Results 31 to 40 of about 76,340 (268)
Journal of Cellular and Molecular Medicine, 2020 Recent studies have showed that α5 nicotinic acetylcholine receptor (α5‐nAChR) is closely associated with nicotine‐related lung cancer. Our previous studies also demonstrated that α5‐nAChR mediates nicotine‐induced lung carcinogenesis.
Xiaowei Chen +5 more
semanticscholar +1 more source
Interactions of Globular and Ribbon [γ4E]GID with α4β2 Neuronal Nicotinic Acetylcholine Receptor
Marine Drugs, 2021 The α4β2 nAChR is implicated in a range of diseases and disorders including nicotine addiction, epilepsy and Parkinson’s and Alzheimer’s diseases. Designing α4β2 nAChR selective inhibitors could help define the role of the α4β2 nAChR in such disease ...
Xiaosa Wu, David J. Craik, Quentin Kaas
doaj +1 more source
Journal of Cellular and Molecular Medicine, 2020 Periodontitis is the leading cause of adult tooth loss, and those who smoke are at an increased risk of developing periodontitis. α7 nicotinic acetylcholine receptor (α7 nAChR) is proposed to mediate the potential synergistic effect of nicotine and ...
Zhifei Zhou +6 more
semanticscholar +1 more source
Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs [PDF]
, 2009 Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic synapse development.
Elgoyhen, Ana Belen +3 more
core +1 more source
Acetylcholine receptor subunit expression in Huntington's disease mouse muscle
Biochemistry and Biophysics Reports, 2021 Huntington's disease (HD) causes neurological impairments, as well as muscle dysfunction, including smaller neuromuscular junctions (NMJs). This study assessed the expression levels of the subunits of the nicotinic acetylcholine receptor (nAChR) in ...
Briana Simpson +3 more
doaj +1 more source
Tetrapeptide Ac-HAEE-NH2 Protects α4β2 nAChR from Inhibition by Aβ
International Journal of Molecular Sciences, 2020 The cholinergic deficit in Alzheimer’s disease (AD) may arise from selective loss of cholinergic neurons caused by the binding of Aβ peptide to nicotinic acetylcholine receptors (nAChRs).
E. Barykin +9 more
semanticscholar +1 more source
Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]
, 2011 The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors.
Andrew L. Varnell +3 more
core +3 more sources
Molecules, 2019 Nicotinic acetylcholine receptors (nAChRs), serotonin transporters (SERT) and dopamine transporters (DAT) represent targets for the development of novel nicotinic derivatives acting as multiligands associated with different health conditions, such as ...
Juan Pablo González-Gutiérrez +11 more
doaj +1 more source
Data in Brief, 2020 For a long time, traditional purification and extraction methods for the native Torpedo californica nicotinic acetylcholine receptor in lipid-like detergent complex (nAChR-DC) have compromised its purity, functionality and X-ray structural studies ...
Rafael Maldonado-Hernández +2 more
doaj +1 more source
Marine Drugs, 2020 Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom.
Xiaodan Li +6 more
doaj +1 more source