Amino Acid Metabolism in Health and Disease
MedComm, Volume 7, Issue 9, September 2026.This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su +7 more
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Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances
MedComm, Volume 7, Issue 9, September 2026.The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong +5 more
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RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
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N6-methyladenosine (m6A) methylation in adipose tissue: role, regulation, and therapeutic potential. [PDF]
Cell Mol Life SciLiu Q, Peng WQ, Guo L.
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MedComm, Volume 7, Issue 9, September 2026.In psoriasis, METTL7A is upregulated in aged CXCR4hi neutrophils, where it stabilizes PLSCR1 mRNA via m6A modification to enhance reactive oxygen species (ROS) production and neutrophil extracellular trap (NET) formation, thereby exacerbating disease severity.
Wanting Liu +15 more
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Mechanism of N6-methyladenosine (m6A)-mediated upregulation of LINC00958 in the growth of cervical cancer. [PDF]
Front OncolLi Y, Liu Z, Jin H.
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N6-methyladenosine (m6A) modification in osteosarcoma: expression, function and interaction with noncoding RNAs - an updated review. [PDF]
Epigenetics, 2023 Zhang Y +9 more
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MedComm, Volume 7, Issue 9, September 2026.METTL14‐mediated N6‐methyladenosine aggravates ischemia/reperfusion‐induced acute lung injury by enhancing YTHDF1‐dependent USP30 expression. USP30 stabilizes NCOA4 through deubiquitination, thereby promoting ferritinophagy, iron accumulation, lipid peroxidation, and ferroptosis in lung epithelial cells.
Aming Sang +8 more
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N6-methyladenosine (m6A) post-transcriptional modification regulation of mRNA, an overlooked therapeutic opportunity to leverage mRNA processing in vascular smooth muscle cells. [PDF]
Vascul PharmacolOpenko D, Autieri MV.
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Oral Science International, Volume 23, Issue 3, September 2026.ABSTRACT N6‐methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic RNA and a central mechanism of epitranscriptomic gene regulation. Although m6A was first characterized in messenger RNA (mRNA), it is also deposited on ribosomal RNA (rRNA), circular RNA, and other RNA species, where it regulates RNA stability, decay ...
Shoichiro Kokabu, Quan Yuan
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