Results 171 to 180 of about 16,968 (203)

The role of N6-methyladenosine (m6A) in eye diseases

Molecular Biology Reports, 2021
N6-methyladenosine (m6A) is the most common form of internal RNA modification in eukaryotes. The dynamic regulation of m6A modification mainly rely on three proteases, installed by m6A methyltransferase, removed by m6A demethylase and recognized by m6A reader protein, which regulates the metabolism of RNA, thereby regulating the processes of cell ...
Jing-Fan Gao, Lu Zhang
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Advances in the profiling of N6-methyladenosine (m6A) modifications

Biotechnology Advances, 2020
Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Hong-Xiang, Zheng, Xian-Sheng, Zhang, Na, Sui   +2 more
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The functions of N6-methyladenosine (m6A) RNA modifications in colorectal cancer

Medical Oncology, 2022
Colorectal cancers (CRC), which includes colon cancer (CC) and rectal cancer (RC), are some of the most common malignant tumors that are prone to distant metastasis. Its high incidence rate and high mortality rate have attracted much attention. In recent years, epigenetics has attracted increasing attention and has been the focus of many research ...
Haiyan Qiao, Linfeng Liu, Jun Chen, Bingbing Shang, Liang Wang   +4 more
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Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system

Journal of Zhejiang University: Science B, 2020
As the most prevalent and abundant transcriptional modification in the eukaryotic genome, the continuous and dynamic regulation of N6-methyladenosine (m6A) has been shown to play a vital role in physiological and pathological processes of cardiovascular diseases (CVDs), such as ischemic heart failure (HF), myocardial hypertrophy, myocardial infarction (
Zhao Kun, Xiangqing Kong
exaly   +4 more sources

Importance of m N6-methyladenosine (m6A) RNA modification in cancer

Medical Oncology, 2019
RNA methylation, which was identified back in 1970s, has gained remarkable interest in recent years as it was shown to be a reversible modification involved in many cellular processes like mRNA and miRNA processing, mRNA localisation, translation suppression, or activation.
Gulten Tuncel, Rasime Kalkan
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The role of N6-methyladenosine (m6A) modification in plants

Theoretical and Applied Genetics
N6-methyladenosine (m6A) modification is the most prevalent chemical modification identified in eukaryotic mRNA molecules, playing a pivotal role in plant growth, development, and responses to both biotic and abiotic stresses. m6A modification is co-regulated by methyltransferases and demethylases, with recognition proteins specifically binding to m6A ...
Cui-Xian Qin, Ao-Mei Li, Zhong-Liang Chen, Fen Liao, Miao Wang, You-Qiang Pan, Li Zhou, Bao-Qing Zhang, Jian-Hui Zhou, Dong-Liang Huang   +9 more
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Genome-Wide Location Analyses of N6-Methyladenosine Modifications (m6A-Seq) [PDF]

Methods in Molecular Biology, 2017
N6-methyladenosine-sequencing (m6A-seq) is a critical tool to obtain an unbiased genome-wide picture of m6A sites of modification at high resolution. It allows the study of the impact of various perturbations on m6A modification distribution and the study of m6A functions. Herein, we describe the m6A-seq protocol, which entails RNA immunoprecipitation (
Benoit Molinié
exaly   +3 more sources

Roles of RNA methylation by means of N6-methyladenosine (m6A) in human cancers

Cancer Letters, 2017
Reversible methylation by means of N6-methyladenosine (m6A) is the most prevalent internal modification in mammalian mRNA. This RNA chemical mark is created by proteins that are m6A "writers" and can be reversed by proteins that are m6A "erasers" (i.e., demethylases).
Siwei, Wang, Chunxiao, Sun, Jianhua, Li, Erbao, Zhang, Zhifei, Ma, Weizhang, Xu, Hong, Li, Mantang, Qiu, Youtao, Xu, Wenjia, Xia, Lin, Xu, Rong, Yin   +11 more
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Transcriptome-Wide Mapping of N6-Methyladenosine by m6A-Seq

2015
A detailed protocol for isolation and sequencing of an enriched population of m(6)A-methylated RNA fragments to create m(6)A methylome maps is outlined. Our approach was developed to fill a void that existed because of a lack of methods for the detection of m(6)A in RNA in an unbiased, high-throughput, and high-resolution manner. This method integrates
Dan Dominissini, Sharon Moshitch-Moshkovitz, Ninette Amariglio, Gideon Rechavi   +3 more
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Regulation of m6A (N6-Methyladenosine) methylation modifiers in solid cancers

Functional & Integrative Genomics
Solid cancers constitute a tremendous burden on global healthcare, requiring a deeper understanding of the molecular mechanisms underlying cancer development and progression. Epigenetic changes, notably N6-methyladenosine (m6A) RNA methylation, have emerged as important contributors to the biology of solid tumors in recent years.
Sakshi, Singh, Sudha, Gupta, Rajul, Abhishek, Manisha, Sachan   +3 more
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