Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik +10 more
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N6-methyladenosine (m<sup>6</sup>A) modification of TXNIP in 3'UTR instigates abdominal aorta aneurysm in mice. [PDF]
Hantelys F, Yin W, Zou MH.
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Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto +3 more
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Influenza NS1 drives N6-methyladenosine (m6A)-mediated autoregulation of viral mRNA splicing. [PDF]
Liao Y, Liu J, Wang P, Mok BW, Chen H.
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The role of circRNAs in N<sup>6</sup>-methyladenosine(m<sup>6</sup>A), cell death and clinical applications in human breast cancer. [PDF]
Chen S +6 more
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Landscape of N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation in porcine cells identifies candidate genes associated with porcine epidemic diarrhea virus infection. [PDF]
Dong X, Zhang Y, Wang Y, Wang C, Zhou A.
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Interaction between N6-methyladenosine (m<sup>6</sup>A) modification and toxicant-related neurodegeneration: From neural development to pathophysiology. [PDF]
She Z +10 more
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Mechanisms and clinical landscape of N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers. [PDF]
Zhu DH +7 more
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Novel N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) writer METTL16 promotes the cervical cancer tumorigenesis by targeting FTH1-dependent ferroptosis. [PDF]
Huang Z, Luo Y, Gao Q, Wang L, Li C.
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