Effects of N<sup>6</sup>-Methyladenosine (m<sup>6</sup>A) and 5-Methylcytosine (m<sup>5</sup>C) Modifications in the Guide Region of CRISPR RNA on Cas12a Nuclease Activity. [PDF]
Bioconjug ChemPandit B +5 more
europepmc +1 more source
N6-methyladenosine (m6A)-circHECA from secondary hair follicle of cashmere goats: identification, regulatory network and expression regulated potentially by methylation of its host gene promoter. [PDF]
Anim BiosciShen J +10 more
europepmc +1 more source
When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse? [PDF]
Vet ResWang W +8 more
europepmc +1 more source
Related searches:
N6‐methyladenosine (m6A) modification in gynecological malignancies
Journal of Cellular Physiology, 2022AbstractN6‐methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNA, regulated by m6A methyltransferase and demethylase. m6A modified RNA is specifically recognized and bound by m6A recognition proteins, which mediate splicing, maturation, exonucleation, degradation, and translation.
Ning Liu
exaly +3 more sources
N6-methyladenosine (m6A) methylation in kidney diseases: Mechanisms and therapeutic potential
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2023 The N6-methyladenosine (m6A) modification is regulated by methylases, commonly referred to as "writers," and demethylases, known as "erasers," leading to a dynamic and reversible process. Changes in m6A levels have been implicated in a wide range of cellular processes, including nuclear RNA export, mRNA metabolism, protein translation, and RNA splicing,
Hangyu Ji, Xuefei Zhao
exaly +3 more sources
N6‐methyladenosine (m6A) Modification in Preeclampsia
Reproductive Sciences, 2023Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang +6 more
openaire +2 more sources
Effect of circular RNAs and N6-methyladenosine (m6A) modification on cancer biology
Biomedicine and Pharmacotherapy, 2023 N6-methyladenosine (m6A), as the most abundant and well-known RNA modification, has been found to play an important role in cancer. Circular RNAs (circRNAs) are a class of single-stranded covalently closed RNA molecules generated by the reverse splicing process.
Gong Zhang
exaly +3 more sources
The role of N6-methyladenosine (m6A) in eye diseases
Molecular Biology Reports, 2021N6-methyladenosine (m6A) is the most common form of internal RNA modification in eukaryotes. The dynamic regulation of m6A modification mainly rely on three proteases, installed by m6A methyltransferase, removed by m6A demethylase and recognized by m6A reader protein, which regulates the metabolism of RNA, thereby regulating the processes of cell ...
Jing-Fan Gao, Lu Zhang
openaire +2 more sources
The functions of N6-methyladenosine (m6A) RNA modifications in colorectal cancer
Medical Oncology, 2022Colorectal cancers (CRC), which includes colon cancer (CC) and rectal cancer (RC), are some of the most common malignant tumors that are prone to distant metastasis. Its high incidence rate and high mortality rate have attracted much attention. In recent years, epigenetics has attracted increasing attention and has been the focus of many research ...
Haiyan Qiao +4 more
openaire +2 more sources
Advances in the profiling of N6-methyladenosine (m6A) modifications
Biotechnology Advances, 2020Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Hong-Xiang, Zheng +2 more
openaire +2 more sources