Results 51 to 60 of about 10,119 (138)

Physicochemical, Functional, and Health‐Promoting Properties of Processed Nettle (Urtica Dioica) Leaves: A Review

Future Postharvest and Food, EarlyView.
Stinging nettle (Urtica dioica L.) leaves are a nutrient‐dense source of proteins, dietary fiber, chlorophylls, carotenoids, and phenolic compounds. Processing technologies enable the production of powders and extracts for incorporation into bakery, beverage, dairy, and nutraceutical products; however, challenges remain regarding sensory quality ...
Mary Nkongho Tanyitiku, Rakshya Pandit, Mihiri Vanniarachchy   +2 more
wiley   +1 more source

Sulfonium Ligands of the α7 nAChR

, 2021
The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor are ...
Nicole A. Horenstein, Roger L. Papke, Clare Stokes   +2 more
core   +1 more source

The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice

Biomedicines, 2023
Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR).
Young-Eun Kim, Jae-Hyun Lee, Eun-Ju Lee, Do Hoon Kim, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, Eun-Ju Chang, Yong-Gil Kim   +10 more
doaj   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets

Marine Drugs, 2019
Nicotinic acetylcholine receptors (nAChRs) are associated with various cancers, but the relation between nAChRs and cervical cancer remains unclear. Therefore, this study investigated the differential expression of nAChR subunits in human cervical cancer
Yiqiao Liu, Jiang Qian, Zhihua Sun, Dongting Zhangsun, Sulan Luo   +4 more
doaj   +1 more source

Integrating bioassays and transcriptomics to detect neonicotinoid resistance in Australian Bemisia tabaci MEAM1

Pest Management Science, EarlyView.
The Bemisia tabaci MEAM1 strain GR15‐1R shows partial resistance to neonicotinoids (bottom), which correlates with an increased expression of the P450 gene CYP6CM1 compared to the insecticide‐susceptible strain SU07‐1 (top). Abstract BACKGROUND Bemisia tabaci MEAM1 is a highly invasive and polyphagous pest species of agricultural and horticultural ...
Cao (Grace) Fang, Jacob Balzer, Michael Frese, Wee Tek Tay, Tom Walsh, Jamie Hopkinson   +5 more
wiley   +1 more source

Repeated administration of α7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases α7 nAChR levels in the brain

, 2010
The alpha7 nicotinic acetylcholine receptor (nAChR) is an important target for treatment of cognitive deficits in schizophrenia and Alzheimer's disease.
Thomsen, Morten S, Ditte Z. Christensen, Christensen, Ditte Z, Morten S. Thomsen, Henrik H. Hansen, Hansen, Henrik H, Jens D. Mikkelsen, Mikkelsen, Jens D   +7 more
core   +1 more source

Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model

Frontiers in Cellular Neuroscience, 2017
Triple-negative breast cancer (TNBC) subtype is associated with poor prognosis and a high risk of recurrence-related death in women. Despite the aggressiveness of TNBCs, targeted TNBC therapy is not yet available in the clinic. To overcome this challenge,
Li-Chi Huang, Ching-Ling Lin, Jia-Zheng Qiu, Chun-Yu Lin, Kai-Wen Hsu, Ka-Wai Tam, Ka-Wai Tam, Ka-Wai Tam, Jung-Yu Lee, Jinn-Moon Yang, Jinn-Moon Yang, Chia-Hwa Lee, Chia-Hwa Lee, Chia-Hwa Lee   +13 more
doaj   +1 more source

Rapid evolution and genetic basis of spinetoram resistance in Phthorimaea absoluta: evidence from six years of monitoring and laboratory selection

Pest Management Science, EarlyView.
Resistance to spinetoram in Phthorimaea absoluta is rapidly selected and functionally recessive at field‐relevant concentrations. Metabolic detoxification contributes partially, while cross‐resistance to spinosad and increased susceptibility to diamides and isoxazolines highlight practical options for resistance monitoring and insecticide rotation ...
Teófilo P. Langa, Vitor Quintela, Marcos de Oliveira, Herbert A. A. Siqueira   +3 more
wiley   +1 more source

Comparison of CM-II and vurtoxin effects on Cyt- and ACh-evoked currents in neurons containing predominantly nAChR-Ls-2 or nAChR-Ls-1.

, 2014
A - A neuron with low sensitivity to ImI against ACh-induced current (nAChR-Ls-2). CM-II at concentration of 500 nM heavily decreased the Cyt-elicited current but affected very slightly the response to ACh. B - Vurtoxin at concentration of 8 µM decreased
Sergey Yu. Filkin (676713), Vladislav G. Starkov (676710), Tatyana V. Andreeva (676712), Elena V. Gorbacheva (676714), Yuri N. Utkin (222421), Catherine A. Vulfius (676708), Alexey V. Osipov (676711), Igor E. Kasheverov (676709), Maxim E. Astashev (676715), Victor I. Tsetlin (676716)   +9 more
core   +1 more source