Results 121 to 130 of about 76,340 (268)

Does Abnormal Expression of Acetylcholine Receptors in Hirschsprung's Disease Induce Acetylcholine Esterase Positive Nerve Fibres?

Asian Journal of Surgery, 2007
Alpha bungarotoxin (α-BTX) is a neurotoxin isolated from the venom of Bungarus multicinctus that binds specifically to the β-subunits of nicotinic acetylcholine receptors (nAChR) on myotube membranes.
Junichi Kusafuka, Hiroyuki Kobayashi, Katsumi Miyahara, Geoffrey J. Lane, Noriyoshi Sueyoshi, Atsuyuki Yamataka   +5 more
doaj   +1 more source

Nicotine Induces the Production of IL-1ß and IL-8 via the a7 nAChR/NF-κB Pathway in Human Periodontal Ligament Cells: an in Vitro Study

Cellular Physiology and Biochemistry, 2014
Background/Aims: Tobacco smoking is a major risk factor for the occurrence and progression of periodontitis. We previously demonstrated that nicotine could induce the expression of a7 nicotinic acetylcholine receptors (a7 nAChR) in human and rat ...
Lizheng Wu, Yongchuan Zhou, Zhifei Zhou, Yingfeng Liu, Yudi Bai, Xiang-hui Xing, Xiaojing Wang   +6 more
semanticscholar   +1 more source

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. [PDF]

, 2015
Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits.
D'Oyley, JM, Dhankher, P, Gill-Thind, JK, Millar, NS, Sheppard, TD   +4 more
core  

6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor

Marine Drugs, 2015
6-Bromohypaphorine (6-BHP) has been isolated from the marine sponges Pachymatisma johnstoni, Aplysina sp., and the tunicate Aplidium conicum, but data on its biological activity were not available.
Igor E. Kasheverov, Irina V. Shelukhina, Denis S. Kudryavtsev, Tatyana N. Makarieva, Ekaterina N. Spirova, Alla G. Guzii, Valentin A. Stonik, Victor I. Tsetlin   +7 more
doaj   +1 more source

Real Time Ligand-Induced Motion Mappings of AChBP and nAChR Using X-ray Single Molecule Tracking

Scientific Reports, 2014
We observed the dynamic three-dimensional (3D) single molecule behaviour of acetylcholine-binding protein (AChBP) and nicotinic acetylcholine receptor (nAChR) using a single molecule tracking technique, diffracted X-ray tracking (DXT) with atomic scale ...
H. Sekiguchi, Yasuhito Suzuki, Yuri Nishino, Suzuko Kobayashi, Y. Shimoyama, Weiyan Cai, K. Nagata, M. Okada, K. Ichiyanagi, N. Ohta, N. Yagi, A. Miyazawa, T. Kubo, Y. Sasaki   +13 more
semanticscholar   +1 more source

Measuring the Spatial Arrangement of Nmj-Nachr ion Channel Proteins in the Cell Membrane [PDF]

, 2011
Hannah A. DeBerg, Nir Friedman, Cong Tien Nguyen, Paul D. Simonson, Paul R. Selvin   +4 more
openalex   +1 more source

Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration [PDF]

, 2022
Melissa A. Tapia, Xiao‐Tao Jin, Brenton R. Tucker, Leanne N. Thomas, Noah B. Walker, Veronica J. Kim, Steven E. Albertson, Naresh Damuka, Ivan Krizan, Seby Edassery, Jeffrey N. Savas, Kiran Kumar Solingapuram Sai, Sara R. Jones, Ryan M. Drenan   +13 more
openalex   +1 more source

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site [PDF]

, 2004
To study conformational transitions at the muscle nicotinic acetylcholine (ACh) receptor (nAChR), a rhodamine fluorophore was tethered to a Cys side chain introduced at the beta-19' position in the M2 region of the nAChR expressed in Xenopus oocytes ...
Auyeung, Vincent C., Bezanilla, Francisco, Chanda, Baron, Dahan, David S., Dibas, Mohammed I., Dougherty, Dennis A., Lester, Henry A., Petersson, E. James   +7 more
core  

The Activity of GAT107, an Allosteric Activator and Positive Modulator of α7 Nicotinic Acetylcholine Receptors (nAChR), Is Regulated by Aromatic Amino Acids That Span the Subunit Interface*

Journal of Biological Chemistry, 2013
Background: Nicotinic acetylcholine receptors are activated by agonists at an orthosteric site and modulated by ligands at allosteric sites. Results: We identify amino acids required for the coupling between orthosteric and allosteric sites.
R. Papke, N. Horenstein, Abhijit R. Kulkarni, C. Stokes, L. W. Corrie, C. Maeng, G. Thakur   +6 more
semanticscholar   +1 more source

Nicotine Induces the Up-regulation of the α7-Nicotinic Receptor (α7-nAChR) in Human Squamous Cell Lung Cancer Cells via the Sp1/GATA Protein Pathway

Journal of Biological Chemistry, 2013
Background: Nicotine promotes the proliferation of human squamous cell lung cancer (SCC-L) via the α7-nicotinic receptor (nAChR). Results: Nicotine increases α7-nAChR expression via transcriptional mechanisms involving Sp1 and GATA proteins.
K. Brown, H. Perry, Jamie K. Lau, Dennie V. Jones, J. Pulliam, Brent A. Thornhill, Clayton M. Crabtree, Haitao Luo, Y. Chen, P. Dasgupta   +9 more
semanticscholar   +1 more source