Results 201 to 210 of about 17,129 (229)

Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system

Journal of Zhejiang University: Science B, 2020
As the most prevalent and abundant transcriptional modification in the eukaryotic genome, the continuous and dynamic regulation of N6-methyladenosine (m6A) has been shown to play a vital role in physiological and pathological processes of cardiovascular diseases (CVDs), such as ischemic heart failure (HF), myocardial hypertrophy, myocardial infarction (
Xiang-Qing Kong, Zhao Kun
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

The role of N6-methyladenosine (m6A) modification in plants

Theoretical and Applied Genetics
N6-methyladenosine (m6A) modification is the most prevalent chemical modification identified in eukaryotic mRNA molecules, playing a pivotal role in plant growth, development, and responses to both biotic and abiotic stresses. m6A modification is co-regulated by methyltransferases and demethylases, with recognition proteins specifically binding to m6A ...
Cui-Xian Qin, Ao-Mei Li, Zhong-Liang Chen, Fen Liao, Miao Wang, You-Qiang Pan, Li Zhou, Bao-Qing Zhang, Jian-Hui Zhou, Dong-Liang Huang   +9 more
openaire   +2 more sources

Importance of m N6-methyladenosine (m6A) RNA modification in cancer

Medical Oncology, 2019
RNA methylation, which was identified back in 1970s, has gained remarkable interest in recent years as it was shown to be a reversible modification involved in many cellular processes like mRNA and miRNA processing, mRNA localisation, translation suppression, or activation.
Gulten Tuncel, Rasime Kalkan
openaire   +2 more sources

Roles of RNA methylation by means of N6-methyladenosine (m6A) in human cancers

Cancer Letters, 2017
Reversible methylation by means of N6-methyladenosine (m6A) is the most prevalent internal modification in mammalian mRNA. This RNA chemical mark is created by proteins that are m6A "writers" and can be reversed by proteins that are m6A "erasers" (i.e., demethylases).
Siwei, Wang, Chunxiao, Sun, Jianhua, Li, Erbao, Zhang, Zhifei, Ma, Weizhang, Xu, Hong, Li, Mantang, Qiu, Youtao, Xu, Wenjia, Xia, Lin, Xu, Rong, Yin   +11 more
openaire   +2 more sources

RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential

Cancer Gene Therapy, 2023
Head and neck squamous cell carcinoma ranks seventh in incidence of malignant tumours in the world. Although there are treatments including surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy, drug resistance to treatment is caused by various reasons, and the survival rate of patients remains frustrating.
Xinyu, Sun, Shengqiao, Fu, Xiao, Yuan, Xi, Pu, RunKun, Wang, Xu, Wang, Hanqiang, Lu   +6 more
openaire   +2 more sources

Transcriptome-Wide Mapping of N6-Methyladenosine by m6A-Seq

2015
A detailed protocol for isolation and sequencing of an enriched population of m(6)A-methylated RNA fragments to create m(6)A methylome maps is outlined. Our approach was developed to fill a void that existed because of a lack of methods for the detection of m(6)A in RNA in an unbiased, high-throughput, and high-resolution manner. This method integrates
Dan Dominissini, Sharon Moshitch-Moshkovitz, Ninette Amariglio, Gideon Rechavi   +3 more
openaire   +1 more source

Regulation of m6A (N6-Methyladenosine) methylation modifiers in solid cancers

Functional & Integrative Genomics
Solid cancers constitute a tremendous burden on global healthcare, requiring a deeper understanding of the molecular mechanisms underlying cancer development and progression. Epigenetic changes, notably N6-methyladenosine (m6A) RNA methylation, have emerged as important contributors to the biology of solid tumors in recent years.
Sakshi, Singh, Sudha, Gupta, Rajul, Abhishek, Manisha, Sachan   +3 more
openaire   +2 more sources

Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma

Gene
m6A regulators have important roles in a variety of autoimmune diseases, but their potential function in scleroderma, a refractory connective tissue disease, remains unclear. Tenascin C (TNC) is known to be a factor promoting collagen deposition in the development of scleroderma, but the regulatory relationship between TNC and m6A regulators is unknown.
Yue, Yu, Chen, Liang, Qinyu, Tang, Yuling, Shi, Liangliang, Shen   +4 more
openaire   +2 more sources

N6-methyladenosine (m6A) modification: Emerging regulators in plant-virus interactions

Virology
N6-methyladenosine (m6A), a reversible epigenetic modification, is widely present on both cellular and viral RNAs. This modification undergoes catalysis by methyltransferases (writers), removal by demethylases (erasers), and recognition by m6A-binding proteins (readers), ultimately influencing the fate and function of modified RNA molecules.
Zongtao Sun
exaly   +3 more sources

Functions of N6-methyladenosine (m6A) RNA modifications in acute myeloid leukemia

Journal of Leukocyte Biology
Abstract N6-methyladenosine is the most common modification of eukaryotic RNA. N6-methyladenosine participates in RNA splicing, nuclear export, translation, and degradation through regulation by methyltransferases, methylation readers, and demethylases, affecting messenger RNA stability and translation efficiency. Through the dynamic and
Zehao, Fang, Hanyi, Ding, Jiongping, Han, Leihua, Fu, Jing, Jin, Weiying, Feng   +5 more
openaire   +2 more sources