Results 131 to 140 of about 49,721 (234)
Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley +1 more source
Recent studies demonstrate that near‐infrared (NIR—750–980 nm)‐mediated photodynamic (PDT) and photothermal (PTT) therapies, combined with metallic nanoparticles (MNPs), show promising results against skin cancer, particularly melanoma, in both in vitro and in vivo models.
Tamyris Devincenzi +3 more
wiley +1 more source
In this phase 2 study (NCT05047991), patients with unresectable metastatic pancreatic adenocarcinoma were randomized to receive NALIRIFOX (liposomal irinotecan, 5-FU, leucovorin, and oxaliplatin) or gemcitabine plus nab-paclitaxel.
Chuntao Gao +35 more
doaj +1 more source
The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas +5 more
wiley +1 more source
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley +1 more source
ABSTRACT Duodenal self‐expandable metal stents (SEMS) are widely used to treat malignant gastric outlet obstruction (GOO). However, stent migration is a well‐known complication. We report a rare case of small‐bowel impaction caused by the migration of a duodenal SEMS with a biliary plastic stent (PS).
Shinsuke Otagiri +9 more
wiley +1 more source

