturation Experiments for N6‑Methyladenosine

ACS Central Science, 2022
Valerio Piomponi, Thorben Fröhlking, Mattia Bernetti, Giovanni Bussi   +3 more
doaj   +1 more source

N6-Methyladenosine in RNA and DNA: An Epitranscriptomic and Epigenetic Player Implicated in Determination of Stem Cell Fate [PDF]

, 2018
Pengfei Ji, Xia Wang, Nina Xie, Yujing Li   +3 more
openalex   +1 more source

Salt Stress Adaptations in Soybean Involve Alterations in Pre‐mRNA Processing

Plant, Cell &Environment, EarlyView.
ABSTRACT Salt stress can seriously affect plant survival. To adapt to salt stress, plants can alter gene expressions and/or pre‐mRNA processing patterns, or both. Previous studies could not comprehensively profile stress‐responsive pre‐mRNA processing patterns due to limitations in traditional sequencing technologies.
Shoudong Zhang, Zhixia Xiao, Ailin Liu, Dongpeng Ren, Shengjie Chen, Hanxue Zhang, Li Zhang, Zhili Wang, Jun Yang, Hon‐Ming Lam   +9 more
wiley   +1 more source

REPIC: a database for exploring the N6-methyladenosine methylome [PDF]

, 2020
Shun Liu, Allen Zhu, Chuan He, Mengjie Chen   +3 more
openalex   +1 more source

YTHDF3 promotes melanoma metastasis by reading N6‐methyladenosine

Clinical and Translational Discovery, 2022
Ivan Yu Cheng, Chun‐Ming Wong
doaj   +1 more source