Results 71 to 80 of about 14,821 (156)

Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA

Marine Drugs, 2020
Nicotinic acetylcholine receptors (nAChRs) are membrane receptors and play a major role in tumorigenesis and cancer progression. Here, we have investigated the differential expression of nAChR subunits in human breast cancer cell lines and breast ...
Zhihua Sun, Manqi Zhangsun, Shuai Dong, Yiqiao Liu, Jiang Qian, Dongting Zhangsun, Sulan Luo   +6 more
doaj   +1 more source

Distinctive Roles for α7*- and α9*-Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Frontiers in Cellular Neuroscience, 2017
Previous studies have demonstrated immunosuppressive and anti-inflammatory effects of nicotine, including in the experimental autoimmune encephalomyelitis (EAE) model in mice of some forms of multiple sclerosis (MS).
Qiang Liu, Paul Whiteaker, Barbara J. Morley, Fu-Dong Shi, Ronald J. Lukas   +4 more
doaj   +1 more source

Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor.

PLoS ONE, 2013
BackgroundThe cholinergic anti-inflammatory pathway is an endogenous mechanism by which the autonomic nervous system attenuates macrophage activation via nicotinic acetylcholine receptors (nAChR).
Andrea Nemethova, Klaus Michel, Pedro J Gomez-Pinilla, Guy E Boeckxstaens, Michael Schemann   +4 more
doaj   +1 more source

6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor

Marine Drugs, 2015
6-Bromohypaphorine (6-BHP) has been isolated from the marine sponges Pachymatisma johnstoni, Aplysina sp., and the tunicate Aplidium conicum, but data on its biological activity were not available.
Igor E. Kasheverov, Irina V. Shelukhina, Denis S. Kudryavtsev, Tatyana N. Makarieva, Ekaterina N. Spirova, Alla G. Guzii, Valentin A. Stonik, Victor I. Tsetlin   +7 more
doaj   +1 more source

Does Abnormal Expression of Acetylcholine Receptors in Hirschsprung's Disease Induce Acetylcholine Esterase Positive Nerve Fibres?

Asian Journal of Surgery, 2007
Alpha bungarotoxin (α-BTX) is a neurotoxin isolated from the venom of Bungarus multicinctus that binds specifically to the β-subunits of nicotinic acetylcholine receptors (nAChR) on myotube membranes.
Junichi Kusafuka, Hiroyuki Kobayashi, Katsumi Miyahara, Geoffrey J. Lane, Noriyoshi Sueyoshi, Atsuyuki Yamataka   +5 more
doaj   +1 more source

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10

Frontiers in Cellular Neuroscience, 2017
Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of α7, α9 and/or α10 subunits ...
Anna Zakrzewicz, Katrin Richter, Alisa Agné, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Mike Althaus, Mike Althaus, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Veronika Grau, Veronika Grau   +17 more
doaj   +1 more source

Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig

Frontiers in Neuroimaging
The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen, Janus H. Magnussen, Anders Ettrup, Szabolcs Lehel, Dan Peters, Agnete Dyssegaard, Morten S. Thomsen, Morten S. Thomsen, Jens D. Mikkelsen, Jens D. Mikkelsen, Gitte M. Knudsen, Gitte M. Knudsen   +11 more
doaj   +1 more source

State-dependent binding of cholesterol and an anionic lipid to the muscle-type Torpedo nicotinic acetylcholine receptor

Communications Biology
The ability of the Torpedo nicotinic acetylcholine receptor (nAChR) to undergo agonist-induced conformational transitions requires the presence of cholesterol and/or anionic lipids.
Anna Ananchenko, Rui Yan Gao, François Dehez, John E. Baenziger   +3 more
doaj   +1 more source

Complement C3 inhibition restores myasthenia gravis AChR antibody-mediated muscle pathophysiology. [PDF]

EBioMedicine
Huang YF, Bhandage AK, Fichtner ML, Punga AR.   +3 more
europepmc   +1 more source

Motor neurons integrate cholinergic inputs through spatial organization of diverse nicotinic receptors. [PDF]

PNAS Nexus
Sitaula A, Kaur K, Mogharrabi A, Olsen L, Zarin A.   +4 more
europepmc   +1 more source