Results 71 to 80 of about 17,313 (241)

Liver-specific Mettl3 ablation delays liver regeneration in mice

Genes and Diseases, 2022
This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration following partial hepatectomy in mice. We created a liver-specific knockout mouse model by the deletion of Mettl3, a key component of the N6-methyladenosine ...
Jiaxiang Meng, Zhicong Zhao, Zhifeng Xi, Qiang Xia   +3 more
doaj  

N6‐methyladenosine reader YTHDF3 regulates melanoma metastasis via its ‘executor' LOXL3

Clinical and Translational Medicine, 2022
Background A number of studies have demonstrated that N6‐methyladenosine (m6A) plays a vital role in the pathological process of various tumours. Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma.
Hao‐ze Shi, Jing‐shu Xiong, Lu Gan, Ying Zhang, Cong‐cong Zhang, Ying‐qi Kong, Qiu‐ju Miao, Cui‐cui Tian, Rong Li, Jin‐quan Liu, Er‐jia Zhang, Wen‐bo Bu, Yan Wang, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +15 more
doaj   +1 more source

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD‐1 Blockade in MSS Colorectal Cancer

Advanced Science, EarlyView.
xxxx. Abstract Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored.
Qi‐Long Wang, Zijie Chen, Xiaofei Lu, Huizhen Lin, Huolun Feng, Nuozhou Weng, Liwen Chen, Mengnan Liu, Li Long, Lingjun Huang, Yongmei Deng, Kehong Zheng, Xiaojun Zheng, Yong Li, Ting Cai, Jiabin Zheng, Wei Yang   +16 more
wiley   +1 more source

m6A‐mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly

Autism Research, EarlyView.
ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD‐DM) seen at three years of age is associated with co‐occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD‐DM have yet to be delineated. In this study, we identified additional ASD‐DM candidate genes
Sierra S. Nishizaki, Nicholas K. Haghani, Gabriana N. La, Natasha Ann F. Mariano, José M. Uribe‐Salazar, Gulhan Kaya, Melissa Regester, Derek Sayre Andrews, Christine Wu Nordahl, David G. Amaral, Megan Y. Dennis   +10 more
wiley   +1 more source

scm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development

Nature Communications, 2023
Modification of RNA with N6-methyladenosine can regulate RNA metabolism. Here they developed scm6A-seq to profile the methylome and transcriptome in single cells, and reveal the functions of m6A modification during oocyte maturation and early embryo ...
Huan Yao, Chun-Chun Gao, Danru Zhang, Jiawei Xu, Gege Song, Xiu Fan, Dao-Bo Liang, Yu-Sheng Chen, Qian Li, Yanjie Guo, Yu-Ting Cai, Lulu Hu, Yong-Liang Zhao, Ying-Pu Sun, Ying Yang, Jianyong Han, Yun-Gui Yang   +16 more
doaj   +1 more source

Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a “hit‐and‐run” paradigm

Cancer Communications, EarlyView.
Abstract Background Helicobacter pylori (H. pylori) infection contributes significantly to gastric cancer (GC) progression. The intrinsic mechanisms of H. pylori‐host interactions and their role in promoting GC progression need further investigation.
Bing He, Yiyang Hu, Yuyun Wu, Chao Wang, Limin Gao, Chunli Gong, Zhibin Li, Nannan Gao, Huan Yang, Yufeng Xiao, Shiming Yang   +10 more
wiley   +1 more source

A neural m6A/Ythdf pathway is required for learning and memory in Drosophila

Nature Communications, 2021
Epitranscriptomic modifications can regulate learning and memory. Here, the authors provide proteomic and functional analysis of N6-methyladenosine (m6A)-binding proteins in D.
Lijuan Kan, Stanislav Ott, Brian Joseph, Eun Sil Park, Wei Dai, Ralph E. Kleiner, Adam Claridge-Chang, Eric C. Lai   +7 more
doaj   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

N 6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice

Nature Communications, 2023
N6-methyladenosine (m6A) methylation of RNA is a common type of RNA modification that regulates gene expression. Here, the authors report m6A methylation of serpin 2 A negatively regulates inflammation and reduces heart dysfunction in the setting of ...
Xiangyu Wang, Yan Ding, Ran Li, Rujun Zhang, Xuejun Ge, Ruifang Gao, Miao Wang, Yubing Huang, Fang Zhang, Bin Zhao, Wang Liao, Jie Du   +11 more
doaj   +1 more source

FLOT1 Is a Novel Serum Biomarker of Ovarian Cancer Targeted by N6‐methyladenosine Modification Inhibition

Cell Biology International, EarlyView.
ABSTRACT Ovarian cancer (OC) is a deadly disease and lacks a precise marker for diagnosis worldwide. Our previous work has shown the overexpression of flotillin‐1 (FLOT1) in OC tissue. To improve diagnostic sensitivity and accuracy, we evaluated the serum level of FLOT1 in OC patients and found that the serum concentration of FLOT1 as well as CA125 was
Bin Guan, Qi Lu, Junyu Chen, Jingyi Fang, Zhenyu Liu, Wei Li, Lingyun Zhang, Guoxiong Xu   +7 more
wiley   +1 more source