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Transcriptome-Wide Mapping of N6-Methyladenosine by m6A-Seq
2015A detailed protocol for isolation and sequencing of an enriched population of m(6)A-methylated RNA fragments to create m(6)A methylome maps is outlined. Our approach was developed to fill a void that existed because of a lack of methods for the detection of m(6)A in RNA in an unbiased, high-throughput, and high-resolution manner. This method integrates
Dan Dominissini +3 more
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Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma
Genem6A regulators have important roles in a variety of autoimmune diseases, but their potential function in scleroderma, a refractory connective tissue disease, remains unclear. Tenascin C (TNC) is known to be a factor promoting collagen deposition in the development of scleroderma, but the regulatory relationship between TNC and m6A regulators is unknown.
Yue, Yu +4 more
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Functions of N6-methyladenosine (m6A) RNA modifications in acute myeloid leukemia
Journal of Leukocyte BiologyAbstract N6-methyladenosine is the most common modification of eukaryotic RNA. N6-methyladenosine participates in RNA splicing, nuclear export, translation, and degradation through regulation by methyltransferases, methylation readers, and demethylases, affecting messenger RNA stability and translation efficiency. Through the dynamic and
Zehao, Fang +5 more
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N6-methyladenosine (m6A) modification: Emerging regulators in plant-virus interactions
VirologyN6-methyladenosine (m6A), a reversible epigenetic modification, is widely present on both cellular and viral RNAs. This modification undergoes catalysis by methyltransferases (writers), removal by demethylases (erasers), and recognition by m6A-binding proteins (readers), ultimately influencing the fate and function of modified RNA molecules.
Jianping Chen, Zongtao Sun
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ALKBH8 as a potential N6 -methyladenosine (m6 A) eraser in insects.
Insect molecular biology, 2023The N6 -methyladenosine (m6 A) machinery functions through three groups of proteins in eukaryotic cells, including m6 A writers, erasers and readers. The m6 A cellular machinery has mostly been characterised in mammalian species, and the relevant literature on insects is currently scant.
Dai, Zhenkai, Asgari, Sassan
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Microbial Pathogenesis
Messenger RNA N6 methyladenosine (m6A) modification has been considered as the main post-transcriptional modification of eukaryotic mRNA; however, its role in the regulation of prokaryotic mRNA transcription remains unclear. The N6 methyladenosine (m6A) modifications in prokaryotic mRNA has been found in Pseudomonas aeruginosa and Escherichia coli so ...
Suzi, Zhang +9 more
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Messenger RNA N6 methyladenosine (m6A) modification has been considered as the main post-transcriptional modification of eukaryotic mRNA; however, its role in the regulation of prokaryotic mRNA transcription remains unclear. The N6 methyladenosine (m6A) modifications in prokaryotic mRNA has been found in Pseudomonas aeruginosa and Escherichia coli so ...
Suzi, Zhang +9 more
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N6-methyladenosine (m6A) epitranscriptomics in synaptic plasticity and behaviors
Neuropsychopharmacology, 2022Emir Malovic, Subhash C. Pandey
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