Results 71 to 80 of about 28,700 (263)
Advanced Science, EarlyView.Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang +9 more
wiley +1 more source
Role of N6‐methyladenosine RNA modification in cancer
MedCommN6‐methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells. Previous studies have shown that m6A is pivotal in diverse diseases especially cancer.
Yi Qu +10 more
doaj +1 more source
Ythdc1‐p300‐Klf5 Complex‐Mediated Golgi Dysfunction Promotes Aortic Aneurysm
Advanced Science, EarlyView.In their Research Article (DOI: https://doi.org/10.1002/advs.202512116* lF: 14.1 Q1), Wenli Wang and co‐workers identifies a novel lncRNA m6A modification‐dependent regulatory mechanism of vascular homeostasis, and constructs a predictive model for post‐operative short‐term death based on AD patient's features, providing a platform to be able to ...
Wen‐Li Wang +22 more
wiley +1 more source
The crosstalk between N6‐methyladenosine readers and neuroblastoma
Clinical and Translational DiscoveryBackground Neuroblastoma (NB) is a heterogeneous pediatric solid tumour strongly influenced by epigenetic modifications. Methods This review explores the role of N6‐methyladenosine (m6A) modifications and their readers in NB progression.
Liping Chen, Jing He, Zhenjian Zhuo
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Neural Regeneration ResearchThe neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury. The post-transcriptional modification of N6-methyladenosine is ubiquitous in the immune response of the ...
Xiangrong Chen +6 more
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tRNA Thiolation Links Translation to Stress Responses in Saccharomyces cerevisiae [PDF]
, 2014 Although tRNA modifications have been well catalogued, the precise functions of many modifications and their roles in mediating gene expression are still being elucidated.
Damon, Jadyn Rose +2 more
core +1 more source
Advanced Science, EarlyView.This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan +12 more
wiley +1 more source
RNA N6‐methyladenosine connects YTHDF3 and LOXL3 to promote melanoma metastasis
Clinical and Translational Discovery, 2022 N6‐methyladenosine (m6A) modifications of RNAs are associated with diverse biological processes in normal and cancer cells. In melanoma cancers, mutations in genes that function in the writing or erasure of RNA m6A have been shown to affect cancer ...
Mamta B Nirmal, Tommy V. Vo
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Advanced Science, EarlyView.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
The biological function of demethylase ALKBH1 and its role in human diseases
HeliyonAlkB homolog 1 (ALKBH1) is a member of the AlkB family of dioxygenases that are dependent on Fe(II) and α-ketoglutarate. Mounting evidence demonstrates that ALKBH1 exhibits enzymatic activity against various substrates, including N6-methyladenosine (m6A),
Jing Zhong +4 more
doaj +1 more source