Results 41 to 50 of about 17,313 (241)

Role of N6-methyladenosine modification in cancer

Current Opinion in Genetics & Development, 2018
As the most abundant internal modification in eukaryotic messenger RNAs identified, N6-methyladenosine (m6A) has been shown recently to play essential roles in various normal bioprocesses. Evidence is emerging that m6A modification and its regulatory proteins also play critical roles in various cancers including leukemia, brain tumor, breast cancer and
Rui Su, Jianjun Chen, Jianjun Chen, Xiaolan Deng, Xiaolan Deng, Xiaolan Deng, Xuesong Feng, Minjie Wei   +7 more
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N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses [PDF]

Frontiers in Cell and Developmental Biology, 2021
N6-methyladenosine (m6A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m6A modification is connected with diseases caused by pathogenic viruses, and studies on the role of m6A in virus-host interactions have ...
Qianyu Feng, Qianyu Feng, Hongwei Zhao, Hongwei Zhao, Lili Xu, Lili Xu, Zhengde Xie, Zhengde Xie   +7 more
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FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Nature Communications, 2021
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David   +21 more
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The importance of N6-methyladenosine modification in tumor immunity and immunotherapy

Experimental Hematology & Oncology, 2022
As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor.
Ze Zhang, Furong Liu, Wei Chen, Zhibin Liao, Wanguang Zhang, Bixiang Zhang, Huifang Liang, Liang Chu, Zhanguo Zhang   +8 more
doaj   +1 more source

N6-Methyladenosine-Sculpted Regulatory Landscape of Noncoding RNA [PDF]

Frontiers in Oncology, 2021
The exploration of dynamic N6-methyladenosine (m6A) RNA modification in mammalian cells has attracted great interest in recent years. M6A modification plays pivotal roles in multiple biological and pathological processes, including cellular reprogramming, fertility, senescence, and tumorigenesis.
Wei Wei, Zhong-Yuan Zhang, Jiang-Ning Dong, Hao Wang   +3 more
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EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle

Frontiers in Microbiology, 2022
N6-methyladenosine (m6A) mediates various biological processes by affecting RNA stability, splicing, and translational efficiency. The roles of m6A modification in Epstein-Barr virus (EBV) infection in the lytic phase are unclear.
Yusuke Yanagi, Takahiro Watanabe, Yuya Hara, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata, Takayuki Murata   +6 more
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The role of N6-methyladenosine (m6A) in kidney diseases

Frontiers in Medicine, 2023
Chemical modifications are a specific and efficient way to regulate the function of biological macromolecules. Among them, RNA molecules exhibit a variety of modifications that play important regulatory roles in various biological processes. More than 170 modifications have been identified in RNA molecules, among which the most common internal ...
Luling You, Zhongyu Han, Haoran Chen, Liuyan Chen, Yumeng Lin, Binjian Wang, Yiyue Fan, Meiqi Zhang, Ji Luo, Fang Peng, Yue Ma, Yanmei Wang, Lan Yuan, Zhongyu Han   +13 more
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Research Progress of N6-Methyladenosine in the Cardiovascular System

Medical Science Monitor, 2020
According to the World Health Organization cardiovascular disease risk charts, the mortality rate of cardiovascular diseases in people is still high. The medical expenses caused by cardiovascular diseases are increasing daily, and the medical burden is becoming heavier; as such, it is imperative to prevent and cure cardiovascular diseases.
Haochang Hu, Nan Zheng, Jingqiao Wang, Xiaomin Chen, Jia Su   +4 more
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Potential roles of N6-methyladenosine (m6A) in immune cells [PDF]

Journal of Translational Medicine, 2021
AbstractN6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human diseases. Therefore, m6A modification has become a research hotspot for its potential therapeutic applications in the treatment of various ...
Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng, Biao Wang   +8 more
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RNA N6-methyladenosine methylation and skin diseases

Autoimmunity, 2023
Skin diseases are global health issues caused by multiple pathogenic factors, in which epigenetics plays an invaluable role. Post-transcriptional RNA modifications are important epigenetic mechanism that regulate gene expression at the genome-wide level. N6-methyladenosine (m6A) is the most prevalent modification that occurs in the messenger RNAs (mRNA)
Yaqin Yu, Shuang Lu, Hui Jin, Huan Zhu, Xingyu Wei, Tian Zhou, Ming Zhao   +6 more
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