Results 31 to 40 of about 10,119 (138)

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

Modulation Of Recombinant α2* α3* Or α4*-Nicotinic Acetylcholine Receptor (Nachr) Function By Nachr β3 Subunits

, 2012
The nicotinic acetylcholine receptor (nAChR) β3 subunit is thought to serve an accessory role in nAChR subtypes expressed in dopaminergic regions implicated in drug dependence and reward.
Dash, Bhagirathi, Chang, Yongchang, Bhakta, Minoti, Lukas, Ronald J.   +3 more
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Human Kidney Cells Express nAChR subunits.

, 2013
To assess nAChR protein levels, (A) HK-2, (B) HRGECs, and (C) HMCs were analyzed by flow cytometry using specific antibodies against the α7nAChR (green, thick solid line), α4nAChR (pink, dotted line), and β2nAChR (blue, thin solid line) vs.
Prodyot K. Chatterjee (323552), Xiangying Xue (323558), Michael M. Yeboah (323554), Saul R. Powell (323559), Yousef Al-Abed (93844), Christine N. Metz (323560), Oonagh Dowling (323556)   +6 more
core   +1 more source

Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning [PDF]

, 2018
Cognitive impairments, e.g., reward learning, are present in various psychiatric disorders and warrant treatment. Improving reward-related learning could synergistically enhance psychosocial treatments and cognition generally. A critical first step is to
Twamley, Elizabeth W., Higa, Kerin K, Geyer, Mark A., Groenink, Lucianne, Higa, Kerin K., Deben, Debbie, Pharmacology, Milienne-Petiot, Morgane, Geyer, Mark A, Afd Pharmacology, Grim, Andrea, Young, Jared W., Young, Jared W, Twamley, Elizabeth W   +13 more
core   +2 more sources

Single-cell quantitative expression of nicotinic acetylcholine receptor mRNA in rat hippocampal interneurons.

PLoS ONE
Hippocampal interneurons are a very diverse population of cells. Using single-cell quantitative PCR to analyze rat CA1 hippocampal interneurons, we quantified neuronal nicotinic acetylcholine receptor (nAChR) mRNA subunit expression and detailed possible
Doris C Jackson, Richard M Burgon, Spencer Thompson, Sterling N Sudweeks   +3 more
doaj   +1 more source

Impaired Expression of Neuregulin 1 and Nicotinic Acetylcholine Receptor β4 Subunit in Diverticular Disease

Frontiers in Cellular Neuroscience, 2019
Neuregulin 1 (NRG1) regulates the expression of the nicotinic acetylcholine receptor (nAChR) and is suggested to promote the survival and maintenance of the enteric nervous system (ENS), since deficiency of its corresponding receptor complex ErbB2/ErbB3 ...
Martina Barrenschee, François Cossais, Martina Böttner, Jan-Hendrik Egberts, Thomas Becker, Thilo Wedel   +5 more
doaj   +1 more source

Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor. [PDF]

PLoS ONE, 2008
BACKGROUND: Cigarette smoking adversely affects endochondral ossification during the course of skeletal growth. Among a plethora of cigarette chemicals, nicotine is one of the primary candidate compounds responsible for the cause of smoking-induced ...
Atsuo Kawakita, Kazuki Sato, Hatsune Makino, Hiroyasu Ikegami, Shinichiro Takayama, Yoshiaki Toyama, Akihiro Umezawa   +6 more
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Confirmation of α7 nAChR surface expression on mouse macrophages.

, 2019
(A) PCR analysis showing a band of 264 bp size confirming the presence of α7 nAChR mRNA in macrophages isolated from WT but not α7 nAChR knockout mice. The 100 base pair ladder was from New England Biolabs. No RT: No reverse transcriptase control.
Brijesh K. Garg (6556034), Ralph H. Loring (6556037)   +1 more
core   +1 more source