Results 71 to 80 of about 15,320 (194)

Personalizing smoking cessation pharmacotherapy using neuroaffective reactivity profiles: A randomized controlled trial

Addiction, Volume 121, Issue 7, Page 1888-1898, July 2026.
Abstract Background and aims By assessing neuroaffective response to motivationally relevant cues before a quit attempt, we have shown that smokers who attribute greater incentive salience to cigarette‐related cues than non‐cigarette‐related rewards (Sign‐trackers, ST) benefit more from varenicline compared with smokers with the opposite neuroaffective
Francesco Versace, Charles E. Green, Yong Cui, Jason D. Robinson, Menton M. Deweese, Jennifer A. Minnix, George Kypriotakis, Seokhun Kim, Maher Karam‐Hage, Paul M. Cinciripini   +9 more
wiley   +1 more source

Alpha-2 nicotinic acetylcholine receptors regulate spectral integration in auditory cortex

Frontiers in Neural Circuits
IntroductionIn primary auditory cortex (A1), nicotinic acetylcholine receptors (nAChRs) containing α2 subunits are expressed in layer 5 Martinotti cells (MCs)—inhibitory interneurons that send a main axon to superficial layers to inhibit distal apical ...
Irakli Intskirveli, Susan Gil, Ronit Lazar, Raju Metherate   +3 more
doaj   +1 more source

Epibatidine Induces Long-Term Potentiation (LTP) via Activation of α4β2 Nicotinic Acetylcholine Receptors (nAChRs) In Vivo in the Intact Mouse Dentate Gyrus: Both α7 and α4β2 nAChRs Essential to Nicotinic LTP

Journal of Pharmacological Sciences, 2003
: Activation of nicotinic acetylcholine receptors (nAChRs) induces nocotinic long-term potentiation (LTPn) in vivo in the mouse dentate gyrus. We have found that α4β2 nAChRs activated by epibatidine induce LTPn, the full size of which requires the ...
Shogo Matsuyama, Akira Matsumoto
doaj   +1 more source

Nicotine Exposure During Pregnancy and Postnatal Cognitive Outcomes: A Systematic Review and Meta‐Analysis

Acta Paediatrica, Volume 115, Issue 7, Page 1413-1428, July 2026.
ABSTRACT Aim Nicotine exposure during pregnancy interferes with critical periods of foetal brain development, disrupting the timing and functioning of neurodevelopment. This systematic review and meta‐analysis aims to evaluate the effect of prenatal nicotine exposure on postnatal cognitive outcomes.
Deimantė Baguckaitė, Judith Covey, Nadja Reissland   +2 more
wiley   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

ACh concentration-response relations for α5α4β2 and α5α4β2V287L nAChRs.

, 2016
The α5α4β2 and α5α4β2V287L receptors were expressed in Xenopus oocytes using a large excess of α5 mRNA (α5:α4:β2 mRNA injection ratio of 10:1:1 w/w/w) to ensure that α5-containing (α5*) nAChRs were the predominantly expressed subtype. a-b.
Weston A. Nichols (2851631), Chris Richards (2851634), Christopher B. Marotta (2851643), Brandon J. Henderson (205764), Henry A. Lester (201363), Dennis A. Dougherty (1319310), Bruce N. Cohen (2851637), Caroline Y. Yu (2851640)   +7 more
core   +1 more source

Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHβE suggests a unique mode of antagonism.

PLoS ONE, 2012
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that belong to the Cys-loop receptor superfamily. These receptors are allosteric proteins that exist in different conformational states, including resting (closed ...
Azadeh Shahsavar, Jette S Kastrup, Elsebet Ø Nielsen, Jesper L Kristensen, Michael Gajhede, Thomas Balle   +5 more
doaj   +1 more source

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells‐Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
In this study, human astrocytes were obtained from induced pluripotent stem cells (iPSCs) of Parkinson's disease (PD) patients carrying the G2019S LRRK2 mutation, the most common genetic cause of PD. These astrocytes display a reactive and inflammatory profile, with increased GFAP levels, elevated cytokine release, and reduced support for dopaminergic ...
Veronica Mutti, Federica Bono, Zaira Tomasoni, Dounia Fadel, Chiara Gnutti, Giulia Sbrini, Carolina Gaudenzi, Valentina Salvi, Daniela Bosisio, Isabella Russo, Silvia Bolognin, Jens C. Schwamborn, Cristina Missale, Chiara Fiorentini   +13 more
wiley   +1 more source

Molecular and pharmacological characterization of nicotinic acetylcholinereceptors (nAChRs) in insects

, 2014
Nicotinic acetylcholine receptors (nAChRs) areinvolved in several functions in insects and are themain target of neonicotinoid insecticides. Wedemonstrated that neonicotinoids, such asimidacloprid, thiamethoxam and clothianidin displaydifferent toxicity ...
Taillebois, Emiliane
core   +1 more source

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source