Results 51 to 60 of about 63,766 (174)

Nicotine promotes M2 macrophage polarization through α5-nAChR/SOX2/CSF-1 axis in lung adenocarcinoma

Cancer Immunology, Immunotherapy
α5-nicotinic acetylcholine receptor (α5-nAChR) plays a vital part in lung adenocarcinoma (LUAD). However, it is not comprehensively understood that how the α5-nAChR affects LUAD.
Guiyu Kang, Hui Song, Lei Bo, Qi Liu, Qiang Li, Jingtan Li, Pan Pan, Jingting Wang, Yanfei Jia, Haiji Sun, Xiaoli Ma   +10 more
doaj   +1 more source

Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells. [PDF]

PLoS ONE, 2016
Gastric cancer incidence demonstrates a strong etiologic association with smoking. Nicotine, the major component in tobacco, is a survival agonist that inhibits apoptosis induced by certain chemotherapeutic agents, but the precise mechanisms involved ...
Yanfei Jia, Haiji Sun, Hongqiao Wu, Huilin Zhang, Xiuping Zhang, Dongjie Xiao, Xiaoli Ma, Yunshan Wang   +7 more
doaj   +1 more source

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

α5-nAChR/NETO2 contributed to chronic stress-promoted lung adenocarcinoma progression

Cancer Cell International
Background α5-nicotinic acetylcholine receptor (α5‐nAChR) participates in chronic stress-promoted lung adenocarcinoma (LUAD) progression. Neuropilin and tolloid-like 2 (NETO2) contributes to fear expression and extinction, which is related to ...
Jingting Wang, Jiaying Cai, Zengping Wang, Shuran Yang, Jing Wang, Yanfei Jia, Haiji Sun, Xiaoli Ma   +7 more
doaj   +1 more source

Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets

Marine Drugs, 2019
Nicotinic acetylcholine receptors (nAChRs) are associated with various cancers, but the relation between nAChRs and cervical cancer remains unclear. Therefore, this study investigated the differential expression of nAChR subunits in human cervical cancer
Yiqiao Liu, Jiang Qian, Zhihua Sun, Dongting Zhangsun, Sulan Luo   +4 more
doaj   +1 more source

Nikotinski acetilholinski receptor kot farmakološka tarča pri pljučnem raku

Acta Biologica Slovenica, 2022
Rak pljuč je zelo razširjena oblika raka z nizko stopnjo preživetja. Kajenje tobaka predstavlja glavni dejavnik tveganja za razvoj raka pljuč, saj v tobačnem dimu najdemo veliko rakotvornih snovi.
Veno Kononenko, Tadeja Bele, Sara Novak, Igor Križaj, Damjana Drobne, Tom Turk   +5 more
doaj   +1 more source

Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse. [PDF]

, 2019
Homomeric α7 nicotinic acetylcholine receptors (nAChRs) are abundantly expressed in the central and peripheral nervous system (CNS and PNS, respectively), and spinal cord.
Broide, Ron S, Chen, Yling, Leslie, Frances M, Winzer-Serhan, Ursula H   +3 more
core   +1 more source

On some normability conditions [PDF]

, 2005
Various normability conditions of locally convex spaces (including Vogt interpolation classes DN and as well as quasi- and asymptotic normability) are investigated.
Aytuna, Aytuna, Bierstedt, Bierstedt, Bonet, Bonet, Bonet, Bonet, Dubinsky, Goncharov, Grothendieck, Grothendieck, Jarchow, Kocatepe, Köthe, Köthe, Meise, Meise, Mityagin, Mityagin, Mityagin, Terzioğlu, Terzioğlu, Tidten, Valdivia, Vogt, Vogt, Vogt, Vogt, Zahariuta, Zahariuta, Zahariuta, Zahariuta, Zahariuta, Önal, Önal   +35 more
core   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

Placental‐Derived Connective Tissue Matrix Mediates Murine Recurrent Laryngeal Nerve Regeneration

The Laryngoscope, EarlyView.
Placentally derived connective tissue matrix (pd‐CTM) innately contains various neurotrophic, angiogenic, anti‐inflammatory, and tissue remodeling cytokines. In this mouse model of unilateral vocal fold paralysis, we investigate its effects on recurrent laryngeal nerve (RLN) regeneration and reinnervation of the right thyroarytenoid (TA) muscle after ...
Sunjay Anekal, Ananya Tadikonda, Gabriel Sobczak, Lena W. Chen, Aditya Bhatt, Troy Wesson, Patrick R. Finnegan, Stacey Halum   +7 more
wiley   +1 more source