Results 81 to 90 of about 15,320 (194)

Inhalt: Nachr. Chem. [PDF]

Nachrichten aus der Chemie, 2022
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Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward [PDF]

, 2016
Upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nAChRs) is implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to upregulate β2* nAChRs more than nonmenthol cigarette smokers.
Kim, Charlene H., Henley, Beverley M., Lester, Henry A., Henderson, Brandon J., Nichols, Weston A., Moaddel, Ruin, Xiao, Cheng, Wall, Teagan R.   +7 more
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N-cadherin homotypic binding regulates the cell surface localization of α3β4-myc nAChRs.

, 2013
A) CHO cells transfected with N-cadherin-EGFP and cell surface labeled with anti-N-cadherin antibodies (NCD2) show expression of N-cadherin at the cell membrane (arrowheads) and N-cadherin accumulation at the intercellular junction (arrows).
Juan L. Brusés (406197)
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nAChRs gene expression and neuroinfammation inAPPswe/PS1dE9 transgenic mouse

, 2022
An evaluation of the APPswe/PS1dE9 transgenic AD mouse, presenting with the toxic Aβ1-42 deposition found in human AD, allowed us to characterize time-dependent changes in inflammatory and cholinergic markers present in AD.
Di Nicola, Marta, Greig, Nigel H., Reale, Marcella, Costantini, E., Salvador Cabos, Nieves, Marchioni, Michele, D'Angelo, Chiara   +6 more
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The α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area.

PLoS ONE, 2013
Human genetic association studies have shown gene variants in the α5 subunit of the neuronal nicotinic receptor (nAChR) influence both ethanol and nicotine dependence.
Susmita Chatterjee, Nathan Santos, Joan Holgate, Carolina L Haass-Koffler, F Woodward Hopf, Viktor Kharazia, Henry Lester, Antonello Bonci, Selena E Bartlett   +8 more
doaj   +1 more source

Effects of Ivermectin as an Allosteric Modulator of nAChRs on Dopamine Release

, 2022
Dopamine (DA) terminals are regulated by acetylcholine activity on nicotinic receptors (nAChRs). Nicotine reduces DA release from low frequency stimulation, but enhances release at higher frequencies.
Robinson, J. Kayden, Bishop, Samantha, Foote, Sarah E., Graul, Benjamin E., Steimle, Emma, Hafen, Caylor, Yorgason, Jordan, Wadsworth, Hillary, Barlow, Joshua   +8 more
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Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain

Marine Drugs
α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized,
Hongyu Shan, Nan Wang, Xinyu Gao, Zihan Wang, Jinpeng Yu, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo   +7 more
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β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward

, 2019
International audienceEvidence shows that the neurotransmitter dopamine mediates the rewarding effects of nicotine and other drugs of abuse, while nondopaminergic neural substrates mediate the negative motivational effects.
van Der Kooy, Derek, Besson, Morgane, Maskos, Uwe, Maal-Bared, Geith, Pons, Stéphanie, Grieder, Taryn   +5 more
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Role of α6 nAChRs in Ethanol Modulation of VTA Neurons

, 2014
The prevailing view is that enhancement of dopamine (DA) transmission in the mesolimbic system leads to the rewarding properties of alcohol and nicotine (NIC).
Shin, Samuel Injae
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α3β4-myc nAChRs at to the apical cell surface do not colocalize with microtubules.

, 2013
Deconvoluted confocal images at low and high magnification of the apical surface of α3β4-myc nAChRs expressing Caco-2 cells immunolabeled with anti-acetylated α-tubulin (A) and β-tubulin (B) antibodies show no colocalization of α3β4-myc nAChRs with ...
Juan L. Brusés (406197)
core   +1 more source