Results 21 to 30 of about 76,340 (268)

Inflammation Regulation via an Agonist and Antagonists of α7 Nicotinic Acetylcholine Receptors in RAW264.7 Macrophages

Marine Drugs, 2022
The α7 nicotinic acetylcholine receptor (nAChR) is widely distributed in the central and peripheral nervous systems and is closely related to a variety of nervous system diseases and inflammatory responses.
Yao Tan, Zhaoli Chu, Hongyu Shan, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo   +5 more
doaj   +1 more source

Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System

Biomolecules, 2020
Cholines acylated with unsaturated fatty acids are a recently discovered family of endogenous lipids. However, the data on the biological activity of acylcholines remain very limited.
Mikhail G. Akimov, Denis S. Kudryavtsev, Elena V. Kryukova, Elena V. Fomina-Ageeva, Stanislav S. Zakharov, Natalia M. Gretskaya, Galina N. Zinchenko, Igor V. Serkov, Galina F. Makhaeva, Natalia P. Boltneva, Nadezhda V. Kovaleva, Olga G. Serebryakova, Sofya V. Lushchekina, Victor A. Palikov, Yulia Palikova, Igor A. Dyachenko, Igor E. Kasheverov, Victor I. Tsetlin, Vladimir V. Bezuglov   +18 more
doaj   +1 more source

Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. [PDF]

PLoS ONE, 2011
The α7 nicotinic acetylcholine receptor (nAChR) is a potential target for the treatment of cognitive deficits in patients with schizophrenia, ADHD and Alzheimer's disease.
Morten S Thomsen, Mona El-Sayed, Jens D Mikkelsen   +2 more
doaj   +1 more source

Nicotinic Acetylcholine Receptors in the Respiratory Tract

Molecules, 2021
Nicotinic acetylcholine receptors (nAChR) are widely distributed in neuronal and non-neuronal tissues, where they play diverse physiological roles. In this review, we highlight the recent findings regarding the role of nAChR in the respiratory tract with
Monika I. Hollenhorst, Gabriela Krasteva-Christ   +1 more
doaj   +1 more source

Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells [PDF]

, 2016
In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol.
Alkahtan, Reem M., Grider, John R., Lyall, Vijay, Mahavadi, Sunila, Mummalaneni, Shobha K., Murthy, Karnam S., Qian, Jie   +6 more
core   +7 more sources

Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway

Aging, 2020
Ligands of nicotinic acetylcholine receptors (nAChRs) are widely considered as potential therapeutic agents. The present study used primary hippocampus cells and APPswe/PSEN1dE9 double-transgenic mice models to study the possible therapeutic effect and ...
Xiaoling Wang, Yuxin Deng, Yumei Gao, Yangting Dong, Fan Wang, Z. Guan, Wei Hong, X. Qi   +7 more
semanticscholar   +1 more source

Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription

Cell Insight, 2022
Alpha7 nicotinic acetylcholine receptor (α7 nAChR), a hub of the cholinergic anti-inflammatory pathway (CAP), is required for the treatment of inflammatory diseases.
Jing Wen, Caiqi Zhao, Jie Chen, Shuting Song, Zhekai Lin, Shitao Xie, Huaxin Qi, Jianhua Wang, Xiao Su   +8 more
doaj   +1 more source

A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy

Marine Drugs, 2022
α6β4 nAChR is expressed in the peripheral and central nervous systems and is associated with pain, addiction, and movement disorders. Natural α-conotoxins (α-CTxs) can effectively block different nAChR subtypes with higher efficacy and selectivity ...
Liujun Wang, Xixi Wu, Xiaopeng Zhu, Dongting Zhangsun, Yong Wu, Sulan Luo   +5 more
doaj   +1 more source

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

Antioxidants, 2020
Microglia controls the immune system response in the brain. Specifically, the activation and dysregulation of the NLRP3 inflammasome is responsible for the initiation of the inflammatory process through IL-1β and IL-18 release.
Víctor Farré-Alins, Paloma Narros-Fernández, A. Palomino-Antolin, Céline Decouty-Pérez, A. Lopez-Rodriguez, E. Parada, Alicia Muñoz-Montero, V. Gómez-Rangel, F. López-Muñoz, E. Ramos, Á. González-Rodríguez, L. Gandía, A. Romero, J. Egea   +13 more
semanticscholar   +1 more source

Nicotinic-nAChR signaling mediates drug resistance in lung cancer

Journal of Cancer, 2020
Lung cancer is the leading cause of cancer death worldwide. Cigarette smoking is the most common risk factor for lung carcinoma; other risks include genetic factors and exposure to radon gas, asbestos, secondhand smoke, and air pollution.
Wan-Li Cheng, Kuan‐Yuan Chen, Kang-Yun Lee, P. Feng, Sheng-Ming Wu   +4 more
semanticscholar   +1 more source