Results 171 to 180 of about 54,300 (231)

Retracted: The N6-Methyladenosine- (m6A-) Associated Genes Act as Strong Key Biomarkers for the Prognosis of Pancreatic Adenocarcinoma. [PDF]

Comput Math Methods Med, 2023
Methods In Medicine CAM.
europepmc   +1 more source

DNMT1 Regulates Testosterone Synthesis in Aged Rat Leydig Cells via FTO‐Mediated HSP90AA1 m6A Levels

Aging Cell, Volume 25, Issue 10, October 2026.
During Leydig cell senescence, decreased DNMT1 triggers Fto promoter hypomethylation and upregulates FTO. Elevated FTO reduces m6A modification of Hsp90aa1, lowering HSP90AA1 to inhibit AKT signaling, facilitate apoptosis and reduce testosterone synthesis.
Yaqi Li, Yulei Duan, Zihang Tian, Yibing Gao, Yufei Qiao, Shuang Zhao, Wenyan Li, Zheng Gao, Siyun Niu   +8 more
wiley   +1 more source

N6-methyladenosine (m6A) dysregulation contributes to network excitability in temporal lobe epilepsy. [PDF]

JCI Insight
Mathoux J, Wilson MM, Srinivas S, Litovskich G, Villalba Benito L, Tran C, Kesavan J, Harnett A, Auer T, Sanz-Rodriguez A, Kh A E Alkhayyat M, Sullivan M, Liu Z, Huang Y, Lacey A, Delanty N, Cryan J, Brett FM, Farrell MA, O'Brien DF, Casillas-Espinosa PM, Jimenez-Mateos EM, Glennon JC, Canavan M, Henshall DC, Brennan GP.   +25 more
europepmc   +1 more source

METTL14‐Mediated m6A Methylation Preserves Cardiomyocyte Homeostasis and Attenuates Progeria‐Associated Cardiac Remodeling

Aging Cell, Volume 25, Issue 10, October 2026.
Progerin accumulation downregulates the expression of m6A methyltransferases METTL3 and METTL14 in cardiac tissues, impairing m6A modification‐mediated regulation of target genes including Casq2, Ifna and Ifnb, leading to calcium signaling dysregulation and pro‐inflammatory activation in the aged heart.
Shixiao Wang, Jie Zhang, Ying Ao, Dan Rao, Cong Yu, Chenzhong Xu, Ming Wang, Mingying Li, Xin Huang, Jianfei Zhang, Rui Mei, Zhen Zhang, Jie Sun, Juanli Duan, Ying Sun, Zimei Wang, Wen Su, Baohua Liu   +17 more
wiley   +1 more source

Comprehensive Genome-Wide Identification and Expression Analysis of the N6-Methyladenosine (m6A) Regulatory Network Influences Rapid Stress Adaptation With Exogenous Melatonin in Rice. [PDF]

J Pineal Res
Khanzada H, Wassan GM, Wang P, Khanzada S, Wang X, Xia Z.   +5 more
europepmc   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Cancer Science, Volume 117, Issue 10, Page 2733-2751, October 2026.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang, Tianli Zhang, Xue Kong, Yao Tong, Yanru Li, Xiangjun Dong, Chuanxin Wang, Juan Li   +7 more
wiley   +1 more source

Role of N6-Methyladenosine (m6A) epitranscriptomic mark in regulating viral infections and target for antiviral development. [PDF]

Front Pharmacol
Bayoumi M, Manju V, Martinez-Sobrido L, Munir M.   +3 more
europepmc   +1 more source

N6‐Methyladenosine Demethylase FTO Protects Pancreatic ΒTC6 Cells From Cholesterol‐Triggered Damage by Regulating Nfatc4: Insights From RNA‐Seq Analysis

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
FTO Protects Mouse Pancreatic Beta‐TC‐6 cells From Cholesterol‐Triggered Damage by Repressing Nfatc4. ABSTRACT Excessive cholesterol contributes to pancreatic β‐cell dysfunction and plays a critical role in the pathogenesis of metabolic disorders.
Pingping Hong, Yongjie Li, Jiandong Lin, Lingxiao Wang, Xiaofang Fan, Hongfang Wang, Luping Lou   +6 more
wiley   +1 more source

N6-methyladenosine (m6A)-circHECA facilitates the differentiation of SHF stem cells into hair follicle lineage through miR-449a-5p/LEF1 mediated Wnt/β-catenin pathway in cashmere goats. [PDF]

Anim Biosci
Fan Y, Hui T, Zhang Q, Xu R, Shen J, Zhu Y, Bai M, Bai W.   +7 more
europepmc   +1 more source

Polyphenism Through RNA Chemical Modifications

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley   +1 more source