Results 111 to 120 of about 10,119 (138)

Molecular Dynamics Investigation of Alphaconotoxin Si Binding To Nachr

, 2015
Nikotinik Asetilkolin Reseptörler (nAChR) analjezikler gibi ilaçların keşfinde önemli bir rol oynamaktadır. Alfa-konotoksin SI (SI) koni salyangozun zehrinde bulunan 13 aminoasitli bir peptiddir.
Baştuğ, Turgut, Tuna, Onur
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Comparison of the nAChR gene family in select insects.

Comparison of the nAChR gene family in select insects.
Rong Zhang (44942), Xu-Guo Zhou (6062825), You-Jun Zhang (2578120), Chris Bass (77286), Cheng Yin (11546544), Jin-Jin Liang (15430974), Ralf Nauen (841045), He Du (5466140), Qi-Mei Tan (17996489), Cheng-Jia Zhang (6732659), Wen Xie (104834), Dong Chu (171095), Hu Xue (14514693), Xue-Gao Wei (15430965), Han-Tang Lu (17996492), Xin Yang (104842), Bu-Li Fu (15430968), Andrias O. O’Reilly (148537), Jin-Yu Hu (2872769), Yao Ji (8900297), Pei-Pan Gong (15430971), Shao-Nan Liu (3355625), Lian-You Gui (15430959), Tian-Hua Du (15430962), Jing Yang (13969), Chao He (466651), Ming-Jiao Huang (12431181), Chao Wang (146527)   +27 more
core   +1 more source

Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig

Frontiers in Neuroimaging
The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen, Janus H. Magnussen, Anders Ettrup, Szabolcs Lehel, Dan Peters, Agnete Dyssegaard, Morten S. Thomsen, Morten S. Thomsen, Jens D. Mikkelsen, Jens D. Mikkelsen, Gitte M. Knudsen, Gitte M. Knudsen   +11 more
doaj   +1 more source

α7-nAChR knockout abrogates insulin sensitizing effect of nicotine.

, 2013
(A) Genotype characterization by PCR analysis of tail DNA from offspring derived from heterozygous intercrosses. Expected fragment sizes of the wild-type mice (+/+; 440 bp), heterozygous knockout mice (+/−, 440 bp and 750 bp) and homozygotous knockout ...
Jie Song (60883), Benoit Viollet (45915), Ying-Ying Le (294422), Chao-Yu Miao (294423), Ling-Ling Guo (294420), Pei Wang (102036), Tian-Ying Xu (294418)   +6 more
core   +1 more source

Curcumin Derivatives as Allosteric Modulator of α7-nAChR: Functional and Molecular Docking Insights

Medical Principles and Practice
Background: Curcumin has emerged as promising candidate for therapeutic modulation of neurodegenerative disorders by acting on α7-nicotinic acetylcholine receptor (α7-nAChR).
Eslam ElNebrisi, Mohammad A. Ghattas, Noor Atatreh, Sonia Hasan, Murat Oz   +4 more
doaj   +1 more source

Pharmacological properties of nAChR ligands on iPSC-derived neurons.

, 2015
Data are means ± SEM of 3–5 independent experiments.Pharmacological properties of nAChR ligands on iPSC-derived neurons.
Antoine Fouillet (729066), Anna Chatzidaki (286476), Jeffrey Dage (729068), Daniel Ursu (286479), Jingling Li (729067), Neil S. Millar (246746), Emanuele Sher (286485)   +6 more
core   +1 more source

State-dependent binding of cholesterol and an anionic lipid to the muscle-type Torpedo nicotinic acetylcholine receptor

Communications Biology
The ability of the Torpedo nicotinic acetylcholine receptor (nAChR) to undergo agonist-induced conformational transitions requires the presence of cholesterol and/or anionic lipids.
Anna Ananchenko, Rui Yan Gao, François Dehez, John E. Baenziger   +3 more
doaj   +1 more source

Molecular dynamics simulations of a4b2 nAChR receptor with epibatidine

<p>Molecular dynamics simulation trajectories of a4b2 nAChR receptor widetype and mutations with epibatidine</p ...
Chen, Fan
core   +1 more source

Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes

PDZ domains are modular domains that conventionally bind to C terminal or internal motifs of target proteins to control cellular functions through the regulation of protein complex assemblies.
Vasyl Bondarenko (1307439), Yan Xu (14594), Tommy S. Tillman (14670456), Qiang Chen (114038), Pei Tang (411379)   +4 more
core   +1 more source

Nachr Alfa-7'nin Sinaptik Plastisite Üzerine Etkilerinin Olfaktör Bulbus Ve Hippokampus Organotipik Kesit Kültürlerinde İncelenmesi

, 2018
15.08.2018Olfaktör bulbus koku bilgisinin işlendiği beyin bölgesidir. Olfaktör bulbus ön beyinden gelen kuvvetli kolinerjik girdileri almaktadır ve yüksek seviyede nikotinik asetilkolin reseptörü (nAChR) içermektedir.
Yılmazer, Selma
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