Results 151 to 160 of about 17,129 (229)

N6‐Methyladenosine Demethylase FTO Mitigates Cerebral Ischemia–Reperfusion Injury by Suppressing AQP4 Expression

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Mechanism of FTO regulating Hspa1a m6A modification for protection against CIRI. A CIRI leads to a decrease in FTO expression in astrocytes followed by an increase in Hspa1a m6A modification, which promotes HSPA1A degradation. Simultaneously, the NF‐κB pathway becomes activated, and AQP4 expression is upregulated.
Wei Chen, Luyuan Cao, Xiaoxiao Zheng, Chenyuan Yu, Xiaoqiang Zhu, Qing Wang, Li Zheng, Jiahua Lan, Cheng Jiang, Hongwei Wang   +9 more
wiley   +1 more source

Comprehensive Genome-Wide Identification and Expression Analysis of the N6-Methyladenosine (m6A) Regulatory Network Influences Rapid Stress Adaptation With Exogenous Melatonin in Rice. [PDF]

J Pineal Res
Khanzada H, Wassan GM, Wang P, Khanzada S, Wang X, Xia Z.   +5 more
europepmc   +1 more source

Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance. [PDF]

Clin Epigenetics, 2023
Yu R, Yu Q, Li Z, Li J, Yang J, Hu Y, Zheng N, Li X, Song Y, Li J, Chen X, Du W, Su J.   +12 more
europepmc   +1 more source

Bard1‐Mediated Regulation of Hnrnpa2b1 Ubiquitination and Protein Stability Contributes to Neuronal Ferroptosis and Cognitive Dysfunction Following Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Bard1‐mediated ubiquitination of Hnrnpa2b1 in mice with PSCI destabilizes Sptbn2, which prevents the membrane translocation of Slc7a11 and reduces cystine uptake. This disruption of antioxidant defense triggers ferroptosis in hippocampal neurons, highlighting a novel molecular pathway linking post‐stroke cognitive impairment to ferroptosis of ...
Tuming Li, Tianyi Rong, Zuoting Shen, Zhenyu Wei, Deyan Chen, Ping Zhong, Li Cao   +6 more
wiley   +1 more source

Role of N6-Methyladenosine (m6A) epitranscriptomic mark in regulating viral infections and target for antiviral development. [PDF]

Front Pharmacol
Bayoumi M, Manju V, Martinez-Sobrido L, Munir M.   +3 more
europepmc   +1 more source

ZC3H13‐mediated m6A stabilization of CCND1 promotes malignant progression and is associated with poor anti‐PD‐1 response in HNSCC

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ZC3H13 promotes HNSCC progression and anti‐PD‐1 resistance by enhancing IGF2BP1‐mediated stabilization of CCND1 mRNA in an m6A‐dependent manner. Targeting ZC3H13 suppresses oral tumorigenesis and improves response to PD‐1 blockade. Abstract Background Resistance to immune checkpoint blockade substantially limits its clinical efficacy in head and neck ...
Wenqing Chen, Yun Li, Shuang Chen, Caihua Zhang, Zhi Liu, Kai Sun, Yingyi Li, Chunlong Yang, Wenbin Lei, Kang Li   +9 more
wiley   +1 more source

Functional effects of heavy metal exposures on N6-methyladenosine (m6A) methylation and other Epitranscriptomic modifications in the central nervous system. [PDF]

Neurochem Int
Lodhi N, Powell L, Schneider JS.
europepmc   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

m6A‐methylated circFANCB Promotes Gastric Cancer Progression by Regulating Cellular Ferroptosis Through miR‐454‐3p/CEACAM5

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This study reveals that METTL3 regulates circFANCB expression by inducing m6A modification. CircFANCB modulates cellular ferroptosis by regulating the miR‐454‐3p/CEACAM5 axis, thereby promoting the growth and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) is a major global digestive malignancy with high incidence and mortality ...
Haifeng Wang, Yan Li, Tiantian Sun, Man Su, Wei Dai, Zhihui Jin, Hangchen Shen, Changyu Jin, Yan Gao   +8 more
wiley   +1 more source

PCAT6 Regulates IGF2BP1/PD‐L1 to Promote Immune Escape in Breast Cancer

The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.
The lncRNA PCAT6 is upregulated in triple‐negative breast cancer (TNBC) and correlates with aggressive tumor features. Mechanistically, PCAT6 interacts with the RNA‐binding protein IGF2BP1 in the cytoplasm, enhancing IGF2BP1‐mediated stabilization of PD‐L1 mRNA and consequently upregulating PD‐L1 expression on tumor cells. Elevated PD‐L1 suppresses CD8+
Dingping Sun, Shanglong Sun, Jing Li, Liping Gu, Weijian Yang, Li Shang   +5 more
wiley   +1 more source