Results 101 to 110 of about 15,320 (194)
Ganglionic nAChRs and high-affinity nicotinic binding sites are not equivalent
, 1986 High-affinity (Kd ⋍ 10 nM) binding sites for nicotine and acetylcholine (ACh) have recently been identified in vertebrate brain. It has been suggested that these sites are desensitized ganglionic (C6) nicotinic acetylcholine receptors (nAChRs).
Kemp, George +3 more
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ROCK regulates N-cadherin-mediate α3β4-myc nAChRs distribution on the cell surface.
, 2013 CHO cells expressing N-cadherin and α3β4-myc nAChRs were treated with DMSO (10 µl/ml) or with the indicated drugs: LAT-A 10 µM, CTCH-D 2 µM, RhoA Inh 1 µg/ml, and the ROCK inhibitor Y27632 10 µM. A) Effect of pharmacological treatments on α3β4-myc nAChRs
Juan L. Brusés (406197)
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, 2015 The α9α10-nicotinic acetylcholine receptor (nAChR) has been implicated in pain and has been proposed to be a novel target for analgesics. However, the evidence to support the involvement of the α9α10-nAChR in pain is conflicted.
Sarasa Mohammadi +3 more
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Nicotine receptor subunits (nAChRs) are expressed in podocytes.
, 2016 A. Total RNAs were prepared from differentiated human podocytes, and were used for RT-PCR to detect the expression of nAChR subunits. GAPDH was used as internal control. B.
Pravin C. Singhal (335757) +6 more
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, 2019 BackgroundNicotinic and muscarinic acetylcholine receptors likely evolved in the cnidarian–bilaterian common ancestor. Both receptor families are best known for their role at chemical synapses in bilaterian animals, but they also have described roles ...
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Frontiers in Molecular NeuroscienceThe neurotransmitter acetylcholine has since long been implicated in reward learning and drug addiction. However, the role of specific cholinergic receptor subtypes on different neuronal populations remain elusive.
Michael Fritz +12 more
doaj +1 more source
Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs
, 2015 In 1929, Dale and Dudley described the first reported natural occurrence of acetylcholine (ACh) in an animal’s body. They identified this ACh in the spleens of horses and oxen, which we now know suggests possible involvement of ACh in the regulation of ...
Kawashima, Koichiro +4 more
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L-EGF is sufficient to induce the functional expression of excitatory nAChRs.
, 2014 (a) Single LPeD1 neurons were cultured in CM and impaled with intracellular electrodes. Exogenous application of ACh (10−6 M) triggered an excitatory response in the postsynaptic neuron, LPeD1 (n = 33). (ai) The EGFR inhibitor PD153035 (200 nM) prevented
Frank Visser (649731) +4 more
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The expression and function of nAChRs in human T cells
Nicotinic acetylcholine receptors (nAChRs) are known to modulate immune responses, but their specific role in human T cells remains poorly understood. This thesis project aimed to investigate the expression, regulation, and functional roles of nAChRs in ...
Laforest, Bailey
core
Unprocessed data. All the relevant information regarding the data can be found in the paper: Astrocytic α4-containing nAChRs Signaling in the Hippocampus Governs the Formation of Temporal Association Memory.
Ma, I
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