Results 181 to 190 of about 16,968 (203)

Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma

Gene
m6A regulators have important roles in a variety of autoimmune diseases, but their potential function in scleroderma, a refractory connective tissue disease, remains unclear. Tenascin C (TNC) is known to be a factor promoting collagen deposition in the development of scleroderma, but the regulatory relationship between TNC and m6A regulators is unknown.
Yue, Yu, Chen, Liang, Qinyu, Tang, Yuling, Shi, Liangliang, Shen   +4 more
openaire   +2 more sources

N6-methyladenosine (m6A) modification: Emerging regulators in plant-virus interactions

Virology
N6-methyladenosine (m6A), a reversible epigenetic modification, is widely present on both cellular and viral RNAs. This modification undergoes catalysis by methyltransferases (writers), removal by demethylases (erasers), and recognition by m6A-binding proteins (readers), ultimately influencing the fate and function of modified RNA molecules.
Yanjun Li, Zongtao Sun
exaly   +3 more sources

ALKBH8 as a potential N6 -methyladenosine (m6 A) eraser in insects.

Insect molecular biology, 2023
The N6 -methyladenosine (m6 A) machinery functions through three groups of proteins in eukaryotic cells, including m6 A writers, erasers and readers. The m6 A cellular machinery has mostly been characterised in mammalian species, and the relevant literature on insects is currently scant.
Dai, Zhenkai, Asgari, Sassan
openaire   +3 more sources

Functions of N6-methyladenosine (m6A) RNA modifications in acute myeloid leukemia

Journal of Leukocyte Biology
Abstract N6-methyladenosine is the most common modification of eukaryotic RNA. N6-methyladenosine participates in RNA splicing, nuclear export, translation, and degradation through regulation by methyltransferases, methylation readers, and demethylases, affecting messenger RNA stability and translation efficiency. Through the dynamic and
Zehao, Fang, Hanyi, Ding, Jiongping, Han, Leihua, Fu, Jing, Jin, Weiying, Feng   +5 more
openaire   +2 more sources

Prevalence of N6-methyladenosine (m6A) in mycoplasma mRNA:Epitranscriptomic regulation in minimal genomes

Microbial Pathogenesis
Messenger RNA N6 methyladenosine (m6A) modification has been considered as the main post-transcriptional modification of eukaryotic mRNA; however, its role in the regulation of prokaryotic mRNA transcription remains unclear. The N6 methyladenosine (m6A) modifications in prokaryotic mRNA has been found in Pseudomonas aeruginosa and Escherichia coli so ...
Suzi, Zhang, Yuyu, Zhang, Yi, Luo, Silan, Zhang, Yinjuan, Song, Bin, Li, Fuying, Zheng, Pengchen, Gao, Jian, Xu, Yuefeng, Chu   +9 more
openaire   +2 more sources

N6-methyladenosine (m6A) epitranscriptomics in synaptic plasticity and behaviors

Neuropsychopharmacology, 2022
Emir Malovic, Subhash C. Pandey
openaire   +1 more source

TS-m6A-DL: Tissue-specific identification of N6-methyladenosine sites using a universal deep learning model

Computational and Structural Biotechnology Journal, 2021
Zeeshan Abbas, Hilal Tayara, Quan Zou
exaly  

Regulation of Gene Expression Associated With the N6-Methyladenosine (m6A) Enzyme System and Its Significance in Cancer

Frontiers in Oncology, 2021
Tingting Yu
exaly  

M6A-BiNP: predicting N6-methyladenosine sites based on bidirectional position-specific propensities of polynucleotides and pointwise joint mutual information

RNA Biology, 2021
Mingzhao Wang, Juanying Xie, Sheng-Quan Xu   +2 more
exaly  

m6A-FORM: A Foundation Model for Decoding N6-methyladenosine Biology

N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. However, most existing predictors use adenosine-centered formulations that are computationally inefficient and prone to false positives. Here we present m6A-FORM, a transformer-based foundation model for RNA methylation that uses MeRIP-seq peaks as methylation ...
Zhang, Tinghe, Jo, Sumin, Gao, Shou-Jiang, Huang, Yufei   +3 more
openaire   +1 more source