Results 101 to 110 of about 10,119 (138)

PET Brain imaging of α7-nAChR with [¹⁸F]ASEM

, 2018
The α7 nicotinic acetylcholine receptor (nAChR) increasingly has been implicated in normal brain physiology, as well as in neuropsychiatric disorders.
Heather Valentine, Albert Gjedde, Elise M. Weerts, Nicola Casella, Gary Wand, Andrew G. Horti, Noble George, Michael McDonald, Kelly Kitzmiller, Lorena Gapasin, Robert Freedman, William Kem, James Brasic, Jenny A. Phan, Hiroto Kuwabara, Ayon Nandi, Akira Sawa, Dean F. Wong, Joshua M. Roberts   +18 more
core   +1 more source

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10

Frontiers in Cellular Neuroscience, 2017
Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of α7, α9 and/or α10 subunits ...
Anna Zakrzewicz, Katrin Richter, Alisa Agné, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Mike Althaus, Mike Althaus, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Veronika Grau, Veronika Grau   +17 more
doaj   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Nicotine promoted BGC823 cell proliferation through α5-nAChR.

, 2016
A: BGC823 were exposed to nicotine (0, 1, 10, 100, 500, 1000μM) for 24, 48, and 72h, respectively. Nicotine promoted cell proliferation in a time-dependent and concentration-dependent relation; B: Treatment of nicotine at the dose of nicotine (0, 1, 10 ...
Huilin Zhang (435434), Dongjie Xiao (286063), Haiji Sun (2513482), Xiuping Zhang (334570), Yanfei Jia (286060), Yunshan Wang (286067), Hongqiao Wu (2513485), Xiaoli Ma (88826)   +7 more
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Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure [PDF]

, 2020
The identification of biomarkers that are altered following nicotine/tobacco exposure can facilitate the investigation of tobacco-related diseases. Nicotinic acetylcholine receptors (nAChRs) are pentameric cation channels expressed in the mammalian ...
Huard, Stephanie M., Mulcahy, Matthew J., Lester, Henry A., Wang, Jonathan H., Henderson, Brandon J., Paulo, Joao A., McKinney, Sheri   +6 more
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α7 Nicotinic Acetylcholine Receptor: From Structural Mechanisms to Therapeutic Translation

Shengwu huaxue yu shengwu wuli jinzhan
The α7 nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated ion channel characterized by high Ca2+ permeability, rapid activation, and rapid desensitization. It is widely expressed in the nervous system and various non-neuronal cell types.
LIU Yu-Han, CHEN Jiao-Feng, WANG Hong-Juan, CHEN Huan, HOU Hong-Wei   +4 more
doaj   +1 more source

Overall architecture of lynx1 at α4:α4 nAChR interface.

, 2018
Molecular dynamic simulations of lynx1 binding to α4 nAChR subunits. The cell membrane is represented as a dashed line.
Huaixing Wang (402224), Samantha A. Eichelberger (5478743), Carly Garrison (5478731), Kristin R. Anderson (5478734), Kasarah Ackerman (5478740), Julie M. Miwa (300237), Neel I. Nissen (5478737), Hui Sun Lee (389370), Wonpil Im (79057)   +8 more
core   +1 more source

Adult-onset hippocampal α7 nicotinic acetylcholine receptor loss rapidly drives Alzheimer-like neuropathology in mice

Frontiers in Pharmacology
IntroductionThe reduction of α7 nicotinic acetylcholine receptor (nAChR) in the hippocampus con-stitutes one of the neuropathological features observed in the brains of individuals with Alzheimer’s disease (AD), and α7 nAChR is crucial to cognitive ...
Jun Li, Jun Li, Jun Li, Guanglin Liu, Guanglin Liu, Guanglin Liu, Xiaotong Wang, Zheng Song, Huan Chen, Hongwei Hou, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu   +12 more
doaj   +1 more source

Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure

, 2019
The identification of biomarkers that are altered following nicotine/tobacco exposure can facilitate the investigation of tobacco-related diseases. Nicotinic acetylcholine receptors (nAChRs) are pentameric cation channels expressed in the mammalian ...
Sheri McKinney (7552472), Brandon J. Henderson, Jonathan H. Wang, Matthew J. Mulcahy (7552463), Joao A. Paulo (397190), Henry A. Lester, Joao A. Paulo, Brandon J. Henderson (205764), Henry A. Lester (201363), Stephanie M. Huard, Sheri McKinney, Matthew J. Mulcahy, Stephanie M. Huard (7552466), Jonathan H. Wang (7552469)   +13 more
core   +1 more source

Generation and characterisation of specific antibodies directed against subunits of nAChR and the biochemical properties of distinct nAChR in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes

, 2011
Nicotinic acetylcholine receptors (nAChR) mediate fast synaptic transmission in ganglia of the autonomic nervous system. Their biophysical and pharmacological properties are critically determined by their subunit composition.
David, Reinhard
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