Results 111 to 120 of about 76,340 (268)

Tribendimidine: Mode of Action and nAChR Subtype Selectivity in Ascaris and Oesophagostomum

PLoS Neglected Tropical Diseases, 2015
The cholinergic class of anthelmintic drugs is used for the control of parasitic nematodes. One of this class of drugs, tribendimidine (a symmetrical diamidine derivative, of amidantel), was developed in China for use in humans in the mid-1980s. It has a
A. Robertson, Sreekanth Puttachary, Samuel K Buxton, R. Martin   +3 more
semanticscholar   +1 more source

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis, Philippe Danjou, Mark Smith, Spyros Papapetropoulos   +7 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Structural basis for allosteric agonism of human α7 nicotinic acetylcholine receptors

Cell Discovery
The α7 nicotinic acetylcholine receptor (nAChR), a pentameric ligand-gated ion channel, plays important roles in cognition, neuroprotection, and anti-inflammation.
Sanling Liu, Yining Zheng, Haopeng Chen, Xin Li, Qipeng Yan, Wenjun Mu, Yaning Fu, Huan Chen, Hongwei Hou, Lei Liu, Changlin Tian   +10 more
doaj   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Riemann-Liouville Fractional Cosine Functions

, 2015
In this paper, a new notion, named Riemann-Liouville fractional cosine function is presented. It is proved that a Riemann-Liouville $\alpha$-order fractional cosine function is equivalent to Riemann-Liouville $\alpha$-order fractional resolvents ...
Mei, Zhan-Dong, Peng, Ji-Gen
core   +1 more source

Distinctive Roles for α7*- and α9*-Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Frontiers in Cellular Neuroscience, 2017
Previous studies have demonstrated immunosuppressive and anti-inflammatory effects of nicotine, including in the experimental autoimmune encephalomyelitis (EAE) model in mice of some forms of multiple sclerosis (MS).
Qiang Liu, Paul Whiteaker, Barbara J. Morley, Fu-Dong Shi, Ronald J. Lukas   +4 more
doaj   +1 more source

Dual impact of smoking cessation and post‐cessation weight change on psoriasis

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 285-295, February 2026.
Although smoking cessation generally reduced the risk of psoriasis, especially psoriasis vulgaris and palmoplantar pustulosis, post‐cessation weight gain weakened this benefit, mainly for psoriasis vulgaris. Nonetheless, cessation maintained a substantial protective effect against palmoplantar pustulosis, and long‐term advantages outweighed the adverse
Seong Rae Kim, Young‐Geun Choi, Seong Jin Jo   +2 more
wiley   +1 more source

Establishing an Ion Pair Interaction in the Homomeric {rho}1 {gamma}-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway [PDF]

, 2007
{gamma}-Aminobutyric acid type A (GABAA) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. Upon agonist binding, the receptor undergoes a structural transition from the closed to the open state, but the mechanism of gating ...
Dougherty, Dennis A., Lester, Henry A., Wang, Jinti   +2 more
core