Results 121 to 130 of about 22,540 (229)
The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
Frontiers in Cell and Developmental Biology, 2020 N6-methyladenosine (m6A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M6A can be catalyzed by m6A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO ...
Yang Li +5 more
doaj +1 more source
RNA Methylation and Ythdf Readers in Posttranscriptional Regulation and Development [PDF]
, 2021 Development in animals requires precise and coordinated changes in gene expression. This genetic remodeling is achieved through extensive regulatory networks of proteins and RNAs that function together to specify new cell fates and patterns.
Kontur, Cassandra
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu +5 more
wiley +1 more source
Role of N6-Methyladenosine (m6A) RNA Modification in Multiple Myeloma
Blood, 2018 Abstract Multiple myeloma (MM) is considered a chronic and incurable disease due to its highly complex and heterogeneous molecular abnormalities. In recent years, integrating proteasome inhibitors and immunomodulatory drugs into MM frontline therapy has significantly improved treatment efficacy with a median overall survival (OS) being ...
Christian Bach +6 more
openaire +1 more source
m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2
Genomics, Proteomics & Bioinformatics, 2019 N6-methyladenosine (m6A), catalyzed by the methyltransferase complex consisting of Mettl3 and Mettl14, is the most abundant RNA modification in mRNAs and participates in diverse biological processes.
Junchen Chen +10 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source
m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
Nature Communications, 2019 Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example ...
G. Guy Bushkin +7 more
doaj +1 more source
Epitranscriptomic code and its alterations in human disease [PDF]
, 2018 Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modifications to date. These developments, together with the recent discovery of writers, readers, and erasers of modifications occurring across a wide range of ...
Janga, Sarath Chandra +1 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ischemic reperfusion injury (IRI) to kidney is a significant clinical factor in acute kidney injury (AKI). This study aimed to investigate the new role of RNA‐binding motif protein X‐linked (RBMX), a modulator of m6A methylation, in renal IRI and to examine the associated regulatory mechanisms. An in vitro renal IRI model was established using
Yi‐Han Wang +4 more
wiley +1 more source
The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome [PDF]
Chronic hepatitis B is a global health problem and current treatments only suppress hepatitis B virus (HBV) infection, highlighting the need for new curative treatments.
Balfe, Peter +6 more
core +2 more sources