Results 21 to 30 of about 10,119 (138)

in situ hybridization of alpha7 nAChR

, 2019
in situ hybridization of alpha7 nAChR in hippocampal and septal brain slices from mice with floxed a7 nAChR crossed with Cre lines expressed under Gad2, CaMKII, and Sst ...
Zhenglin Gu (7174931)
core   +2 more sources

Reporter Mutation Studies Show That Nicotinic Acetylcholine Receptor (nAChR) α5 Subunits and/or Variants Modulate Function of α6*-nAChR [PDF]

, 2011
To further the understanding of functional α6α5*- nicotinic acetylcholine receptors (nAChR; the asterisk (*) indicates known or possible presence of other subunits), we have heterologously expressed in oocytes different, mouse or human, nAChR subunit ...
Dash, Bhagirathi, Bhagirathi Dash, Chang, Yongchang, Yongchang Chang, Lukas, Ronald J., Ronald J. Lukas   +5 more
core   +1 more source

α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice

Marine Drugs, 2020
Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom.
Xiaodan Li, Shen You, Jian Xiong, Yamin Qiao, Jinpeng Yu, Dongting Zhangsun, Sulan Luo   +6 more
doaj   +1 more source

Nicotine Elevated Intracellular Ca2+ in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating α7-Nicotinic Acetylcholine Receptor

Cellular Physiology and Biochemistry, 2014
Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with airway smooth muscle (ASM) hypertrophy and hyperplasia.
Yongliang Jiang, Aiguo Dai, Yumin Zhou, Gongyong Peng, Guoping Hu, Bing Li, James S.K. Sham, Pixin Ran   +7 more
doaj   +1 more source

αO-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with α9 Nicotine Acetylcholine Receptors

Marine Drugs, 2020
The α9-containing nicotinic acetylcholine receptor (nAChR) is increasingly emerging as a new tumor target owing to its high expression specificity in breast cancer. αO-Conotoxin GeXIVA is a potent antagonist of α9α10 nAChR.
Zhihua Sun, Jiaolin Bao, Manqi Zhangsun, Shuai Dong, Dongting Zhangsun, Sulan Luo   +5 more
doaj   +1 more source

Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression

Frontiers in Pharmacology, 2017
Nicotine and nicotinic acetylcholine receptors (nAChRs) are considered to be involved in lung cancer risk, onset and progression, but their precise physiological roles in these contexts remain unclear.
Hai-Ji Sun, Yan-Fei Jia, Xiao-Li Ma
doaj   +1 more source

Binding affinities of PMP-311 and PMP-072 for α7nAChR, α4β2 nAChR and α1β1 nAChR.

, 2015
Binding affinities of PMP-311 and PMP-072 for α7nAChR, α4β2 nAChR and α1β1 nAChR.
Gregory J. LaRosa (685996), Jessica Koepke (685991), Daniel Elbaum (685995), Paul P. Tak (23064), Frieda A. Koopman (613157), Roger Clark (685993), Margriet J. Vervoordeldonk (613162), Diana Lamppu (685994), Marjolein A. van Maanen (685989), Lisette Bevaart (685992), Roger L. Papke (685990)   +10 more
core   +1 more source

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

, 2020
Microglia controls the immune system response in the brain. Specifically, the activation and dysregulation of the NLRP3 inflammasome is responsible for the initiation of the inflammatory process through IL-1β and IL-18 release. In this work, we have
Céline Decouty-Pérez, López-Muñoz, Francisco, Muñoz-Montero, Alicia, Vanessa Gómez-Rangel, Palomino-Antolín, Alejandra, Gómez-Rangel, Vanessa, Egea, Javier, Francisco López-Muñoz, Luis Gandía, Paloma Narros-Fernández, Ramos Alonso, Eva, Lopez-Rodriguez, Ana Belen, Ana Belen Lopez-Rodriguez, Víctor Farré-Alins, Narros-Fernández, Paloma, Romero, Alejandro, Decouty-Pérez, Céline, Gandía, Luis, Alejandro Romero, Farré-Alins, Víctor, Javier Egea, Romero Martínez, Manuel Alejandro, Alicia Muñoz-Montero, González-Rodríguez, Águeda, Eva Ramos, Parada, Esther, Ramos, Eva, Alejandra Palomino-Antolín, Esther Parada, Águeda González-Rodríguez   +29 more
core   +1 more source

A G protein‐coupled α7 nicotinic receptor regulates signaling and TNF‐α release in microglia

FEBS Open Bio, 2017
Acetylcholine activation of α7 nicotinic acetylcholine receptors (α7 nAChRs) in microglia attenuates neuroinflammation and regulates TNF‐α release. We used lipopolysaccharide to model inflammation in the microglial cell line EOC20 and examined signaling ...
Justin R. King, Trudy C. Gillevet, Nadine Kabbani   +2 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source