Results 71 to 80 of about 10,119 (138)

Tetrapeptide Ac-HAEE-NH2 Protects α4β2 nAChR from Inhibition by Aβ

, 2020
The cholinergic deficit in Alzheimer’s disease (AD) may arise from selective loss of cholinergic neurons caused by the binding of Aβ peptide to nicotinic acetylcholine receptors (nAChRs).
Victor I. Tsetlin, Anastasia A. Anashkina, Evgeny P. Barykin, Anna P. Tolstova, Irina V. Shelukhina, Yuri V. Mezentsev, Aleksandra I. Garifulina, Sergey A. Kozin, Alexei A. Adzhubei, Alexander A. Makarov   +9 more
core   +1 more source

Natural Compounds Interacting with Nicotinic Acetylcholine Receptors: From Low-Molecular Weight Ones to Peptides and Proteins

Toxins, 2015
Nicotinic acetylcholine receptors (nAChRs) fulfill a variety of functions making identification and analysis of nAChR subtypes a challenging task. Traditional instruments for nAChR research are d-tubocurarine, snake venom protein α-bungarotoxin (α-Bgt ...
Denis Kudryavtsev, Irina Shelukhina, Catherine Vulfius, Tatyana Makarieva, Valentin Stonik, Maxim Zhmak, Igor Ivanov, Igor Kasheverov, Yuri Utkin, Victor Tsetlin   +9 more
doaj   +1 more source

Varenicline for cannabis use disorder: A randomized controlled trial

Addiction, EarlyView.
Abstract Background and aims Although cannabis use is widespread and prevalence of cannabis use disorder (CUD) is increasing, limited advancements have been made in CUD medication development. The objective of this study was to test the efficacy of varenicline with medical management for reducing cannabis use in treatment‐seeking individuals with CUD ...
Aimee L. McRae‐Clark, Kevin M. Gray, Nathaniel L. Baker, Brian J. Sherman, Bryan Tolliver, Jessica Burt, Alonzo Steplight, Elizabeth Chapman, Amanda Wagner   +8 more
wiley   +1 more source

Identification of N-terminal Extracellular Domain Determinants in Nicotinic Acetylcholine Receptor (nAChR) α6 Subunits That Influence Effects of Wild-type or Mutant β3 Subunits on Function of α6β2*- or α6β4*-nAChR [PDF]

, 2011
Despite the apparent function of naturally expressed mammalian α6*-nicotinic acetylcholine receptors (α6*-nAChR; where*indicates the known or possible presence of additional subunits), their functional and heterologous expression has been difficult ...
Dash, Bhagirathi, Bhagirathi Dash, Chang, Yongchang, Minoti Bhakta, Yongchang Chang, Bhakta, Minoti, Lukas, Ronald J., Ronald J. Lukas   +7 more
core   +1 more source

DataSheet_1_Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier.pdf

, 2021
Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) is critical for the pathogenesis of Escherichia coli (E. coli) K1 meningitis, a severe central nervous system infection of the neonates. However, little is known about how E.
Liqun Liu (316613), Yu Wan (172089), Jie Gao (10266), Feng Chi (170688), Peilin Zhen (11562460), Hong Cao (122228), Beiguo Long (11562457), Li Li (14993), Tiesong Zhang (9539723), Lei Wang (6656), Tongtong Hu (6455477), Xiaolong He (3765574), Zelong Gong (6455480), Sheng-He Huang (121266)   +13 more
core   +1 more source

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Labeling of β2 and α7 nAChR subunits in tissue resident macrophages in the stomach and ileum.

, 2013
Tissue resident macrophages were immunohistochemically labeled for F4/80 (red). A; Resident macrophages in stomach muscularis of a wild-type mouse were β2 nAChR-immunoreactive (green).
Pedro J. Gomez-Pinilla (478993), Michael Schemann (154153), Klaus Michel (478992), Andrea Nemethova (478991), Guy E. Boeckxstaens (421150)   +4 more
core   +1 more source

Low-dose nicotine activates EGFR signaling via alpha5-nAChR and promotes lung adenocarcinoma progression

, 2020
[[abstract]]Nicotine in tobacco smoke is considered carcinogenic in several malignancies including lung cancer. The high incidence of lung adenocarcinoma (LAC) in non-smokers, however, remains unexplained.
Wang, ML;Hsu, YF;Liu, CH;Kuo, YL;Chen, YC;Yeh, YC;Ho, HL;Wu, YC;Chou, TY;Wu, CW
core   +2 more sources

Structural basis for allosteric agonism of human α7 nicotinic acetylcholine receptors

Cell Discovery
The α7 nicotinic acetylcholine receptor (nAChR), a pentameric ligand-gated ion channel, plays important roles in cognition, neuroprotection, and anti-inflammation.
Sanling Liu, Yining Zheng, Haopeng Chen, Xin Li, Qipeng Yan, Wenjun Mu, Yaning Fu, Huan Chen, Hongwei Hou, Lei Liu, Changlin Tian   +10 more
doaj   +1 more source

Cross‐sectional and longitudinal associations of cannabis use with cognitive functioning in individuals with a cannabis use disorder: The moderating role of nicotine

Addiction, EarlyView.
Abstract Background and Aims Cannabis is among the most widely used psychoactive substances globally and is often consumed alongside tobacco. Cannabis use has been associated with impairments in attention, learning, and memory, whereas nicotine can acutely enhance, but chronically impair, certain cognitive functions.
Emese Kroon, Nora de Bode, Karis Colyer‐Patel, Jia Hua Hsieh, Francesca Filbey, Janna Cousijn   +5 more
wiley   +1 more source