Results 61 to 70 of about 22,540 (229)

YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.

PLoS Biology, 2020
The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay ...
Qili Fei, Zhongyu Zou, Ian A Roundtree, Hui-Lung Sun, Chuan He   +4 more
doaj   +1 more source

Transcriptome-wide high-throughput deep m6A-seq reveals unique differential m6A methylation patterns between three organs in Arabidopsis thaliana [PDF]

, 2015
Proportion of two types of m6A distributing feature in mRNA.
Dayong Zhang, Kai Tang, Shaojun Xie, Xiaohong Zhu, Yizhen Wan, Zegang Wang, Zhaobo Lang   +6 more
core   +11 more sources

Inducible and reversible RNA N6-methyladenosine editing

Nature Communications, 2022
RNA modifications, including N6-methyladenosine (m6A), have been reported to regulate fundamental RNA processes and properties, and directly linked to various human diseases.
Huaxia Shi, Ying Xu, Na Tian, Ming Yang, Fu-Sen Liang   +4 more
doaj   +1 more source

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination [PDF]

, 2016
N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7.
A Hilfiker, B Moindrot, C Church, C Schütt, C Trapnell, CF Hongay, D Dominissini, D Kim, D Sturgill, D Yan, DP Patil, E Zaharieva, Eugenio Sanchez-Moran, GZ Luo, Helen K. Salz, Irmgard U. Haussmann, IU Haussmann, IU Haussmann, IU Haussmann, J Liu, J Zhou, JA Bokar, JE Harper, JT Robinson, K Horiuchi, KD Meyer, KD Meyer, KJ Livak, LO Penalva, M Niessen, M Soller, M Soller, M Soller, Matthias Soller, Nathan Archer, Nigel P. Mongan, RP Perry, Rupert G. Fray, S Geula, S Ke, S Luo, S Schwartz, S Zhong, SR Starck, W Xiao, X Wang, Z Bodi, Z Bodi, Zsuzsanna Bodi   +48 more
core   +5 more sources

N6-methyladenosine (m6A) modification in hepatocellular carcinoma

Biomedicine & Pharmacotherapy
Hepatocellular carcinoma (HCC) is one of the deadliest cancers of human, the tumor-related death of which ranks third among the common malignances. N6-methyladenosine (m6A) methylation, the most abundant internal modification of RNA in mammals, participates in the metabolism of mRNA and interrelates with ncRNAs. In this paper, we overviewed the complex
Hehua Ma, Yuxin Hong, Zhenzhen Xu, Zuyi Weng, Yuanxun Yang, Dandan Jin, Zhiyou Chen, Jing Yue, Xuan Zhou, Zhi Xu, Fei Fei, Juan Li, Wei Song   +12 more
openaire   +2 more sources

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Nature Communications, 2020
The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A ...
Song Zhu, Ji-Zhong Wang, De Chen, Yu-Tian He, Nan Meng, Min Chen, Rui-Xun Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan   +9 more
doaj   +1 more source

Effect of methylation of adenine N6 on kink turn structure depends on location [PDF]

, 2019
N6-methyladenine is the most common covalent modification in cellular RNA species, with demonstrated functional consequences. At the molecular level this methylation could alter local RNA structure, and/or modulate the binding of specific proteins.
Bokar JA, David M. J. Lilley, Lin Huang, Saira Ashraf   +3 more
core   +2 more sources

The emerging roles and mechanism of N6-methyladenosine (m6A) modifications in urologic tumours progression

Frontiers in Pharmacology, 2023
Prostate cancer (PCa), bladder cancer (BC), and renal cell cancer (RCC) are the most common urologic tumours in males. N6-methyladenosine (m6A), adenosine N6 methylation, is the most prevalent RNA modification in mammals.
Wenhao Zhu, Renshan Zhao, Xiaomin Guan, Xu Wang   +3 more
doaj   +1 more source

m^6A RNA methylation promotes XIST-mediated transcriptional repression [PDF]

, 2016
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N^6-methyladenosine (m^6A) residues—a ...
A Minajigi, A Wutz, A Wutz, AJ Link, AM Hartmann, Amy Chow, B Linder, B Moindrot, Brian F. Pickering, C Chu, CA McHugh, Chun-Kan Chen, CM Wei, Constanza Jackson, CR Alarcón, D Dominissini, Deepak P. Patil, F Ramírez, FL Wilkinson, G Jia, G Singh, GD Penny, H Uranishi, I Huppertz, J Kochan, J König, J Schindelin, J Zhao, JA Bokar, JM Engreitz, K Horiuchi, K Morohashi, K Plath, KD Meyer, KD Meyer, KD Meyer, L Berglund, L Bylund, Mitchell Guttman, MJ Cowley, N Liu, P Shannon, Q Cao, S Geula, S Heinz, S Niranjanakumari, S Schwartz, S Zhong, Samie R. Jaffrey, SC Kwon, SD Agarwala, SM Weyn-Vanhentenryck, W Ma, W Xiao, X Wang, X Wang, XL Ping, Y Hasegawa, YC Lin   +58 more
core   +2 more sources

Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives [PDF]

, 2021
Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors.
Biancari, Fausto, Blokhina, Daria, Bäckström, Pia, Dahlbacka, Sebastian, Elomaa, Outi, Eskin, Arda, Jormalainen, Mikko, Juvonen, Tatu, Kaarne, Markku, Kankuri, Esko, Karelson, Mati, Karjalainen, Pasi, Katayama, Shintaro, Khan, Jahangir, Kiss, Jan, Koivisto, Pertti, Laine, Mika, Lalowski, Maciej, Laurikka, Jari, Lemström, Karl, Mervaala, Eero, Nummi, Annu, Nykänen, Antti, Oksaharju, Kati, Raivio, Peter, Rajala, Helena, Ropponen, Jussi, Savinainen, Kimmo, Sikorski, Vilbert, Simpanen, Jarmo, Stark, Christoffer, Suihko, Satu, Syrjälä, Simo, Teittinen, Kari, Tuncbag, Nurcan, Tuohinen, Suvi, Vainikka, Tiina, Vento, Antti, Vähäsilta, Tommi   +38 more
core   +6 more sources